A Corona Australis cloud filament seen in NIR scattered light II: Comparison with sub-millimeter data

We study a northern part of the Corona Australis molecular cloud that consists of a filament and a dense sub-millimetre core inside the filament. Our aim is to measure dust temperature and sub-mm emissivity within the region. We also look for confirmation that near-infrared (NIR) surface brightness can be used to study the structure of even very dense clouds. We extend our previous NIR mapping south of the filament. The dust colour temperatures are estimated using Spitzer 160um and APEX/Laboca 870um maps. The column densities derived based on the reddening of background stars, NIR surface brightness, and thermal sub-mm dust emission are compared. A three dimensional toy model of the filament is used to study the effect of anisotropic illumination on near-infrared surface brightness and the reliability of dust temperature determination. Relative to visual extinction, the estimated emissivity at 870um is kappa(870) = (1.3 +- 0.4) x 10^{-5} 1/mag. This is similar to the values found in diffuse medium. A significant increase in the sub-millimetre emissivity seems to be excluded. In spite of saturation, NIR surface brightness was able to accurately pinpoint, and better than measurements of the colour excesses of background stars, the exact location of the column density maximum. Both near- and far-infrared data show that the intensity of the radiation field is higher south of the filament.Comment: 9 pages, 9 figures, accepted to A&

Properties of dust in the high-latitude translucent cloud L1780 I: Spatially distinct dust populations and increased dust emissivity from ISO observations

We have analyzed the properties of dust in the high galactic latitude translucent cloud Lynds 1780 using ISOPHOT maps at 100 and 200 micrometers and raster scans at 60, 80, 100, 120, 150 and 200 micrometers. In far-infrared (FIR) emission, the cloud has a single core that coincides with the maxima of visual extinction and 200um optical depth. At the resolution of 3.0 arcmin, the maximum visual extinction is 4.0 mag. At the cloud core, the minimum temperature and the maximum 200um optical depth are 14.9+/-0.4 K and 2.0+/-0.2x10^{-3}, respectively, at the resolution of 1.5 arcmin. The cloud mass is estimated to be 18M_{SUN}. The FIR observations, combined with IRAS observations, suggest the presence of different, spatially distinct dust grain populations in the cloud: the FIR core region is the realm of the "classical" large grains, whereas the very small grains and the PAHs have separate maxima on the Eastern side of the cold core, towards the "tail" of this cometary-shaped cloud. The color ratios indicate an overabundance of PAHs and VSGs in L1780. Our FIR observations combined with the optical extinction data indicate an increase of the emissivity of the big grain dust component in the cold core, suggesting grain coagulation or some other change in the properties of the large grains. Based on our observations, we also address the question, to what extent the 80um emission and even the 100um and the 120um emission contain a contribution from the small-grain component.Comment: 12 pages, 9 figures, minor changes, one table adde

A Corona Australis cloud filament seen in NIR scattered light I. Comparison with extinction of background stars

With current near-infrared (NIR) instruments the near-infrared light scattered from interstellar clouds can be mapped over large areas. The surface brightness carries information on the line-of-sight dust column density. Therefore, scattered light could provide an important tool to study mass distribution in quiescent interstellar clouds at a high, even sub-arcsecond resolution. We wish to confirm the assumption that light scattering dominates the surface brightness in all NIR bands. Furthermore, we want to show that scattered light can be used for an accurate estimation of dust column densities in clouds with Av in the range 1-15mag. We have obtained NIR images of a quiescent filament in the Corona Australis molecular cloud. The observations provide maps of diffuse surface brightness in J, H, and Ks bands. Using the assumption that signal is caused by scattered light we convert surface brightness data into a map of dust column density. The same observations provide colour excesses for a large number of background stars. These data are used to derive an extinction map of the cloud. The two, largely independent tracers of the cloud structure are compared. Results. In regions below Av=15m both diffuse surface brightness and background stars lead to similar column density estimates. The existing differences can be explained as a result of normal observational errors and bias in the sampling of extinctions provided by the background stars. There is no indication that thermal dust emission would have a significant contribution even in the Ks band. The results show that, below Av=15mag, scattered light does provide a reliable way to map cloud structure. Compared with the use of background stars it can also in practice provide a significantly higher spatial resolution.Comment: 14 pages, 15 figures, accepted to A&A, the version includes small changes in the text and an added appendi

