Morphological Integration of Soft-Tissue Facial Morphology in Down Syndrome and Siblings

Down syndrome (DS), resulting from trisomy of chromosome 21, is the most common live-born human aneuploidy. The phenotypic expression of trisomy 21 produces variable, though characteristic, facial morphology. Although certain facial features have been documented quantitatively and qualitatively as characteristic of DS (e.g., epicanthic folds, macroglossia, and hypertelorism), all of these traits occur in other craniofacial conditions with an underlying genetic cause. We hypothesize that the typical DS face is integrated differently than the face of non-DS siblings, and that the pattern of morphological integration unique to individuals with DS will yield information about underlying developmental associations between facial regions. We statistically compared morphological integration patterns of immature DS faces (N = 53) with those of non-DS siblings (N = 54), aged 6–12 years using 31 distances estimated from 3D coordinate data representing 17 anthropometric landmarks recorded on 3D digital photographic images. Facial features are affected differentially in DS, as evidenced by statistically significant differences in integration both within and between facial regions. Our results suggest a differential affect of trisomy on facial prominences during craniofacial development

Off-line-locked laser diode species monitor system

An off-line-locked laser diode species monitor system includes: reference means for including at least one known species having a first absorption wavelength; a laser source for irradiating the reference means and at least one sample species having a second absorption wavelength differing from the first absorption wavelength by a predetermined amount; means for locking the wavelength of the laser source to the first wavelength of the at least one known species in the reference means; a controller for defeating the means for locking and for displacing the laser source wavelength from said first absorption wavelength by said predetermined amount to the second absorption wavelength; and a sample detector device for determining laser radiation absorption at the second wavelength transmitted through the sample to detect the presence of the at least one sample species

Mind-Body Skills Groups for Adolescents with Depression in Primary Care: A Pilot Study

Objective: To determine acceptability and preliminary effectiveness of Mind-Body Skills Groups (MBSGs) as a treatment for depressed adolescents in primary care. Methods: A single arm clinical trial was conducted. A 10-week MBSG program was implemented in primary care. Participants completed self-report measures at baseline, post-intervention, and 3-months following the MBSGs. Measures included the Children’s Depression Inventory-2, Suicidal Ideation Questionnaire, Mindful Attention Awareness Scale, Self-Efficacy for Depressed Adolescents, rumination subscale of the Children’s Response Style Questionnaire, and a short acceptability questionnaire. Results: Participants included 43 adolescents. The total depression scores significantly improved following the MBSG intervention and continued to improve significantly from post-treatment to follow-up. Mindfulness, self-efficacy, rumination, and suicidal ideation all had significant improvement following the intervention. Acceptability of the program was strong, and attendance was excellent. Discussion: Preliminary evidence suggests that MBSGs are an acceptable treatment for primary care settings and lead to improved depression symptoms in adolescents.Sandra Eskenazi Mental Health Center and the Herbert Simon Family Foundation (070241-00002B

A critical evaluation of the Down syndrome diagnosis for LB1, type specimen of Homo floresiensis

The Liang Bua hominins from Flores, Indonesia, have been the subject of intense scrutiny and debate since their initial description and classification in 2004. These remains have been assigned to a new species, Homo floresiensis, with the partial skeleton LB1 as the type specimen. The Liang Bua hominins are notable for their short stature, small endocranial volume, and many features that appear phylogenetically primitive relative to modern humans, despite their late Pleistocene age. Recently, some workers suggested that the remains represent members of a small-bodied island population of modern Austro-Melanesian humans, with LB1 exhibiting clinical signs of Down syndrome. Many classic Down syndrome signs are soft tissue features that could not be assessed in skeletal remains. Moreover, a definitive diagnosis of Down syndrome can only be made by genetic analysis as the phenotypes associated with Down syndrome are variable. Most features that contribute to the Down syndrome phenotype are not restricted to Down syndrome but are seen in other chromosomal disorders and in the general population. Nevertheless, we re-evaluated the presence of those phenotypic features used to support this classification by comparing LB1 to samples of modern humans diagnosed with Down syndrome and euploid modern humans using comparative morphometric analyses. We present new data regarding neurocranial, brain, and symphyseal shape in Down syndrome, additional estimates of stature for LB1, and analyses of inter- and intralimb proportions. The presence of cranial sinuses is addressed using CT images of LB1. We found minimal congruence between the LB1 phenotype and clinical descriptions of Down syndrome. We present important differences between the phenotypes of LB1 and individuals with Down syndrome, and quantitative data that characterize LB1 as an outlier compared with Down syndrome and non-Down syndrome groups. Homo floresiensis remains a phenotypically unique, valid species with its roots in Plio-Pleistocene Homo taxa

