Living in Fear: The Dynamics of Extortion in Mexico’s Drug War

Why do drug trafficking organizations (DTOs) sometimes prey on the communities in which they operate but sometimes provide assistance to these communities? What explains their strategies of extortion and co-optation toward civil society? Using new survey data from Mexico, including list experiments to elicit responses about potentially illegal behavior, this article measures the prevalence of extortion and assistance among DTOs. In support of our theory, these data show that territorial contestation among rival organizations produces more extortion and, in contrast, DTOs provide more assistance when they have monopoly control over a turf. The article uncovers other factors that also shape DTOs’ strategies toward the population, including the degree of collaboration with the state, leadership stability and DTO organization, and the value and logistics of the local criminal enterprise

A dark energy multiverse

We present cosmic solutions corresponding to universes filled with dark and phantom energy, all having a negative cosmological constant. All such solutions contain infinite singularities, successively and equally distributed along time, which can be either big bang/crunchs or big rips singularities. Classicaly these solutions can be regarded as associated with multiverse scenarios, being those corresponding to phantom energy that may describe the current accelerating universe

Death and Liver Transplantation within Two Years of Onset of Drug-Induced Liver Injury

Drug-induced liver injury (DILI) is an important cause of death and indication for liver transplantation (fatality). The role of DILI in these fatalities ispoorly characterized particularly when fatalities occur > 26 weeks after DILI onset. We analyzed patients in the U.S. Drug-Induced Liver Injury Network prospective study having a fatal outcome within 2 years of onset. Each case was reviewed by 8 Network investigators and categorized as DILI having a primary, contributory or no role in the fatality. We subcategorized primary role cases as acute, chronic, acute-on-chronic or acute cholestatic liver failure. For contributory and no role cases, we assigned a primary cause of death. Among 1089 patients, 107 (9.8%) fatalities occurred within 2 years. DILI had a primary role in 68 (64%), a contributory role in 15 (14%) and no role in 22 (21%); 2 had insufficient data. Among primary role cases, 74% had acute, 13% chronic, 7% acute-on-chronic and 6% acute cholestatic failure. For the 15 contributory role cases, common causes of death included sepsis, malignancy and severe cutaneous reactions with multi-organ failure. For the 22 no role cases, malignancies accounted for most fatalities. Higher bilirubin, coagulopathy, leukocytosis and thrombocytopenia were independently associated with DILI fatalities. nR Hy's Law had a higher positive predictive value for overall fatality (14% vs. 10%) and stronger independent association with DILI fatalities within 26 weeks compared to the original version of Hy's Law (HR: 6.2, CI 3.4 – 11.1 vs. 2.2, CI 1.3-3.7). DILI leads directly or indirectly to fatality in 7.6% of cases; 40% of these have non-acute liver failure courses. nR Hy's Law better identifies risk for death compared to the original Hy's Law

PLANEACIÓN DIDÁCTICA GENERAL DE LA ASIGNATURA: LÓGICA

GUÍA DIDÁCTICA / PLANEACIÓN DIDÁCTICA (NMS

RENTABILIDAD DEL NOGAL PECANERO BAJO SISTEMAS DE PRODUCCIÓN DE MEDIANA TECNOLOGÃA EN DELICIAS, CHIHUAHUA

Pecans (Carya Illinoinensis [Wangenh] K. Koch) are a native food of North America and represent a high economic crop value in the north of Mexico, mainly in the state of Chihuahua, the biggest pecan nut producer in this country. The goal of this study was to evaluate the profitability of pecan orchards in the municipality of Delicias, Chihuahua. Some microeconomic and market information from 2008 were collected from pecan growers and specialists through the technique of Experts' Panel. Standard financial analysis and a Monte Carlo simulation model were used to evaluate the probabilities of risk for net cash income (NCI) and return on capital employed (RCE). The NCI obtained was $277,000 and RC 111.7%, indicating that pecan orchards show high profitability when is produced under medium-technology conditions in the municipality of Delicias, Chihuahua.Carya Illinoinensis, production costs, Monte Carlo simulation., Agribusiness,

Bulk cell density and Wnt/TGFbeta signalling regulate mesendodermal patterning of human pluripotent stem cells

In vitro differentiation of human pluripotent stem cells (hPSCs) recapitulates early aspects of human embryogenesis, but the underlying processes are poorly understood and controlled. Here we show that modulating the bulk cell density (BCD: cell number per culture volume) deterministically alters anteroposterior patterning of primitive streak (PS)-like priming. The BCD in conjunction with the chemical WNT pathway activator CHIR99021 results in distinct paracrine microenvironments codifying hPSCs towards definitive endoderm, precardiac or presomitic mesoderm within the first 24 h of differentiation, respectively. Global gene expression and secretome analysis reveals that TGFß superfamily members, antagonist of Nodal signalling LEFTY1 and CER1, are paracrine determinants restricting PS progression. These data result in a tangible model disclosing how hPSC-released factors deflect CHIR99021-induced lineage commitment over time. By demonstrating a decisive, functional role of the BCD, we show its utility as a method to control lineage-specific differentiation. Furthermore, these findings have profound consequences for inter-experimental comparability, reproducibility, bioprocess optimization and scale-up.DFG/REBIRTHDFG/EXC62/1DFG/ZW 64/4-1DFG/MA 2331/16-1BMBF/13N12606BMBF/StemBANCCEU H2020/66872