Entropy, Ergodicity and Stem Cell Multipotency

Populations of mammalian stem cells commonly exhibit considerable cell-cell variability. However, the functional role of this diversity is unclear. Here, we analyze expression fluctuations of the stem cell surface marker Sca1 in mouse hematopoietic progenitor cells using a simple stochastic model and find that the observed dynamics naturally lie close to a critical state, thereby producing a diverse population that is able to respond rapidly to environmental changes. We propose an information-theoretic interpretation of these results that views cellular multipotency as an instance of maximum entropy statistical inference.Comment: 6 pages, 3 figure

Chromatic transit light curves of disintegrating rocky planets

Context. Kepler observations have revealed a class of short period exoplanets, of which Kepler-1520 b is the prototype, which have comet-like dust tails thought to be the result of small, rocky planets losing mass. The shape and chromaticity of the transits constrain the properties of the dust particles originating from the planet's surface, offering a unique opportunity to probe the composition and geophysics of rocky exoplanets. Aims. We aim to approximate the average Kepler long-cadence light curve of Kepler-1520 b and investigate how the optical thickness and transit cross-section of a general dust tail can affect the observed wavelength dependence and depth of transit light curves. Methods. We developed a new 3D model that ejects sublimating particles from the planet surface to build up a dust tail, assuming it to be optically thin, and used 3D radiative transfer computations that fully treat scattering using the distribution of hollow spheres (DHS) method, to generate transit light curves between 0.45 and 2.5 $\mu$m. Results. We show that the transit depth is wavelength independent for optically thick tails, potentially explaining why only some observations indicate a wavelength dependence. From the 3D nature of our simulated tails, we show that their transit cross-sections are related to the component of particle ejection velocity perpendicular to the planet's orbital plane and use this to derive a minimum ejection velocity of 1.2 kms$^{-1}$. To fit the average transit depth of Kepler-1520 b of 0.87%, we require a high dust mas-loss rate of 7 $-$ 80 M$_\oplus$ Gyr$^{-1}$ which implies planet lifetimes that may be inconsistent with the observed sample. Therefore, these mass-loss rates should be considered to be upper limits.Comment: 22 pages, 22 figures, accepted for publication in A&

Dusty tails of evaporating exoplanets. II. Physical modelling of the KIC 12557548b light curve

Evaporating rocky exoplanets, such as KIC 12557548b, eject large amounts of dust grains, which can trail the planet in a comet-like tail. When such objects occult their host star, the resulting transit signal contains information about the dust in the tail. We aim to use the detailed shape of the Kepler light curve of KIC 12557548b to constrain the size and composition of the dust grains that make up the tail, as well as the mass loss rate of the planet. Using a self-consistent numerical model of the dust dynamics and sublimation, we calculate the shape of the tail by following dust grains from their ejection from the planet to their destruction due to sublimation. From this dust cloud shape, we generate synthetic light curves (incorporating the effects of extinction and angle-dependent scattering), which are then compared with the phase-folded Kepler light curve. We explore the free-parameter space thoroughly using a Markov chain Monte Carlo method. Our physics-based model is capable of reproducing the observed light curve in detail. Good fits are found for initial grain sizes between 0.2 and 5.6 micron and dust mass loss rates of 0.6 to 15.6 M_earth/Gyr (2-sigma ranges). We find that only certain combinations of material parameters yield the correct tail length. These constraints are consistent with dust made of corundum (Al2O3), but do not agree with a range of carbonaceous, silicate, or iron compositions. Using a detailed, physically motivated model, it is possible to constrain the composition of the dust in the tails of evaporating rocky exoplanets. This provides a unique opportunity to probe to interior composition of the smallest known exoplanets.Comment: 18 pages, 11 figures, A&A accepte

Making good citizens : national identity, religion and Liberalism among the Irish elite c.1800-1850.

SIGLEAvailable from British Library Document Supply Centre-DSC:DX202319 / BLDSC - British Library Document Supply CentreGBUnited Kingdo

Spectroscopic Transit Search: a self-calibrating method for detecting planets around bright stars

We search for transiting exoplanets around the star $\beta$ Pictoris using high resolution spectroscopy and Doppler imaging that removes the need for standard star observations. These data were obtained on the VLT with UVES during the course of an observing campaign throughout 2017 that monitored the Hill sphere transit of the exoplanet $\beta$ Pictoris b. We utilize line profile tomography as a method for the discovery of transiting exoplanets. By measuring the exoplanet distortion of the stellar line profile, we remove the need for reference star measurements. We demonstrate the method with white noise simulations, and then look at the case of $\beta$ Pictoris, which is a $\delta$ Scuti pulsator. We describe a method to remove the stellar pulsations and perform a search for any transiting exoplanets in the resultant data set. We inject fake planet transits with varying orbital periods and planet radii into the spectra and determine the recovery fraction. In the photon noise limited case we can recover planets down to a Neptune radius with an $\sim$80% success rate, using an 8 m telescope with a $R\sim 100,000$ spectrograph and 20 minutes of observations per night. The pulsations of $\beta$ Pictoris limit our sensitivity to Jupiter-sized planets, but a pulsation removal algorithm improves this limit to Saturn-sized planets. We present two planet candidates, but argue that their signals are most likely caused by other phenomena. We have demonstrated a method for searching for transiting exoplanets that (i) does not require ancillary calibration observations, (ii) can work on any star whose rotational broadening can be resolved with a high spectral dispersion spectrograph and (iii) provides the lowest limits so far on the radii of transiting Jupiter-sized exoplanets around $\beta$ Pictoris with orbital periods from 15 days to 200 days with >50% coverage.Comment: Accepted for publication in A&A, 8 pages, 8 figures. The Github repository can be found at https://github.com/lennartvansluijs/Spectroscopic-Transit-Searc

Search for an exosphere in sodium and calcium in the transmission spectrum of exoplanet 55 Cancri e

[Abridged] The aim of this work is to search for an absorption signal from exospheric sodium (Na) and singly ionized calcium (Ca$^+$) in the optical transmission spectrum of the hot rocky super-Earth 55 Cancri e. Although the current best-fitting models to the planet mass and radius require a possible atmospheric component, uncertainties in the radius exist, making it possible that 55 Cancri e could be a hot rocky planet without an atmosphere. High resolution (R$\sim$110000) time-series spectra of five transits of 55 Cancri e, obtained with three different telescopes (UVES/VLT, HARPS/ESO 3.6m & HARPS-N/TNG) were analysed. Targeting the sodium D lines and the calcium H and K lines, the potential planet exospheric signal was filtered out from the much stronger stellar and telluric signals, making use of the change of the radial component of the orbital velocity of the planet over the transit from -57 to +57 km/sec. Combining all five transit data sets, we detect a signal potentially associated with sodium in the planet exosphere at a statistical significance level of 3$\sigma$. Combining the four HARPS transits that cover the calcium H and K lines, we also find a potential signal from ionized calcium (4.1 $\sigma$). Interestingly, this latter signal originates from just one of the transit measurements - with a 4.9$\sigma$ detection at this epoch. Unfortunately, due to the low significance of the measured sodium signal and the potentially variable Ca$^+$ signal, we estimate the p-values of these signals to be too high (corresponding to <4$\sigma$) to claim unambiguous exospheric detections. By comparing the observed signals with artificial signals injected early in the analysis, the absorption by Na and Ca$^+$ are estimated to be at a level of approximately 2.3$\times 10^{-3}$ and 7.0$\times 10^{-2}$ respectively, relative to the stellar spectrum.Comment: 15 pages, 8 figures, submission updated after English language editing, submission updated to correct a mistaken cross-reference noticed in A&A proo