Object Distribution Networks for World-wide Document Circulation

This paper presents an Object Distribution System (ODS), a distributed system inspired by the ultra-large scale distribution models used in everyday life (e.g. food or newspapers distribution chains). Beyond traditional mechanisms of approaching information to readers (e.g. caching and mirroring), this system enables the publication, classification and subscription to volumes of objects (e.g. documents, events). Authors submit their contents to publication agents. Classification authorities provide classification schemes to classify objects. Readers subscribe to topics or authors, and retrieve contents from their local delivery agent (like a kiosk or library, with local copies of objects). Object distribution is an independent process where objects circulate asynchronously among distribution agents. ODS is designed to perform specially well in an increasingly populated, widespread and complex Internet jungle, using weak consistency replication by object distribution, asynchronous replication, and local access to objects by clients. ODS is based on two independent virtual networks, one dedicated to the distribution (replication) of objects and the other to calculate optimised distribution chains to be applied by the first network

Proteomic studies of marine organism

Comunicaciones a congreso

Proteomic signature of non-alcoholic beverages via combinatorial peptide ligand libraries

Comunicaciones a congreso

An emerging picture of the seed desiccome: confirmed regulators and newcomers identified using transcriptome comparison

Desiccation tolerance (DT) is the capacity to withstand total loss of cellular water. It is acquired during seed filling and lost just after germination. However, in many species, a germinated seed can regain DT under adverse conditions such as osmotic stress. The genes, proteins and metabolites that are required to establish this DT is referred to as the desiccome. It includes both a range of protective mechanisms and underlying regulatory pathways that remain poorly understood. As a first step toward the identification of the seed desiccome of Medicago truncatula, using updated microarrays we characterized the overlapping transcriptomes associated with acquisition of DT in developing seeds and the re-establishment of DT in germinated seeds using a polyethylene glycol treatment (−1.7 MPa). The resulting list contained 740 and 2829 transcripts whose levels, respectively, increased and decreased with DT. Fourty-eight transcription factors (TF) were identified including MtABI3, MtABI5 and many genes regulating flowering transition and cell identity. A promoter enrichment analysis revealed a strong over-representation of ABRE elements together with light-responsive cis-acting elements. In Mtabi5 Tnt1 insertion mutants, DT could no longer be re-established by an osmotic stress. Transcriptome analysis on Mtabi5 radicles during osmotic stress revealed that 13 and 15% of the up-regulated and down-regulated genes, respectively, are mis-regulated in the mutants and might be putative downstream targets of MtABI5 implicated in the re-establishment of DT. Likewise, transcriptome comparisons of the desiccation sensitive Mtabi3 mutants and hairy roots ectopically expressing MtABI3 revealed that 35 and 23% of the up-regulated and down-regulated genes are acting downstream of MtABI3. Our data suggest that ABI3 and ABI5 have complementary roles in DT. Whether DT evolved by co-opting existing pathways regulating flowering and cellular phase transition and cell identity is discussed

Relationship Between Non-Hodgkin's Lymphoma and Blood Levels of Epstein-Barr Virus in Children in North-Western Tanzania: A Case Control Study.

Non-Hodgkin's Lymphomas (NHL) are common in African children, with endemic Burkitt's lymphoma (BL) being the most common subtype. While the role of Epstein-Barr Virus (EBV) in endemic BL is known, no data are available about clinical presentations of NHL subtypes and their relationship to Human Immunodeficiency Virus (HIV) infection and Epstein Barr Virus (EBV) load in peripheral blood of children in north-western, Tanzania. A matched case control study of NHL subtypes was performed in children under 15 years of age and their respective controls admitted to Bugando Medical Centre, Sengerema and Shirati district designated hospitals in north-western, Tanzania, between September 2010 and April 2011. Peripheral blood samples were collected on Whatman 903 filter papers and EBV DNA levels were estimated by multiplex real-time PCR. Clinical and laboratory data were collected using a structured data collection tool and analysed using chi-square, Fisher and Wilcoxon rank sum tests where appropriate. The association between NHL and detection of EBV in peripheral blood was assessed using conditional logistic regression model and presented as odds ratios (OR) and 95% confidence intervals (CI). A total of 35 NHL cases and 70 controls matched for age and sex were enrolled. Of NHLs, 32 had BL with equal distribution between jaw and abdominal tumour, 2 had large B cell lymphoma (DLBCL) and 1 had NHL-not otherwise specified (NHL-NOS). Central nervous system (CNS) presentation occurred only in 1 BL patient; 19 NHLs had stage I and II of disease. Only 1 NHL was found to be HIV-seropositive. Twenty-one of 35 (60%) NHL and 21 of 70 (30%) controls had detectable EBV in peripheral blood (OR = 4.77, 95% CI 1.71 - 13.33, p = 0.003). In addition, levels of EBV in blood were significantly higher in NHL cases than in controls (p = 0.024). BL is the most common childhood NHL subtype in north-western Tanzania. NHLs are not associated with HIV infection, but are strongly associated with EBV load in peripheral blood. The findings suggest that high levels of EBV in blood might have diagnostic and prognostic relevance in African children

