The impact of schizophrenia and mood disorder risk alleles on emotional problems: investigating change from childhood to middle age

Previous studies find that both schizophrenia and mood disorder risk alleles contribute to adult depression and anxiety. Emotional problems (depression or anxiety) begin in childhood and show strong continuities into adult life; this suggests that symptoms are the manifestation of the same underlying liability across different ages. However, other findings suggest that there are developmental differences in the etiology of emotional problems at different ages. To our knowledge, no study has prospectively examined the impact of psychiatric risk alleles on emotional problems at different ages in the same individuals. Data were analyzed using regression-based analyses in a prospective, population-based UK cohort (the National Child Development Study). Schizophrenia and major depressive disorder (MDD) polygenic risk scores (PRS) were derived from published Psychiatric Genomics Consortium genome-wide association studies. Emotional problems were assessed prospectively at six time points from age 7 to 42 years. Schizophrenia PRS were associated with emotional problems from childhood [age 7, OR 1.09 (1.03–1.15), p = 0.003] to mid-life [age 42, OR 1.10 (1.05–1.17), p < 0.001], while MDD PRS were associated with emotional problems only in adulthood [age 42, OR 1.06 (1.00–1.11), p = 0.034; age 7, OR 1.03 (0.98–1.09), p = 0.228]. Our prospective investigation suggests that early (childhood) emotional problems in the general population share genetic risk with schizophrenia, while later (adult) emotional problems also share genetic risk with MDD. The results suggest that the genetic architecture of depression/anxiety is not static across development

Grad Tests for Your Taste

Operation Pillsbury -this is the name Rosalie Riglin, home economics journalism graduate \u2746, gives her job as Pillsbury Mills\u27 Paris representative. Miss Riglin is working on Pillsbury\u27s European Recipe Service where she collects and tests European recipes which later appear in the Pillsbury advertisements for the benefit of American homemakers. The following is her personal letter about her work

Vicky Anticipates a Social Season

With the promise of the gayest social season in five years, Vicky is eagerly anticipating her holiday wardrobe. She\u27s finding new voluminous air about clothes this year, achieved with rounded shoulders, nipped-in waists and gathered skirts

Performance Characteristics of Airlift Pumps with Vortex Induced by Tangential Fluid Injection

The effect of the swirl component of air injection on the performance of an airlift pump was examined experimentally. An airlift pump is a device that pumps a liquid or slurry using only gas injection. In this study, the liquid used was water and the injected gas was air. The effect of the air swirl was determined by measuring the water discharge from an airlift pump with an air injection nozzle in which the air flow had both axial and tangential components and then repeating the tests with a nozzle with only axial injection. The induced water flow was measured using an orifice meter in the supply pipeline. Tests were run for air pressures ranging from 10 to 30 pounds per square inch, gauge (psig), at flow rates from 5 standard cubic feet per minute (scfm) up the maximum values attainable at the given pressure (usually in the range from 20 to 35 scfm). The nozzle with only axial injection produced a water flow rate that wasequivalent to or better than that induced by the nozzle with swirl. The swirl component of air injection was found to be detrimental to pump performance for all but the smallest air injection flow rate. Optimum efficiency was found for air injection pressures of 10 psig to 15 psig. In addition, the effect of using auxiliary tangential injection of water to create a swirl component in the riser before air injection on the overall capacity (i.e., flow rate) and efficiencyof the pump was examined. Auxiliary tangential water injection was found to have no beneficial effect on the pump capacity or performance in the present system

POW\u27s Eat Foods of Their Dreams

Iowa State returned prisoners of war eat self-selected diets according to Rosalie Rigli

Higher cognitive ability buffers stress-related depressive symptoms in adolescent girls

Stress has been shown to have a causal effect on risk for depression. We investigated the role of cognitive ability as a moderator of the effect of stressful life events on depressive symptoms and whether this varied by gender. Data were analyzed in two adolescent data sets: one representative community sample aged 11–12 years (n = 460) and one at increased familial risk of depression aged 9–17 years (n = 335). In both data sets, a three-way interaction was found whereby for girls, but not boys, higher cognitive ability buffered the association between stress and greater depressive symptoms. The interaction was replicated when the outcome was a diagnosis of major depressive disorder. This buffering effect in girls was not attributable to coping efficacy. However, a small proportion of the variance was accounted for by sensitivity to environmental stressors. Results suggest that this moderating effect of cognitive ability in girls is largely attributable to greater available resources for cognitive operations that offer protection against stress-induced reductions in cognitive processing and cognitive control which in turn reduces the likelihood of depressive symptomatology

