The trafficking and targeting of P2X receptors

The functional expression of P2X receptors at the plasma membrane is dependent on their trafficking along secretory and endocytic pathways. There are seven P2X receptor subunits, and these differ in their subcellular distributions because they have very different trafficking properties. Some are retained within the endoplasmic reticulum (ER), while others are predominantly at the cell surface or within endosomes and lysosomes. Changes in recruitment of receptors to and from the plasma membrane provides a way of rapidly up- or down-regulating the cellular response to adenosine triphosphate (ATP). An additional layer of regulation is the targeting of these receptors within the membranes of each compartment, which affects their stability, function and the nature of the effector proteins with which they form signaling complexes. The trafficking and targeting of P2X receptors is regulated by their interactions with other proteins and with lipids and we can expect this to vary in a cell-type specific manner and in response to changes in the environment giving rise to differences in receptor activity and function

Nurses attitudes towards patients and communication – therapeutic relationship – qualitative research and systematic review

Abstract Aim: This paper is an extended literature review on the topic of nurses’ effective use of time in Health Communication. It aims to provide for the reader a summary of research regarding how nurses can use the little time available to effectively communicate their care towards their patients Background: Communication of care and compassion are essential aspects of a nurse’s role, yet at present patients are expressing dissatisfaction with the quality of care that is communicated towards them. Nurses claim they are unable to communicate their care due to the time constraints that exist within the busy healthcare system of today. The government have recognised the need for increased communication of compassion but offer no advice on how better to do this within the time limits that nurses operate within. There is a great amount of literature acknowledging the problem of a lack of time to communicate but hardly any research that address the problem directly in an attempt to provide a solution. Method: An extended literature review was the choice method used to conduct this research. This type of method allows a thorough search of all literature relating to the topic from across various disciplines to provide a better understanding of the issue and a summary of the solutions offered within the literature. Databases were systematically searched using various keywords relating to the topic. Each article was then critically appraised and categorised into a theme depending on the article’s content. Findings: Various models and theories emerged supporting the use of brief communication skills to sustain a meaningful therapeutic relationship through the brief interactions nurses are limited to with their patients. Conclusion: Brief interactions between nurses and patients can still be meaningful and build a therapeutic relationship if nurses employ the correct brief communication skills within their practice

Do patients who die from an alcohol-related condition ‘drift’ into areas of greater deprivation? Alcohol-related mortality and health selection theory in Scotland

Background: Health selection has been proposed to explain the patterning of alcohol-related mortality by area deprivation. This study investigated whether persons who die from alcohol-related conditions are more likely to experience social drift than those who die from other causes. Methods: Deaths recorded in Scotland (2013, >21 years) were coded as ‘alcohol-related’ or ‘other’ and by deprivation decile of residence at death. Acute hospital admissions data from 1996 to 2012 were used to provide premortality deprivation data. χ² tests estimated the difference between observed and expected alcohol-related deaths by first Scottish Index of Multiple Deprivation (SIMD) decile and type of death. Logistic regression models were fitted using type of death as the outcome of interest and change in SIMD decile as the exposure of interest. Results: Of 47 012 deaths, 1458 were alcohol-related. Upward and downward mobility was observed for both types of death. An estimated 31 more deaths than expected were classified ‘alcohol-related’ among cases whose deprivation score decreased, while 204 more deaths than expected were classified ‘alcohol-related’ among cases whose initial deprivation ranking was in the four most deprived deciles. Becoming more deprived and first deprivation category were both associated with increased odds of type of death being alcohol-related after adjusting for confounders. Conclusion: This study suggests that health selection appears to contribute less to the deprivation gradient in alcohol-related mortality in Scotland than an individual’s initial area deprivation category

