Rate of Adaptation in Large Sexual Populations

Adaptation often involves the acquisition of a large number of genomic changes which arise as mutations in single individuals. In asexual populations, combinations of mutations can fix only when they arise in the same lineage, but for populations in which genetic information is exchanged, beneficial mutations can arise in different individuals and be combined later. In large populations, when the product of the population size N and the total beneficial mutation rate U_b is large, many new beneficial alleles can be segregating in the population simultaneously. We calculate the rate of adaptation, v, in several models of such sexual populations and show that v is linear in NU_b only in sufficiently small populations. In large populations, v increases much more slowly as log NU_b. The prefactor of this logarithm, however, increases as the square of the recombination rate. This acceleration of adaptation by recombination implies a strong evolutionary advantage of sex

Is the GSI anomaly due to neutrino oscillations? - A real time perspective -

We study a model for the "GSI anomaly" in which we obtain the time evolution of the population of parent and daughter particles directly in real time, considering explicitly the quantum entanglement between the daughter particle and neutrino mass eigenstates in the two-body decay. We confirm that the decay rate of the parent particle and the growth rate of the daughter particle do \emph{not} feature a time modulation from interference of neutrino mass eigenstates. The lack of interference is a consequence of the orthogonality of the mass eigenstates. This result also follows from the density matrix obtained by tracing out the unobserved neutrino states. We confirm this result by providing a complementary explanation based on Cutkosky rules applied to the Feynman diagram that describes the self-energy of the parent particle.Comment: 11 page

A Simple Modularity Measure for Search Spaces based on Information Theory

Within the context of Artificial Life the question about the role of modularity has turned out to be crucial, especially with regard to the problem of evolvability. In order to be able to observe the development of modular structure, appropriate modularity measures are important. We introduce a continuous measure based on information theory which can characterize the coupling among subsystems in a search problem. In order to illustrate the concepts developed, they are applied to a very simple and intuitive set of combinatorial problems similar to scenarios used in the seminal work by Simon (1969). It is shown that this measure is closely related to the classification of search problems in terms of Separability, Non-Decomposability and Modular Interdependency as introduced in (Watson and Pollack, 2005)

Viscoelastic properties of human and bovine articular cartilage : a comparison of frequency-dependent trends

Acknowledgments The authors would like to thank Spencer C. Barnes and Hamid Sadeghi for assistance during experimentation. We would also like to thank patients donating tissue and the surgeons collecting these. Funding The equipment used in this study was funded by Arthritis Research UK (Grant number H0671). We are grateful to Arthritis Research UK for the award of a PhD studentship to Anna A. Cederlund (Grant number 19971). Arthritis Research UK had no role in the design of the study and collection, analysis and interpretation of data and in writing the manuscript.Peer reviewedPublisher PD

Pion Photoproduction Amplitude Relations in the 1/N_c Expansion

We derive expressions for pion photoproduction amplitudes in the 1/N_c expansion of QCD, and obtain linear relations directly from this expansion that relate electromagnetic multipole amplitudes at all energies. The leading-order relations in 1/N_c compare favorably with available data, while the next-to-leading order relations seem to provide only a small improvement. However, when resonance parameters are compared directly, the agreement at O(1/N_c) or O(1/N_c^2) is impressive.Comment: 19 pages, ReVTeX, 50 eps files combine into 5 compound figure

Modal Analysis of a Two-Parachute System

The Orion capsule is designed to land under a nominal configuration of three main parachutes; however, the system is required to be fault tolerant and land successfully if one of the main parachutes fails to open. The Capsule Parachute Assembly System (CPAS) Team performed a series of drop tests in order to characterize the performance of the system with two main parachutes. During the series of drop tests, several distinct dynamical modes were observed. The most consequential of these is the pendulum mode. Three other modes are benign: flyout (scissors), maypole, and breathing. The actual multi-body system is nonlinear, flexible, and possesses significant cross-coupling. Rather than perform analysis of this highly complex system directly, we conduct analysis of each dynamical mode observed during flight, based on first principles. This approach is analogous to traditional aircraft flight dynamics analysis in which the full nonlinear behavior of the airframe is decomposed into longitudinal dynamics (phugoid and short-period modes) and lateral dynamics (spiral, roll-subsidence, and dutch-roll modes). This analysis is intended to supplement multi-body nonlinear simulations in order to provide further insight into the system