The perception of psychosocial risks and work-related stress in relation to job insecurity and gender differences: a cross-sectional study

Introduction.The perception of psychosocial risks exposesworkers to developwork-related stress. Recently the attention of scientific research has focused on a psychosocial risk already identified as “job insecurity” that regards the “overall concern about the continued existence of the job in the future” and that also depends onworker’s perception, different for each gender. Aimof the Study. The aim of this cross sectional study is to show if job insecurity, in the formof temporary contracts, can influence the perception of psychosocial risks and therefore increase worker’s vulnerability to work-related stress and how the magnitude of this effect differs between genders. Materials and Methods. 338 administrative technical workers (113 males and 225 females) were administered a questionnaire, enquiring contract typology (permanent or temporary contracts), and the Health Safety Executive questionnaire to assess work-related stress. The Health Safety Executive Analysis Tool software was used to process collected questionnaires and theWilcoxon rank-sum test was used to evaluate the statistical significance of the differences obtained. Results. Workers with temporary contracts obtained lower scores than workers with permanent contracts in all the domains explored by theHealth Safety Executive Analysis questionnaire, statistically significant (P<0,05). The female workers obtained lower scores than male workers in all domains explored by the Health Safety Executive questionnaire. Conclusions. Authors conclude that perception of psychosocial risks can be influenced by job insecurity, in the form of temporary contracts, and increases worker’s vulnerability to work-related stress and differs between genders

Olimpiada Internacional de Ciencias de la Tierra (IESO): Una oportunidad a la Geología

Olimpiada Internacional de Ciencias de la Tierra: Una oportunidad a la Geología

The geological characterization of landscape in majjor TV Series: a suggested approach to involve the public in the geological heritage promotion.

The characterization of natural and cultural heritage using popular entertainment, such as TV movies and series, can become an effective and original way to involve society in protecting territory and enhancing local development, thanks to the dissemination of knowledge. The aim is to make the complex aspects of landscape related to its geological and ecological assessment understandable to the public. The tools here proposed are the episodes of the TV series “Inspector Montalbano” filmed in Sicily. The stories, written by Andrea Camilleri, are located in Sicily (the biggest Italian island in the southern Mediterranean Sea), in particular with some World Heritage Sites. The natural and cultural landscapes, which provide fascinating scenery to the films, represent a meaning in the representation of the plot. At the same time, if recognized and understood, they become part of the cultural heritage of each component of the local community and of society. The cognitive process activates a virtuous circle revitalizing the links between humanity and environment. Moreover, it promotes a creative participation of the public in new policies, oriented towards sustainable development, and tourism—especially geotourism and ecotourism—becomes an important resource, especially in these times of crisis

Drug repositioning : a machine-learning approach through data integration

Existing computational methods for drug repositioning either rely only on the gene expression response of cell lines after treatment, or on drug-to-disease relationships, merging several information levels. However, the noisy nature of the gene expression and the scarcity of genomic data for many diseases are important limitations to such approaches. Here we focused on a drug-centered approach by predicting the therapeutic class of FDA-approved compounds, not considering data concerning the diseases. We propose a novel computational approach to predict drug repositioning based on state-of-the-art machine-learning algorithms. We have integrated multiple layers of information: i) on the distances of the drugs based on how similar are their chemical structures, ii) on how close are their targets within the protein-protein interaction network, and iii) on how correlated are the gene expression patterns after treatment. Our classifier reaches high accuracy levels (78%), allowing us to re-interpret the top misclassifications as re-classifications, after rigorous statistical evaluation. Efficient drug repurposing has the potential to significantly impact the whole field of drug development. The results presented here can significantly accelerate the translation into the clinics of known compounds for novel therapeutic uses

What unrelated hematopoietic stem cell transplantation in thalassemia taught us about transplant immunogenetics

Although the past few decades have shown an improvement in the survival and complication-free survival rates in patients with beta-thalassemia major and gene therapy is already at an advanced stage of experimentation, hematopoietic stem cell transplantation (HSCT) continues to be the only effective and realistic approach to the cure of this chronic nonmalignant disease. Historically, human leukocyte antigen (HLA)-matched siblings have been the preferred source of donor cells owing to superior outcomes compared with HSCT from other sources. Nowadays, the availability of an international network of voluntary stem cell donor registries and cord blood banks has significantly increased the odds of finding a suitable HLA matched donor. Stringent immunogenetic criteria for donor selection have made it possible to achieve overall survival (OS) and thalassemia-free survival (TFS) rates comparable to those of sibling transplants. However, acute and chronic graft-versus-host disease (GVHD) remains the most important complication in unrelated HSCT in thalassemia, leading to significant rates of morbidity and mortality for a chronic non-malignant disease. A careful immunogenetic assessment of donors and recipients makes it possible to individualize appropriate strategies for its prevention and management. This review provides an overview of recent insights about immunogenetic factors involved in GVHD, which seem to have a potential role in the outcome of transplantation for thalassemia

Supervivencia y perdurabilidad del Código Civil

Fil: Alterini, Atilio Aníbal. Universidad de Buenos Aires. Facultad de Derecho. Cátedra Derecho Civil. Buenos Aires, ArgentinaFil: López del Carril, Nelson Julio. Universidad de Buenos Aires. Facultad de Derecho. Cátedra Derecho Civil I. Buenos Aires, ArgentinaFil: Greco, Roberto Ernesto. Universidad de Buenos Aires. Facultad de Derecho. Cátedra Derecho Civil II. Buenos Aires, ArgentinaFil: Gastaldi, José María. Universidad de Buenos Aires. Facultad de Derecho. Cátedra Derecho Civil III. Buenos Aires, ArgentinaFil: Russomanno, Mario César. Universidad de Buenos Aires. Facultad de Derecho. Cátedra Derecho Romano. Buenos Aires, ArgentinaFil: Maffia, Jorge O. Universidad Nacional de la Plata. Facultad de Ciencias Jurídicas y Sociales. La Plata, ArgentinaFil: Belluscio, Augusto César. Universidad de Buenos Aires. Facultad de Derecho. Cátedra Derecho Civil V. Buenos Aires, Argentin

Differences in DNA methylation profile of Th1 and Th2 cytokine genes are associated with tolerance acquisition in children with IgE-mediated cow's milk allergy

Epigenetic changes in DNA methylation could regulate the expression of several allergy-related genes. We investigated whether tolerance acquisition in children with immunoglobulin E (IgE)-mediated cow's milk allergy (CMA) is characterized by a specific DNA methylation profile of Th2 (IL-4, IL-5) and Th1 (IL-10, IFN-γ)-associated cytokine genes