Interview with Mark Robinson: Commonwealth Oral History Project

Interview with Mark Robinson, conducted 17 July 2013 and 8 August 2013 as part of the Commonwealth Oral History Project. The project aims to produce a unique digital research resource on the oral history of the Commonwealth since 1965 through sixty oral history interviews with leading figures in the recent history of the organisation. It will provide an essential research tool for anyone investigating the history of the Commonwealth and will serve to promote interest in and understanding of the organisation. Biography: Robinson, Mark. 1946- . Born in Bristol, England. Educated at the University of Oxford. Special Assistant, United Nations Emergency Relief Operation to Bangladesh. Served the United Nations, New York, in the Office of the Under-Secretary General and the Office of the Secretary General (Kurt Waldheim). Assistant Director, Office of the Commonwealth Secretary General (Sir Shridath Ramphal), 1977-83. Conservative Member of Parliament for Newport West, 1983-87, and Somerton and Frome, 1992-97. Appointed to the Foreign Affairs Select Committee in the government of Margaret Thatcher. Parliamentary Private Secretary to the Minister for Overseas Development and the Foreign and Commonwealth Secretary. Member of the Board, Commonwealth Development Corporation, 1988-92. Chair, Commonwealth Consortium for Education

Adoption and motivational factors for online grocery shopping in the UK

Following upon the results of previous qualitative research (Authors, 2005), the objective of this paper is to confirm the role of situational variables in the adoption process of online grocery shopping. Situational variables and life events in particular (e.g. having a baby, health problems) emerge as the trigger for starting online grocery shopping for two clusters. However, the adoption of e-grocery shopping seems to be re-evaluated frequently and consequently post-adoption evaluation appears crucial to the decision of whether to continue with or to drop internet grocery shopping

Black Holes with a Massive Dilaton

The modifications of dilaton black holes which result when the dilaton acquires a mass are investigated. We derive some general constraints on the number of horizons of the black hole and argue that if the product of the black hole charge $Q$ and the dilaton mass $m$ satisfies $Q m < O(1)$ then the black hole has only one horizon. We also argue that for $Q m > O(1)$ there may exist solutions with three horizons and we discuss the causal structure of such solutions. We also investigate the possible structures of extremal solutions and the related problem of two-dimensional dilaton gravity with a massive dilaton.Comment: 36 pages with 5 figures (as uuencoded compressed tar file) (revised version has one major change in bound on mass for extremal solution and minor typos fixed), harvma

Rapid and punctuated Late Holocene recession of Siling Co, central Tibet

This work was supported by a National Science Foundation grant from the Tectonics program (EAR-0911587) to E.K. and K.P.F. Additional support to E.W. was provided by grants from the Chinese Academy of Sciences (XDB03010500). X.S. also thanks the support from the Earth Observatory of Singapore, Nanyang Technological University through its funding from the National Research Foundation Singapore and the Singapore Ministry of Education under the Research Centers of Excellence initiative.Variations in the strength of the Asian monsoon during Holocene time are thought to have been associated with widespread changes in precipitation across much of Tibet. Local records of monsoon strength from cave deposits, ice cores, and lake sediments typically rely on proxy data that relate isotopic variations to changes in precipitation. Lake expansion and contraction in response to changing water balance are likewise inferred from sedimentologic, isotopic and paleobiologic proxies, but relatively few direct records of changes in lake volume from preserved shorelines exist. Here we utilize relict shoreline deposits and associated alluvial fan features around Siling Co, the largest lake in central Tibet, to reconstruct centennial-to-millennial-scale variations in lake area and volume over the Holocene. Mapping and surveying of lacustrine shorelines coupled with optically stimulated luminescence dating of associated deposits indicate protracted occupation of a highstand elevation from >8 ka to 4 ka, followed by rapid recession that was likely punctuated by several stillstands of centennial-scale duration. Calculation of the changes in lake surface area and past hydrologic indices of the Siling Co basin suggests the effective moisture during the early Holocene highstand was approximately three times greater than today. In contrast to other lakes in central and western Tibet, our results suggest that Siling Co did not begin to recede synchronously with decreasing solar insolation at ca. 9–8 ka. Rather, initial recession of Siling Co appears to correspond to a time period of enhanced aridity and weakened monsoon in both Africa and Asia at ca. 4.2 ka. Our results add to a growing body of literature that suggest a period of relatively severe aridity on the Tibetan Plateau at this time. We suggest that subsequent punctuated recession of Siling Co was punctuated by similar periods of abrupt climate change during the Late Holocene.Publisher PDFPeer reviewe