Effects of Ribavirin on BHK-21 Cells Acutely or Persistently Infected With Mumps Virus

The effects of ribavirin on BHK-21 cells acutely infected with mumps virus were compared to the effects of the drug on the same cell line persistently infected with mumps virus. Visible cytotoxicity was minimal for both cell types; however, there was an inhibition of cell replication with increasing drug concentrations. Ribavirin had marked antiviral activity against both the acute and persistent infections as determined by an inhibition of hemadsorption plaque formation, decreased immunofluorescence, and a reduction in the release of infectious virus. Even after the drug had been on the persistently infected cells for 72 h, there was still antigen production detectable by immunofluorescence, although the cells no longer hemadsorbed chicken erythrocytes. Ribavirin removal from both types of infection resulted in the renewed synthesis of virus.</jats:p

Digital Literacy: Further Developing Michigan's Twenty-First Century Workforce

The purpose of this Co-Learning Plan was to examine the Information and Communications Technology (ICT) skills or "digital literacy" skills gap and its relationship to workforce and economic development in Michigan

On-Site Technology Training for Small, Rural Michigan Businesses

Connect Michigan has been leading the way to bring the economic and quality of life benefits of broadband to all Michigan residents. This report explored the opportunity for hands-on, on-site technology training for Michigan small businesses and suggests a model for local implementation

Implementación de un sistema de seguridad de la información adaptado al modelo COBIT 5 y la norma ISO 27002 caso: MV Servicios SRL

La investigación tiene como objetivo implementar un sistema de seguridad de la información para mejorar los niveles de confidencialidad, integridad y disponibilidad de la información en la empresa MV Servicios SRL. Se realizó la evaluación de riesgos asociados a los hallazgos de la auditoría, con la finalidad de identificar los riesgos de mayor impacto para la empresa. El sistema de seguridad de la información adaptado fue validado por juicio de expertos aplicado a 8 especialistas. De la evaluación realizada se determinó que la aplicación del sistema elaborado significará una mejora considerable de los niveles de confidencialidad, integridad y disponibilidad de la información en la empresa MV Servicios SRL.The present investigation has as objective implement an information security system to improve the levels of confidentiality, integrity and availability of information in the company MV Services SRL. The risks associated with the audit findings were evaluated in order to identify the risks with the greatest impact on the company. The adapted information security system was validated by expert judgement applied to 8 specialists. From the evaluation carried out it was determined that the application of the elaborated system will mean a considerable improvement of the levels of confidentiality, integrity and availability of the information in the company MV Servicios SRL.Tesi

Taking firms to the stock market : IPOs and the importance of large banks in imperial Germany 1896-1913

Large universal banks played a major role for Germany?s industrialisation because they provided loans to the industry and thereby helped firms to overcome liquidity constraints. Previous research has also argued that they were equally important on the German stock market. The present paper provides quantitative and qualitative evidence that although the market for underwriters was dominated by a small oligopoly of six large banks, there was still perceptible competition, which kept fees and short run profits low. Another interesting finding of the paper is the absence of a signalling effect to investors. Neither underpricing nor the one year performance was different for the IPOs issued by one of the Big Six. Thus, although the German IPO business was in the hands of a small oligopoly, investors did not benefit from the lack of competition. One explanation is that the quality of IPOs on the German stock market of the time was very good in general caused by the competition between underwriters, but also by the tight regulation of underwriting, which ensured the quality of all firms on the German stock market