An interactive framework for the evaluation and detection of stereoacuity threshold under ambient lighting

Objective: Our study aims to provide a novel framework for the continuous evaluation of stereoacuity under ambient lighting conditions using Bayesian inference. Methods: We applied a combination of psychophysical and expected entropy minimization procedures for the computation of a continuous stereoacuity threshold. Subsequently, we evaluated the effect of ambient lighting during stereoacuity testing (ST) by adopting a bisection-matching based adaptive gamma calibration (AGC). Participants ($N=187$) including visually healthy controls ($N=51$), patients with Intermittent Divergent Squint (IDS; $N=45$), and controls with induced anisometropia (IA; $N=91$) performed ST with and without AGC under two lighting conditions: completely dark (20 cd/m$^2$) and normally lit (130 cd/m$^2$) rooms. Results: Our framework demonstrated "excellent" reliability ($> 0.9$) and a positive correlation with TNO (a clinical stereo test), regardless of whether AGC was conducted. However, when AGC is not performed, significant differences (Friedman $X_{r}^{2} = 28.015$; $p<0.00001$; Bland-Altman bias: 30 arc-sec) were found in stereoacuity thresholds between dark and light conditions for participants with IDS and IA. Controls are unaffected by AGC and yield a similar stereoacuity threshold under both lighting conditions. Conclusion: Our study proves that stereoacuity threshold is significantly deviated particularly in participants with IDS or IA stereo-deficits if ambient lighting is not taken into consideration. Moreover, our framework provides a quick (approximately 5-10 minutes) assessment of stereoacuity threshold and can be performed within 30 ST and 15 AGC trials. Significance: Our test is useful in planning treatments and monitoring prognosis for patients with stereo-deficits by accurately assessing stereovision

Patients Prefer a Virtual Reality Approach Over a Similarly Performing Screen-Based Approach for Continuous Oculomotor-Based Screening of Glaucomatous and Neuro-Ophthalmological Visual Field Defects

Standard automated perimetry (SAP) is the gold standard for evaluating the presence of visual field defects (VFDs). Nevertheless, it has requirements such as prolonged attention, stable fixation, and a need for a motor response that limit application in various patient groups. Therefore, a novel approach using eye movements (EMs) – as a complementary technique to SAP – was developed and tested in clinical settings by our group. However, the original method uses a screen-based eye-tracker which still requires participants to keep their chin and head stable. Virtual reality (VR) has shown much promise in ophthalmic diagnostics – especially in terms of freedom of head movement and precise control over experimental settings, besides being portable. In this study, we set out to see if patients can be screened for VFDs based on their EM in a VR-based framework and if they are comparable to the screen-based eyetracker. Moreover, we wanted to know if this framework can provide an effective and enjoyable user experience (UX) compared to our previous approach and the conventional SAP. Therefore, we first modified our method and implemented it on a VR head-mounted device with built-in eye tracking. Subsequently, 15 controls naïve to SAP, 15 patients with a neuro-ophthalmological disorder, and 15 glaucoma patients performed three tasks in a counterbalanced manner: (1) a visual tracking task on the VR headset while their EM was recorded, (2) the preceding tracking task but on a conventional screen-based eye tracker, and (3) SAP. We then quantified the spatio-temporal properties (STP) of the EM of each group using a cross-correlogram analysis. Finally, we evaluated the human–computer interaction (HCI) aspects of the participants in the three methods using a user-experience questionnaire. We find that: (1) the VR framework can distinguish the participants according to their oculomotor characteristics; (2) the STP of the VR framework are similar to those from the screen-based eye tracker; and (3) participants from all the groups found the VR-screening test to be the most attractive. Thus, we conclude that the EM-based approach implemented in VR can be a user-friendly and portable companion to complement existing perimetric techniques in ophthalmic clinics

Unifying Structure and Function Towards a Comprehensive Macular Evaluation in Eye Disorders: A Multi-Modal Approach Using Microperimetry and Optical Coherence Tomography

ObjectiveWe present a new automatic and comprehensive framework to evaluate retinal sub-layer thickness and visual sensitivity at precise retinal locations through multi-modal registration of confocal scanning laser ophthalmoscope (cSLO) images obtained separately from an optical coherence tomography (OCT) device and a microperimeter.MethodsWe map consecutive B-scans onto the cSLO images after accounting for eye motion. Next, we coarsely register the SLO-microperimetry and cSLO-OCT images using SIFT, followed by precise elastic image registration. Subsequently, we ensure the quality of the co-registered images through single-particle and object tracking of the warped microperimetry test locations. Finally, the retinal thickness is queried from the segmented retinal layers in the co-registered space. A manual mode involving projective transformation accounting for perspective distortions in the images arising from the two modalities is also included.ResultsValidation using retinal images of 8 adults with albinism, 16 adults with amblyopia, 3 adults with macular diseases, and 15 visually healthy adults showed results with excellent reliability.ConclusionThe proposed framework enables the evaluation of retinal thickness by utilizing precise structural and functional relationships of the eye through a self-assessing multi-tiered approach.SignificanceOur framework lays the foundation towards a comprehensive structure-function assessment of the macular region in various eye disorders

Eye-Movement-Based Assessment of the Perceptual Consequences of Glaucomatous and Neuro-Ophthalmological Visual Field Defects