Binary green blends of poly(Lactic acid) with poly(butylene adipate-co-butylene terephthalate) and poly(butylene succinate-co-butylene adipate) and their nanocomposites

Poly(lactic acid) (PLA) is the most widely produced biobased, biodegradable and biocompatible polyester. Despite many of its properties are similar to those of common petroleum-based polymers, some drawbacks limit its utilization, especially high brittleness and low toughness. To overcome these problems and improve the ductility and the impact resistance, PLA is often blended with other biobased and biodegradable polymers. For this purpose, poly(butylene adipate-co-butylene terephthalate) (PBAT) and poly(butylene succinate-co-butylene adipate) (PBSA) are very advantageous copolymers, because their toughness and elongation at break are complementary to those of PLA. Similar to PLA, both these copolymers are biodegradable and can be produced from annual renewable resources. This literature review aims to collect results on the mechanical, thermal and morphological properties of PLA/PBAT and PLA/PBSA blends, as binary blends with and without addition of coupling agents. The effect of different compatibilizers on the PLA/PBAT and PLA/PBSA blends properties is here elucidated, to highlight how the PLA toughness and ductility can be improved and tuned by using appropriate additives. In addition, the incorporation of solid nanoparticles to the PLA/PBAT and PLA/PBSA blends is discussed in detail, to demonstrate how the nanofillers can act as morphology stabilizers, and so improve the properties of these PLA-based formulations, especially mechanical performance, thermal stability and gas/vapor barrier properties. Key points about the biodegradation of the blends and the nanocomposites are presented, together with current applications of these novel green materials

The Prosocial Versus Proself Power Holder: How Power Influences Sacrifice in Romantic Relationships

Romantic partners often have to sacrifice their interests to benefit their partner or to maintain the relationship. In the present work, we investigated whether relative power within the relationship plays an important role in determining the extent to which partners are likely to sacrifice. Drawing from both classic theories and recent research on power, we tested two competing predictions on the relationship between power and sacrifice in romantic relationships. We tested whether (a) power is negatively related to sacrifice and (b) power is positively related to sacrifice. Furthermore, we also explored whether the association between power and sacrifice is moderated by commitment and inclusion of the other in the self. To test our hypotheses, we used different methodologies, including questionnaires, diary studies, and videotaped interactions. Results across the five studies (N = 1,088) consistently supported the hypothesis that power is negatively related to tendencies to sacrifice in close relationships

Vitis vinifera - a chemotaxonomic approach: Anthocyanins in the skin

The gaining of new knowledge about varietal differences in grapevines can be useful for the designing of genetic improvement programs. More and more, chemical methods complement ampelographic ones in the study of variability in grapevines. This work is aimed at the anthocyanin profiling of red-coloured grapes, of which ca. 120 cultivars were sampled; among these there were a high number of old Italian vines and 30 Vitis vinifera ssp. silvestris originating from different areas of Italy. Anthocyanins were HPLC separated and quantified with the aid of an inverse phase microbore column and a photodiode detector. Grapevines were numerically separated in groups using as indexes the percentage of the 5 monoglucosides present, the summations of: acetic esters; malvidin-3-monoglucoside-caffeoate plus all 5 p-coumaric esters; as well as a series of relations correlated to certain enzymatic activities necessary for the esterification of glucosides, hydroxylation and methylation in the biosynthesis of several anthocyanins. Data derived from the study of indexes of varietal enzymatic activity enable us to qualify differences between grapevines linked to the synthesis of anthocyanins. The stability of anthocyanic profiles within the same grape variety enables the use of this technique for taxonomic purposes. This research study discusses the use of this technique for classification and analysis of grape phylogenesis. An in-depth look into the relations between cultivated and wild varieties is given

Erratum to: 36th International Symposium on Intensive Care and Emergency Medicine

[This corrects the article DOI: 10.1186/s13054-016-1208-6.]