R-h-erythropoietin counteracts the inhibition of in vitro erythropoiesis by tumour necrosis factor alpha in patients with rheumatoid arthritis

Anaemia of chronic disease (ACD) is a common extra-articular manifestation of rheumatoid arthritis (RA). Tumour necrosis factor alpha (TNFα) plays an important role in the development of ACD. The objective of the present study was to assess inhibition of in vitro colony-forming unit erythrocyte (CFUe) and blast-forming unit erythrocyte (BFUe) growth by TNFα and to examine whether this suppression could be counteracted by adding increasing concentrations of recombinant human erythropoietin (EPO) (r-h-EPO) to bone marrow cultures of RA patients with ACD and without anaemia (controls). Bone marrow cells of RA patients with ACD and control patients were cultured. The cultures were incubated with increasing concentrations of r-h-EPO (0.25; 0.5; 1; 2 U/ml), each in combination with increasing quantities of TFNα (0; 50; 100; 200; 400 U/ml). CFUe and BFUe were assessed after 7 and 14 days, respectively. Dose-dependent inhibition of BFUe and CFUc by increasing concentrations of TNFα was observed in ACD and controls. Regarding CFUe (ACD patients) incubated with 0.25 U/ml EPO, 50 U/ml TNFα caused 28% suppression compared to cultures without TNFα. Increasing the concentration of r-h-EPO from 0.25 U/ml to 2 U/ml completely restored the number of CFUe. A similar pattern was observed in BFUe growth in both groups. These data demonstrated the suppressive effects of TNFα on erythropoiesis in vitro and that the suppresed erythropoiesis could be partly corrected by the addition of excess r-h-EPO to the cultures. No significant differences were observed between ACD and control RA patients. This in vitro model may help explain the clinical response to r-h-EPO therapy as documented in RA patients with ACD

An introductory view on archaeoastronomy

Archaeoastronomy is still a marginalised topic in academia and is described by the Sophia Centre, the only UK institution offering a broader MA containing this field, as ‘the study of the incorporation of celestial orientation, alignments or symbolism in human monuments and architecture’. By many it is associated with investigating prehistoric monuments such as Stonehenge and combining astronomy and archaeology. The following will show that archaeoastronomy is far more than just an interdisciplinary field linking archaeology and astronomy. It merges aspects of anthropology, ethno-astronomy and even educational research, and is possibly better described as cultural astronomy. In the past decades it has stepped away from its quite speculative beginnings that have led to its complete rejection by the archaeology community. Overcoming these challenges it embraced full heartedly solid scientific and statistical methodology and achieved more credibility. However, in recent times the humanistic influences of a cultural context motivate a new generation of archaeoastronomers that are modernising this subject; and humanists might find it better described as post-modern archaeoastronomy embracing the pluralism of today’s academic approach to landscape and ancient people

ISO far infrared observations of the high latitude cloud L1642. II. Correlated variations of far-infrared emissivity and temperature of "classical large" dust particles

Our aim is to compare the infrared properties of big, ``classical'' dust grains with visual extinction in the cloud L1642. In particular, we study the differences of grain emissivity between diffuse and dense regions in the cloud. The far-infrared properties of dust are based on large-scale 100um and 200um maps. Extinction through the cloud has been derived by using the star count method at B- and I-bands, and color excess method at J, H and Ks bands. Radiative transfer calculations have been used to study the effects of increasing absorption cross-section on the far-infrared emission and dust temperature. Dust emissivity, measured by the ratio of far-infrared optical depth to visual extinction, tau(far-IR)/A(V), increases with decreasing dust temperature in L1642. There is about two-fold increase of emissivity over the dust temperature range of 19K-14K. Radiative transfer calculations show that in order to explain the observed decrease of dust temperature towards the centre of L1642 an increase of absorption cross-section of dust at far-IR is necessary.This temperature decrease cannot be explained solely by the attenuation of interstellar radiation field. Increased absorption cross-section manifests itself also as an increased emissivity. We find that, due to temperature effects, the apparent value of optical depth tau(far-IR), derived from 100um and 200um intensities, is always lower than the true optical depth.Comment: 11 pages, 9 figures. Accepted for publication in A&

