SARS CoV subunit vaccine: Antibodymediated neutralisation and enhancement

1. A SARS vaccine was produced based on recombinant native full-length Spike-protein trimers (triSpike) and efficient establishment of a vaccination procedure in rodents. 2. Antibody-mediated enhancement of SARS-CoV infection with anti-SARS-CoV Spike immune-serum was observed in vitro. 3. Antibody-mediated infection of SARS-CoV triggers entry into human haematopoietic cells via an FcγR-dependent and ACE2-, pH-, cysteine-protease-independent pathways. 4. The antibody-mediated enhancement phenomenon is not a mandatory component of the humoral immune response elicited by SARS vaccines, as pure neutralising antibody only could be obtained. 5. Occurrence of immune-mediated enhancement of SARS-CoV infection raises safety concerns regarding the use of SARS-CoV vaccine in humans and enables new ways to investigate SARS pathogenesis (tropism and immune response deregulation)

Generation of magnetic field by dynamo action in a turbulent flow of liquid sodium

We report the observation of dynamo action in the VKS experiment, i.e., the generation of magnetic field by a strongly turbulent swirling flow of liquid sodium. Both mean and fluctuating parts of the field are studied. The dynamo threshold corresponds to a magnetic Reynolds number Rm \sim 30. A mean magnetic field of order 40 G is observed 30% above threshold at the flow lateral boundary. The rms fluctuations are larger than the corresponding mean value for two of the components. The scaling of the mean square magnetic field is compared to a prediction previously made for high Reynolds number flows.Comment: 4 pages, 5 figure

Effect of anharmonicities in the critical number of trapped condensed atoms with attractive two-body interaction

We determine the quantitative effect, in the maximum number of particles and other static observables, due to small anharmonic terms added to the confining potential of an atomic condensed system with negative two-body interaction. As an example of how a cubic or quartic anharmonic term can affect the maximum number of particles, we consider the trap parameters and the results given by Roberts et al. [Phys. Rev. Lett. 86, 4211 (2001)]. However, this study can be easily transferred to other trap geometries to estimate anharmonic effects.Comment: Total of 5 pages, 3 figures and 1 table. To appear in Phys. Rev.

Transport of magnetic field by a turbulent flow of liquid sodium

We study the effect of a turbulent flow of liquid sodium generated in the von K\'arm\'an geometry, on the localized field of a magnet placed close to the frontier of the flow. We observe that the field can be transported by the flow on distances larger than its integral length scale. In the most turbulent configurations, the mean value of the field advected at large distance vanishes. However, the rms value of the fluctuations increases linearly with the magnetic Reynolds number. The advected field is strongly intermittent.Comment: 4 pages, 6 figure

A new interferometric study of four exoplanet host stars : {\theta} Cygni, 14 Andromedae, {\upsilon} Andromedae and 42 Draconis

Studying exoplanet host stars is of the utmost importance to establish the link between the presence of exoplanets around various types of stars and to understand the respective evolution of stars and exoplanets. Using the limb-darkened diameter (LDD) obtained from interferometric data, we determine the fundamental parameters of four exoplanet host stars. We are particularly interested in the F4 main-sequence star, {\theta} Cyg, for which Kepler has recently revealed solar-like oscillations that are unexpected for this type of star. Furthermore, recent photometric and spectroscopic measurements with SOPHIE and ELODIE (OHP) show evidence of a quasi-periodic radial velocity of \sim150 days. Models of this periodic change in radial velocity predict either a complex planetary system orbiting the star, or a new and unidentified stellar pulsation mode. We performed interferometric observations of {\theta} Cyg, 14 Andromedae, {\upsilon} Andromedae and 42 Draconis for two years with VEGA/CHARA (Mount Wilson, California) in several three-telescope configurations. We measured accurate limb darkened diameters and derived their radius, mass and temperature using empirical laws. We obtain new accurate fundamental parameters for stars 14 And, {\upsilon} And and 42 Dra. We also obtained limb darkened diameters with a minimum precision of \sim 1.3%, leading to minimum planet masses of Msini=5.33\pm 0.57, 0.62 \pm 0.09 and 3.79\pm0.29 MJup for 14 And b, {\upsilon} And b and 42 Dra b, respectively. The interferometric measurements of {\theta} Cyg show a significant diameter variability that remains unexplained up to now. We propose that the presence of these discrepancies in the interferometric data is caused by either an intrinsic variation of the star or an unknown close companion orbiting around it.Comment: 10 pages + 2 pages appendix, 16 figures, accepted for publication in A&

On the flexibility of the design of Multiple Try Metropolis schemes

The Multiple Try Metropolis (MTM) method is a generalization of the classical Metropolis-Hastings algorithm in which the next state of the chain is chosen among a set of samples, according to normalized weights. In the literature, several extensions have been proposed. In this work, we show and remark upon the flexibility of the design of MTM-type methods, fulfilling the detailed balance condition. We discuss several possibilities and show different numerical results

Resonant control of elastic collisions in an optically trapped Fermi gas of atoms

We have loaded an ultracold gas of fermionic atoms into a far off resonance optical dipole trap and precisely controlled the spin composition of the trapped gas. We have measured a magnetic-field Feshbach resonance between atoms in the two lowest energy spin-states, |9/2, -9/2> and |9/2, -7/2>. The resonance peaks at a magnetic field of 201.5 plus or minus 1.4 G and has a width of 8.0 plus or minus 1.1 G. Using this resonance we have changed the elastic collision cross section in the gas by nearly 3 orders of magnitude.Comment: 4 pages, 3 figure

Pauli Blocking of Collisions in a Quantum Degenerate Atomic Fermi Gas

We have produced an interacting quantum degenerate Fermi gas of atoms composed of two spin-states of magnetically trapped $^{40}$K. The relative Fermi energies are adjusted by controlling the population in each spin-state. Measurements of the thermodynamics reveal the resulting imbalance in the mean energy per particle between the two species, which is as large as a factor of 1.4 at our lowest temperature. This imbalance of energy comes from a suppression of collisions between atoms in the gas due to the Pauli exclusion principle. Through measurements of the thermal relaxation rate we have directly observed this Pauli blocking as a factor of two reduction in the effective collision cross-section in the quantum degenerate regime.Comment: 11 pages, 4 figure

Superchemistry: dynamics of coupled atomic and molecular Bose-Einstein condensates

We analyze the dynamics of a dilute, trapped Bose-condensed atomic gas coupled to a diatomic molecular Bose gas by coherent Raman transitions. This system is shown to result in a new type of `superchemistry', in which giant collective oscillations between the atomic and molecular gas can occur. The phenomenon is caused by stimulated emission of bosonic atoms or molecules into their condensate phases