Comparison of the influence of cyclosporine and tacrolimus on the pharmacokinetics of prednisolone in adult male kidney transplant recipients

Cyclosporine has been observed to precipitate cushingoid features in kidney transplant recipients already on prednisolone. Some pharmacokinetic studies have demonstrated increased prednisolone exposure in patients on cyclosporine therapy compared with azathioprine, whereas other studies have found no difference. The objective of this study was to determine whether cyclosporine impacts on prednisolone exposure as compared with tacrolimus

Rate and duration of hospitalisation for acute pulmonary embolism in the real-world clinical practice of different countries : Analysis from the RIETE registry

publishersversionPeer reviewe

Euclid preparation: LIX. Angular power spectra from discrete observations

In this paper we present the framework for measuring angular power spectra in the Euclid mission. The observables in galaxy surveys, such as galaxy clustering and cosmic shear, are not continuous fields, but discrete sets of data, obtained only at the positions of galaxies. We show how to compute the angular power spectra of such discrete data sets, without treating observations as maps of an underlying continuous field that is overlaid with a noise component. This formalism allows us to compute the exact theoretical expectations for our measured spectra, under a number of assumptions that we track explicitly. In particular, we obtain exact expressions for the additive biases (‘shot noise’) in angular galaxy clustering and cosmic shear. For efficient practical computations, we introduce a spin-weighted spherical convolution with a well-defined convolution theorem, which allows us to apply exact theoretical predictions to finite-resolution maps, including HEALPix. When validating our methodology, we find that our measurements are biased by less than 1% of their statistical uncertainty in simulations of Euclid’s first data release

<em>Euclid </em>preparation LXXIII. Spatially resolved stellar populations of local galaxies with <em>Euclid</em>: A proof of concept using synthetic images with the TNG50 simulation

\ua9 The Authors 2025.The European Space Agency’s Euclid mission will observe approximately 14 000 deg2 of the extragalactic sky and deliver high-quality imaging of a large number of galaxies. The depth and high spatial resolution of the data will enable a detailed analysis of the stellar population properties of local galaxies through spatially resolved spectral energy distribution (SED) fitting. In this study, we test our pipeline for spatially resolved SED fitting using synthetic images of Euclid, LSST, and GALEX generated from the TNG50 simulation using the SKIRT 3D radiative transfer code. Our pipeline uses functionalities in piXedfit for processing the simulated data cubes and carrying out SED fitting. We apply our pipeline to 25 simulated galaxies at z ∼ 0 to recover their resolved stellar population properties. For each galaxy, we produce three types of data cubes: GALEX + LSST + Euclid, LSST + Euclid, and Euclid-only. We performed the SED fitting tests with two stellar population synthesis (SPS) models in a Bayesian framework. Because the age, metallicity (Z), and dust attenuation estimates are biased when applying only classical formulations of flat priors (even with the combined GALEX + LSST + Euclid data), we examined the effects of additional physically motivated priors in the forms of mass-age and mass-metallicity relations, constructed using a combination of empirical and simulated data. Stellar-mass surface densities can be recovered well using any of the three data cubes, regardless of the SPS model and prior variations. The new priors then significantly improve the measurements of mass-weighted age and Z compared to results obtained without priors, but they may play an excessive role compared to the data in determining the outcome when no ultraviolet (UV) data is available. Compared to varying the spectral extent of the data cube or including and discarding the additional priors, replacing one SPS model family with the other has little effect on the results. The spatially resolved SED fitting method is powerful for mapping the stellar population properties of many galaxies with the current abundance of high-quality imaging data. Our study re-emphasizes the gain added by including multi-wavelength data from ancillary surveys and the roles of priors in Bayesian SED fitting. With the Euclid data alone, we will be able to generate complete and deep stellar mass maps of galaxies in the local Universe (z . 0.1), exploiting the telescope’s wide field, near-infrared sensitivity, and high spatial resolution

Assessment of Incurred Sample Reanalysis for Macromolecules to Evaluate Bioanalytical Method Robustness: Effects from Imprecision

Incurred sample reanalysis (ISR) is recommended by regulatory agencies to demonstrate reproducibility of validated methods and provide confidence that methods used in pharmacokinetic and toxicokinetic assessments give reproducible results. For macromolecules to pass ISR, regulatory recommendations require that two thirds of ISR samples be within 30% of the average of original and reanalyzed values. A modified Bland–Altman (mBA) analysis was used to evaluate whether total error (TE), the sum of precision and accuracy, was predictive of a method’s passing ISR and to identify potential contributing parameters for ISR success. Simulated studies determined minimum precision requirements for methods to have successful ISR and evaluated the relationship between precision and the probability of a method’s passing ISR acceptance criteria. The present analysis evaluated ISRs conducted for 37 studies involving ligand-binding assays (LBAs), with TEs ranging from 15% to 30%. An mBA approach was used to assess accuracy and precision of ISR, each with a threshold of 30%. All ISR studies met current regulatory criteria; using mBA, all studies met the accuracy threshold of 30% or less, but two studies (5%) failed to meet the 30% precision threshold. Simulation results showed that when an LBA has ≤15% imprecision, the ISR criteria for both the regulatory recommendation and mBA would be met in 99.9% of studies. Approximately 71% of samples are expected to be within 1.5 times the method imprecision. Therefore, precision appears to be a critical parameter in LBA reproducibility and may also be useful in identifying methods that have difficulty passing ISR