The right to unionise, the right to bargain and the right to democratic policing

This (normative) article explores the importance of police unions in the quest for democratic policing. The authors argue that if we are to expect police to behave democratically, it is important for police themselves to experience democratic engagement within the organizations in which they work. That is, if police are expected to defend democracy, they should not be denied basic democratic rights such as the right to collective bargaining and the right to freedom of association. The authors contend that police unions, through networking with other social justice groupings and through encouraging democratic practice, constitute a real forum for the promotion of democratic policing. For this potential to be reached, however, police unions need to identify with broader labor movement trends toward community unionism

Representative sequencing: Unbiased sampling of solid tumor tissue

International audienceAlthough thousands of solid tumors have been sequenced to date, a fundamental under-sampling bias isinherent in current methodologies. This is caused by a tissue sample input of fixed dimensions (e.g., 6 mmbiopsy), which becomes grossly under-powered as tumor volume scales. Here, we demonstrate representative sequencing (Rep-Seq) as a new method to achieve unbiased tumor tissue sampling. Rep-Seq uses fixed residual tumor material, which is homogenized and subjected to next-generation sequencing. Analysis of intratumor tumor mutation burden (TMB) variability shows a high level of misclassification using current single-biopsy methods, with 20% of lung and 52% of bladder tumors having at least one biopsy with high TMB butlow clonal TMB overall. Misclassification rates by contrast are reduced to 2% (lung) and 4% (bladder) when a more representative sampling methodology is used. Rep-Seq offers an improved sampling protocol for tumor profiling, with significant potential for improved clinical utility and more accurate deconvolution of clonal structure