IgM memory B cells: a mouse/human paradox

Humoral memory is maintained by two types of persistent cells, memory B cells and plasma cells, which have different phenotypes and functions. Long-lived plasma cells can survive for a lifespan within a complex niche in the bone marrow and provide continuous protective serum antibody levels. Memory B cells reside in secondary lymphoid organs, where they can be rapidly mobilized upon a new antigenic encounter. Surface IgG has long been taken as a surrogate marker for memory in the mouse. Recently, however, we have brought evidence for a long-lived IgM memory B cell population in the mouse, while we have also argued that, in humans, these same cells are not classical memory B cells but marginal zone (MZ) B cells which, as opposed to their mouse MZ counterpart, recirculate and carry a mutated B cell receptor. In this review, we will discuss these apparently paradoxical results

Sex Bias in Pathogenesis of Autoimmune Neuroinflammation: Relevance for Dimethyl Fumarate Immunomodulatory/Anti-oxidant Action

In the present study, upon showing sexual dimorphism in dimethyl fumarate (DMF) efficacy to moderate the clinical severity of experimental autoimmune encephalomyelitis (EAE) in Dark Agouti rats, cellular and molecular substrate of this dimorphism was explored. In rats of both sexes, DMF administration from the day of immunization attenuated EAE severity, but this effect was more prominent in males leading to loss of the sexual dimorphism observed in vehicle-administered controls. Consistently, in male rats, DMF was more efficient in diminishing the number of CD4+ T lymphocytes infiltrating spinal cord (SC) and their reactivation, the number of IL-17+ T lymphocytes and particularly cellularity of their highly pathogenic IFN-gamma+GM-CSF+IL-17+ subset. This was linked with changes in SC CD11b+CD45+TCR alpha beta- microglia/proinflammatory monocyte progeny, substantiated in a more prominent increase in the frequency of anti-inflammatory phygocyting CD163+ cells and the cells expressing high surface levels of immunoregulatory CD83 molecule (associated with apoptotic cells phagocytosis and implicated in downregulation of CD4+ T lymphocyte reactivation) among CD11b+CD45+TCR alpha beta- cells in male rat SC. These changes were associated with greater increase in the nuclear factor (erythroid-derived 2)-like 2 expression in male rats administered with DMF. In accordance with the previous findings, DMF diminished reactive nitrogen and oxygen species generation and consistently, SC level of advanced oxidation protein products, to the greater extent in male rats. Overall, our study indicates sex-specificity in the sensitivity of DMF cellular and molecular targets and encourages sex-based clinical research to define significance of sex for action of therapeutic agents moderating autoimmune neuroinflammation-/oxidative stress-related nervous tissue damage

THE GREAT OAK: AN ANNUAL CALENDRIC AND AGRICULTURAL FERTILITY MYTH OF THE BALTIC FINNS

ABSTRACT 'The Great Oak' is one of the most important myths presented in the poetry of the Baltic Finns. The contents of the myth have been formed and reformed in various cultural environments during many different historical periods. In this paper, the myth is analysed and its historical development is reconstructed by investigating its details and by comparing it to other similar myths and the known history of the Finnic peoples. It is shown that 'The Great Oak' is mainly a calendric and agricultural fertility myth related to the annual solar and vegetation cycle. Certain mythemes encountered in many variants of the poem reveal that it was related to slash-and-burn cultivation and the success of the annual agricultural yield, the measure of which was the production of beer for festival and ritual use. It turns out that the poem was sung on the fields of Ritvala in Tavastia in the rites held between the start of the sowing season in May and the midsummer. It is thus shown that the concrete use of the poem was connected to the annual rituals performed to ensure agricultural fertility