Purpose: Assessing the presence of visual field defects (VFD) through procedures such as perimetry is an essential aspect of the management and diagnosis of ocular disorders. However, even the latest perimetric methods have shortcomings & mdash;a high cognitive demand and requiring prolonged stable fixation and feedback through a button response. Consequently, an approach using eye movements (EM)& mdash;as a natural response & mdash;has been proposed as an alternate way to evaluate the presence of VFD. This approach has given good results for computer-simulated VFD. However, its use in patients is not well documented yet. Here we use this new approach to quantify the spatiotemporal properties (STP) of EM of various patients suffering from glaucoma and neuro-ophthalmological VFD and controls. Methods: In total, 15 glaucoma patients, 37 patients with a neuro-ophthalmological disorder, and 21 controls performed a visual tracking task while their EM were being recorded. Subsequently, the STP of EM were quantified using a cross-correlogram analysis. Decision trees were used to identify the relevant STP and classify the populations. Results: We achieved a classification accuracy of 94.5% (TPR/sensitivity = 96%, TNR/specificity = 90%) between patients and controls. Individually, the algorithm achieved an accuracy of 86.3% (TPR for neuro-ophthalmology [97%], glaucoma [60%], and controls [86%]). The STP of EM were highly similar across two different control cohorts. Conclusions: In an ocular tracking task, patients with VFD due to different underlying pathology make EM with distinctive STP. These properties are interpretable based on different clinical characteristics of patients and can be used for patient classification. Translational Relevance: Our EM-based screening tool may complement existing perimetric techniques in clinical practice. Superscript/Subscript Available ABSTRACT Purpose: Assessing the presence of visual field defects (VFD) through procedures such as perimetry is an essential aspect of the management and diagnosis of ocular disorders. However, even the latest perimetric methods have shortcomings?a high cognitive demand and requiring prolonged stable fixation and feedback through a button response. Consequently, an approach using eye movements (EM)?as a natural response?has been proposed as an alternate way to evaluate the presence of VFD. This approach has given good results for computer-simulated VFD. However, its use in patients is not well documented yet. Here we use this new approach to quantify the spatiotemporal properties (STP) of EM of various patients suffering from glaucoma and neuro-ophthalmological VFD and controls. Methods: In total, 15 glaucoma patients, 37 patients with a neuro-ophthalmological disorder, and 21 controls performed a visual tracking task while their EM were being recorded. Subsequently, the STP of EM were quantified using a cross-correlogram analysis. Decision trees were used to identify the relevant STP and classify the populations. Results: We achieved a classification accuracy of 94.5% (TPR/sensitivity = 96%, TNR/specificity = 90%) between patients and controls. Individually, the algorithm achieved an accuracy of 86.3% (TPR for neuro-ophthalmology [97%], glaucoma [60%], and controls [86%]). The STP of EM were highly similar across two different control cohorts

A method for continuous evaluation of three-dimensional (3d) motion perception and a system thereof

Disclosed herein is a technique for continuous evaluation of three-dimensional (3D) motion perception. The technique comprises setting one or more stimulus parameters related to at least one virtual object to be projected on a head mounted device (HMD) worn by a user, selecting at least one virtual background for the at least one virtual object, setting one or more parameters related to the at least one virtual background, initiating a motion of the at least one virtual object on the HMD based on the one or more stimulus parameters for a plurality of pre-defined iterations having a pre-defined time-period, continuously acquiring one or more 3D data perceived by at least one eye of the user during each of the plurality of pre-defined iterations, continuously determining the 3D motion perception of the user based on the acquired one or more 3D data

Distinct rich and diverse clubs regulate coarse and fine binocular disparity processing: Evidence from stereoscopic task-based fMRI

Summary: While cortical regions involved in processing binocular disparities have been studied extensively, little is known on how the human visual system adapts to changing disparity magnitudes. In this paper, we investigate causal mechanisms of coarse and fine binocular disparity processing using fMRI with a clinically validated, custom anaglyph-based stimulus. We make use of Granger causality and graph measures to reveal the existence of distinct rich and diverse clubs across different disparity magnitudes. We demonstrate that Middle Temporal area (MT) plays a specialized role with overlapping rich and diverse characteristics. Next, we show that subtle interhemispheric differences exist across various brain regions, despite an overall right hemisphere dominance. Finally, we pass the graph measures through the decision tree and found that the diverse clubs outperform rich clubs in decoding disparity magnitudes. Our study sets the stage for conducting further investigations on binocular disparity processing, particularly in the context of neuro-ophthalmic disorders with binocular impairments

A framework for the continuous evaluation of 3D Motion Perception in Virtual Reality

OBJECTIVE: We present a novel framework for the detection and continuous evaluation of 3D motion perception by deploying a virtual reality environment with built-in eye tracking.METHODS: We created a biologically-motivated virtual scene that involved a ball moving in a restricted Gaussian random walk against a background of 1/f noise. Sixteen visually healthy participants were asked to follow the moving ball while their eye movements were monitored binocularly using the eye tracker. We calculated the convergence positions of their gaze in 3D using their fronto-parallel coordinates and linear least-squares optimization. Subsequently, to quantify 3D pursuit performance, we employed a first-order linear kernel analysis known as the Eye Movement Correlogram technique to separately analyze the horizontal, vertical and depth components of the eye movements. Finally, we checked the robustness of our method by adding systematic and variable noise to the gaze directions and re-evaluating 3D pursuit performance.RESULTS: We found that the pursuit performance in the motion-through depth component was reduced significantly compared to that for fronto-parallel motion components. We found that our technique was robust in evaluating 3D motion perception, even when systematic and variable noise was added to the gaze directions.CONCLUSION: The proposed framework enables the assessment of 3D Motion perception by evaluating continuous pursuit performance through eye-tracking.SIGNIFICANCE: Our framework paves the way for a rapid, standardized and intuitive assessment of 3D motion perception in patients with various eye disorders.</p