Down syndrome-recent progress and future prospects

Down syndrome (DS) is caused by trisomy of chromosome 21 (Hsa21) and is associated with a number of deleterious phenotypes, including learning disability, heart defects, early-onset Alzheimer's disease and childhood leukaemia. Individuals with DS are affected by these phenotypes to a variable extent; understanding the cause of this variation is a key challenge. Here, we review recent research progress in DS, both in patients and relevant animal models. In particular, we highlight exciting advances in therapy to improve cognitive function in people with DS and the significant developments in understanding the gene content of Hsa21. Moreover, we discuss future research directions in light of new technologies. In particular, the use of chromosome engineering to generate new trisomic mouse models and large-scale studies of genotype-phenotype relationships in patients are likely to significantly contribute to the future understanding of DS

Contributions of Speaking, Listening, and Semantic Depth to Word Learning in Typical 3- and 4-Year-Olds

Purpose: This study examined learning via perception, learning via production, and semantic depth as contributors to word learning in preschool-aged children. There is broad evidence that semantic depth is an important contributor to word learning, especially when semantic cues are repeated and spaced out over time. Perceptual learning and production learning each support word learning sometimes, but not in all cases. The purpose of this study was to examine all three learning mechanisms within a single experimental paradigm. Method: Thirty-six typically developing preschool children completed the experiment. They were familiarized with 16 novel words that were contextualized as alien names. These aliens came in four sets, each set comprising one base alien and three modified aliens marked by suffixes. Children completed four familiarizations: two in which they simply listened to the alien names (perceptual learning) and two where they repeated the alien names (production learning). Those conditions were crossed with a semantic depth manipulation (aliens with and without verbal semantic cues). Following each familiarization, referent identification and confrontation naming tasks were completed to assess learning. Results: Children were able to identify more alien referents following familiarizations with semantic depth. There were no significant effects of either perceptual learning or production learning. Conclusions: This study confirms and expands on the benefits of semantic depth, but the results are unclear about the relative importance of perception and production to word learning. Nevertheless, the study suggests benefits to simultaneously studying multiple factors related to word learning

Electromyographic (EMG) Activity of the Gluteus Medius during Various Hip Exercises

Background and Purpose. The purpose of the study was to record and analyze muscle recruitment patterns of the gluteus medius and gluteus maximus muscles when performing a side lying abduction exercise requiring consistent force to roll a ball up and down the wall using the dominant lower extremity. Comparisons were made between the use of either a small, medium or large ball. The subjects performed a standing abduction exercises with theraband around both ankles as well. Case Description. Fifteen subjects were recruited from the University of North Dakota Department of Physical Therapy to perform the four different types of exercises. All subjects met the inclusion criteria which required them to be healthy adults over the age of 18. The exclusion criteria included hip or low back pain in the past three months and allergic reactions to adhesives. Intervention. Exercise order was randomly assigned and all subjects completed each of the exercises. Three repetitions of each exercise were completed, while EMG equipment was used to measure the amount of muscle activity generated in the gluteus medius and maximus muscles in the dominant leg. Outcomes. There were no statistically significant differences found between the exercises. There were some trends observed in the data which behoove the need for further research to be done. Discussion. There are multiple factors to take into consideration as to how this study could be changed or expanded upon to yield significant findings. The fact remains that further and more extensive research is needed

An Evaluation, Using Behavioral Objectives, of Test 4, "Ability to Do Quantitative Thinking," from The Iowa Tests of Educational Development

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