Sleep-related attentional bias for faces depicting tiredness in insomnia: evidence from an eye-tracking study

Study Objectives: To date, evidence of an attentional bias in insomnia has mostly been obtained through reaction time tasks, with a limited number of studies using eye tracking. Here, using an eye-tracking paradigm, this study sought to determine whether individuals with insomnia display an attentional bias for novel faces depicting tiredness. Methods: Individuals with insomnia (n = 20) and normal sleepers (n = 20) viewed a series of face pairs depicting neutral and tired expressions each for periods of 4000 milliseconds. Eye movements were recorded using eye tracking, and first fixation onset, first fixation duration, total fixation duration, and total gaze duration were examined for three interest regions (eyes, nose, mouth). Results: Significant group × face interactions for total fixation duration and total gaze duration indicated that, regardless of interest-region, participants with insomnia spent more time fixating on and observing tired faces relative to neutral faces when compared with normal sleepers. Additionally, significant group × face × interest-region interactions for total fixation duration and total gaze duration indicated that participants with insomnia spent more time observing the eye region of the tired faces than the eye region of the neutral faces when compared with normal sleepers. Conclusions: Individuals with insomnia display an attentional bias toward tired faces, more specifically for the eye region compared to normal sleepers. These findings contribute to our understanding of face perception in insomnia and provide more objective support for cognitive models of insomnia, suggesting that individuals with insomnia selectively attend to faces for tiredness cues

Sleep duration, sleep variability, and impairments of visual attention

Attentional networks are sensitive to sleep deprivation. However, variation in attentional performance as a function of normal sleep parameters is under-studied. We examined whether attentional performance is influenced by 1) individual differences in sleep duration; 2) sleep duration variability; and/or 3) their interaction. Fifty-seven healthy participants (61.4% female; mean age=32.37 years; SD=8.68) completed questionnaires, wore wrist actigraphy for one week, and subsequently completed the Attention Network Test. Sleep duration and sleep duration variability did not predict orienting score, executive control score or error rates. Sleep duration variability appeared to moderate the association between sleep duration with overall reaction time (β = -.34, t= -2.13, p=.04) and alerting scores (β= .43, t=2.94, p=.01), though further inspection of the data suggested that these were spurious findings. Time of testing was a significant predictor of alerting score (β=.35, t=2.96, p=.01), chronotype of orienting (β=.31, t=2.28, p=.03) and age of overall reaction time (β=.35, t=2.70, p=.01). Our results highlight the importance of examining the associations between variations in sleep-wake patterns and attentional networks in samples with greater variation in sleep, as well as the importance of rigorously teasing apart mechanisms of the sleep homeostat from those related to the circadian rhythm in studies examining cognition

Auditory, phonological and semantic factors in the recovery from Wernicke’s aphasia post stroke: predictive value and implications for rehabilitation

Background: Understanding the factors that influence language recovery in aphasia is important for improving prognosis and treatment. Chronic comprehension impairments Wernicke’s-type aphasia (WA) are associated with impairments in auditory and phonological processing, compounded by semantic and executive difficulties. This study investigated whether the recovery of auditory, phonological, semantic or executive factors underpins the recovery from WA comprehension impairments by charting changes in the neuropsychological profiles from the sub-acute to the chronic phase. Method: This study used a prospective, longitudinal, observational design. Twelve WA participants with superior temporal lobe lesions were recruited before 2 months post stroke onset (MPO). Language comprehension was measured alongside a neuropsychological profile of auditory, phonological and semantic processing alongside phonological short-term memory and nonverbal reasoning at three post stroke time points: 2.5, 5 and 9MPO. Results: Language comprehension displayed a strong and consistent recovery between 2.5 and 9MPO. Improvements were also seen for slow auditory temporal processing, phonological short-term memory, and semantic processing, but not for rapid auditory temporal, spectrotemporal and phonological processing. Despite their lack of improvement, rapid auditory temporal processing at 2.5MPO and phonological processing at 5MPO predicated comprehension outcomes at 9MPO. Conclusions: These results indicate that recovery of language comprehension in WA can be predicted from fixed auditory processing in the subacute stage. This suggests that speech comprehension recovery in WA results from reorganisation of the remaining language comprehension network to enable the residual speech signal to be processed more efficiently, rather than partial recovery of underlying auditory, phonological or semantic processing abilities

Associations of common breast cancer susceptibility alleles with risk of breast cancer subtypes in BRCA1 and BRCA2 mutation carriers

Peer reviewedPublisher PD

BRCA2 polymorphic stop codon K3326X and the risk of breast, prostate, and ovarian cancers

Background: The K3326X variant in BRCA2 (BRCA2*c.9976A>T; p.Lys3326*; rs11571833) has been found to be associated with small increased risks of breast cancer. However, it is not clear to what extent linkage disequilibrium with fully pathogenic mutations might account for this association. There is scant information about the effect of K3326X in other hormone-related cancers. Methods: Using weighted logistic regression, we analyzed data from the large iCOGS study including 76 637 cancer case patients and 83 796 control patients to estimate odds ratios (ORw) and 95% confidence intervals (CIs) for K3326X variant carriers in relation to breast, ovarian, and prostate cancer risks, with weights defined as probability of not having a pathogenic BRCA2 variant. Using Cox proportional hazards modeling, we also examined the associations of K3326X with breast and ovarian cancer risks among 7183 BRCA1 variant carriers. All statistical tests were two-sided. Results: The K3326X variant was associated with breast (ORw = 1.28, 95% CI = 1.17 to 1.40, P = 5.9x10- 6) and invasive ovarian cancer (ORw = 1.26, 95% CI = 1.10 to 1.43, P = 3.8x10-3). These associations were stronger for serous ovarian cancer and for estrogen receptor–negative breast cancer (ORw = 1.46, 95% CI = 1.2 to 1.70, P = 3.4x10-5 and ORw = 1.50, 95% CI = 1.28 to 1.76, P = 4.1x10-5, respectively). For BRCA1 mutation carriers, there was a statistically significant inverse association of the K3326X variant with risk of ovarian cancer (HR = 0.43, 95% CI = 0.22 to 0.84, P = .013) but no association with breast cancer. No association with prostate cancer was observed. Conclusions: Our study provides evidence that the K3326X variant is associated with risk of developing breast and ovarian cancers independent of other pathogenic variants in BRCA2. Further studies are needed to determine the biological mechanism of action responsible for these associations