Exploring the relationship between depressive symptoms and attainment at school

Rates of depressive symptoms and disorder increase during adolescence and these are associated with a range of negative outcomes both in adolescence and adulthood. One possible pathway to poor outcomes is via low attainment at school. However the association between depressive symptoms and attainment is poorly understood. This thesis explored this association. First, a meta-analysis was conducted on associations between depressive symptoms and subsequent attainment (chapter 2). This found small but significant associations, as well as significant heterogeneity of effect sizes between studies. Second, the temporal direction of this association was investigated using a cross-lagged design (chapter 4). This found depressive symptoms to be associated with a decline in attainment over time. Third, possible mediators of this association were investigated in a 3-stage study design (chapter 5). Low school connectedness, concentration problems, and stressful life events were found to mediate associations between depressive symptoms at baseline and low attainment at follow-up. These studies identified gender, co-occurring conduct problems, and cognitive ability as sources of heterogeneity in the association between depressive symptoms and subsequent low attainment. These sources of heterogeneity were then further investigated. First, latent profile analysis was used to investigate depressive subgroups based on co-occurring conduct problems and symptom severity. Subgroups were identified and there was some evidence of differing associations with attainment and in aetiology. Second, higher cognitive ability was found to buffer the effects of stress on depressive symptoms and disorder in girls (chapter 7) as well as the effects of stress on attainment (chapter 5). Taken together, these findings advance understanding of the association between depressive symptoms and attainment at school. They also suggest specific groups with depressive symptoms that may merit special consideration (e.g. pupils with conduct problems or low cognitive ability) and pathways of importance (e.g. school connectedness)

Longitudinal pathways between mental health difficulties and academic performance during middle childhood and early adolescence

There is a growing appreciation that child functioning in different domains, levels, or systems are interrelated over time. Here, we investigate links between internalizing symptoms, externalizing problems, and academic attainment during middle childhood and early adolescence, drawing on two large data sets (child: mean age 8.7 at enrolment, n = 5,878; adolescent: mean age 11.7, n = 6,388). Using a 2‐year cross‐lag design, we test three hypotheses – adjustment erosion, academic incompetence, and shared risk – while also examining the moderating influence of gender. Multilevel structural equation models provided consistent evidence of the deleterious effect of externalizing problems on later academic achievement in both cohorts, supporting the adjustment‐erosion hypothesis. Evidence supporting the academic‐incompetence hypothesis was restricted to the middle childhood cohort, revealing links between early academic failure and later internalizing symptoms. In both cohorts, inclusion of shared‐risk variables improved model fit and rendered some previously established cross‐lag pathways non‐significant. Implications of these findings are discussed, and study strengths and limitations noted

The importance of a developmental perspective in Psychiatry: what do recent genetic epidemiological findings show?

There is growing appreciation that a developmental perspective is helpful in Psychiatry. However, clinical practice and research, especially in an era of very large sample sizes, often ignore the developmental context. In this perspective piece, we discuss why a developmental view is important in Psychiatry and how recent genetic-epidemiological findings further highlight this. DSM-5 childhood neurodevelopmental disorders such as ADHD, typically onset in early childhood but can persist into adult life; the same ADHD genetic loading appears to contribute across the life course. However, recent longitudinal studies have observed that ADHD symptoms may emerge later during adolescence and adult life in some individuals although the etiology of this late-onset group is unclear. The epidemiology and genetics of depression do not appear to be the same in childhood, adolescence, and adult life. Recent genetic findings further highlight this. Autistic type problems and irritability also appear to show developmental variation in their genetic etiology. These findings raise the question of whether social communication and irritability have the same meaning at different ages. Schizophrenia typically onsets after adolescence. However, it is commonly preceded by childhood antecedents that do not resemble schizophrenia itself but do appear to index schizophrenia genetic liability. We conclude that there is a need for clinicians and scientists to adopt a developmental perspective in clinical practice and research by considering age-at-onset and changes over time as well as different developmental periods when interpreting clinical symptoms