“Violence and aggression although not acceptable will happen, can happen and does happen”: a study of staffs’ experience of violence in child and family services

Background: Since the 1980’s incidents of workplace violence have been recognised as a serious problem within social care. It has been found to be particularly rife within residential settings and children’s homes in particular have been found to be one of the most violence-prone settings. And yet, there is a lack of literature on the prevalence and psychosocial impact of workplace violence on staff in residential units for looked after and accommodated children (LAAC). Method: Given the limited literature on residential childcare workers a systematic review was conducted on research of violence towards social workers in child and family services to achieve a better understand of violence within child and family social care generally. An empirical study was also conducted with staff of Local Authority residential units within Central Scotland. The aim of the empirical study was to explore staffs’ experience of workplace violence perpetrated by LAAC in residential settings, using the qualitative methodology Interpretative Phenomenological Analysis (IPA). Results: The systematic review showed that studies were mostly of medium methodological quality; verbal aggression towards social workers in child and family services was common place; physical violence was comparatively rare; and that all forms of violence impacted on wellbeing and practice. The empirical study had similar findings, but also provided new insights into how staff cope with workplace violence, particularly in the context of young peoples’ life experiences. Conclusion: Violence perpetrated by LAAC in residential units appeared to be lessening and a move towards more behaviour management was aiding staff to better understand the roots of violence. This in turn was found to help staff cope better with the emotional impact of violence. Management need to be mindful of the impact violence has on staff and continue providing training programs to better equip staff to understand violence and support LAAC to manage their aggression

Decadal climate variability and predictability: challenges and opportunities

The study of Decadal Climate Variability (DCV) and Predictability is the interdisciplinary endeavor to characterize, understand, attribute, simulate, and predict the slow, multi-year variations of climate at global (e.g. the recent slowdown of global mean temperature rise in the early 2000s) and regional scales (e.g. decadal modulation of hurricane activity in the Atlantic, ongoing drought in California or in the Sahel in the 1970s-1980s, etc.). This study remains very challenging in spite of decades of research, extensive progress in climate system modeling and improvements in the availability and coverage of a wide variety of observations. Considerable obstacles in applying this knowledge to actual predictions remain. This short article is a succint review paper about DCV and predictability. Based on listed issues and priorities, it also proposes a unifying theme referred to as “drivers of teleconnectivity” as a backbone to address and structure the core DCV research challenge. This framework goes beyond a preoccupation with changes in the global mean temperature and directly addresses the regional impacts of external (natural and anthropogenic) climate forcing and internal climate interactions; it thus explicitly deals with the societal needs for region-specific climate information. Such a framework also enables the integration of efforts in a large international research community towards advancing the observation, characterization, understanding and prediction of DCV. Recommendations to make progress are provided as part of the contribution of the CLIVAR “DCVP Research Focus” group

Note of Association of Research Managers and Administrators REF Audit Compliance Meeting

No abstract available

Note of Association of Research Managers and Administrators REF Audit Compliance Meeting

No abstract available

Involvement of Sigma-1 Receptors in the Antidepressant-Like Effects of Dextromethorphan

Dextromethorphan is an antitussive with a high margin of safety that has been hypothesized to display rapid-acting antidepressant activity based on pharmacodynamic similarities to the N-methyl-D-aspartate (NMDA) receptor antagonist ketamine. In addition to binding to NMDA receptors, dextromethorphan binds to sigma-1 (s1) receptors, which are believed to be protein targets for a potential new class of antidepressant medications. The purpose of this study was to determine whether dextromethorphan elicits antidepressant-like effects and the involvement of s1 receptors in mediating its antidepressant-like actions. The antidepressant-like effects of dextromethorphan were assessed in male, Swiss Webster mice using the forced swim test. Next, s1 receptor antagonists (BD1063 and BD1047) were evaluated in conjunction with dextromethorphan to determine the involvement of s receptors in its antidepressant-like effects. Quinidine, a cytochrome P450 (CYP) 2D6 inhibitor, was also evaluated in conjunction with dextromethorphan to increase the bioavailability of dextromethorphan and reduce exposure to additional metabolites. Finally, saturation binding assays were performed to assess the manner in which dextromethorphan interacts at the s1 receptor. Our results revealed dextromethorphan displays antidepressant-like effects in the forced swim test that can be attenuated by pretreatment with s1 receptor antagonists, with BD1063 causing a shift to the right in the dextromethorphan dose response curve. Concomitant administration of quinidine potentiated the antidepressant-like effects of dextromethorphan. Saturation binding assays revealed that a Ki concentration of dextromethorphan reduces both the Kd and the Bmax of [3H](+)-pentazocine binding to s1 receptors. Taken together, these data suggest that dextromethorphan exerts some of its antidepressant actions through s1 receptors