The Analysis of Coordinated Effects in EU Merger Control: Where Do We Stand after Sony/BMG and Impala?

The recent Impala Judgment by the CFI on the Sony/BMG Decision by the Commission represents the most important ruling on collective dominance since Airtours. We review both the Decision and the Judgment and derive implications for the institutional and substantive development of EU Merger Control. Firstly, Impala introduces an ambitious symmetric standard of proof for prohibition and clearance decisions by the Commission. While alleviating fears of an increasing number of false positives in the aftermath of Airtours, this entails the problem of how to deal with cases in which neither the existence, nor the absence of anticompetitive effects can be proven to the required standard. Secondly, the ongoing process of increasing the role of third parties in European Merger Control is fuelled. Thirdly, Impala has the potential to herald a comeback of coordinated effects analysis, further precising the conditions for establishing this kind of anticompetitive effect. Additionally, given the characteristics of the music industry, we criticise a lack of in-depth economic analysis of non-price competition issues, such as innovations and product diversity

Media Economics Theory and Practice Third Edition

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Allied Maritime Forces Transformation: Towards a Defence Planning Process That Includes Adaptable Warships

Warships have long service lives. During the life of a warship the types of operations that will be assigned to the ship will change (this happened for example at the end of the Cold War), the technology behind the installed systems will advance (e.g., radar performance and miniaturisation) and new technologies will emerge. New technologies are likely to require changes in the way operations are presently conducted (e.g., off-board systems for conducting mine countermeasures operations) and can deliver new operational capabilities to the ship (e.g., directed-energy weapon systems). For these reasons, warships can only maintain maximum operational relevance through-life if their operational capabilities can be augmented and adapted to meet changing user requirements. NATO nations and partners, and also their peer competitors, are designing and building more adaptable warships. A common characteristic of these ships is that mission essential systems can be added to and removed from the ship in a relatively short time period. Warship roles can thus be reconfigured. The future of this trend is transforming the NATO defence planning process so that the future structure of the allied maritime forces will include an appropriate mix of adaptable warships and up-to-date mission packages that can respond to constantly changing operational tasking. The naval architect is already aware that traditional warship design features must be re-worked to accommodate modular, in addition to—or even to replace—organic systems. This paper considers the transformation from the engineering and management of mission packages, their deployment and integration into new warship designs towards a new maritime defence planning philosophy and process.</jats:p

Regulation of miRNAs in human skeletal muscle following acute endurance exercise and short-term endurance training

The identification of microRNAs (miRNAs) has established new mechanisms that control skeletal muscle adaptation to exercise. The present study investigated the mRNA regulation of components of the miRNA biogenesis pathway (Drosha, Dicer and Exportin-5), muscle enriched miRNAs, (miR-1, -133a, -133b and -206), and several miRNAs dysregulated in muscle myopathies (miR-9, -23, -29, -31 and -181). Measurements were made in muscle biopsies from nine healthy untrained males at rest, 3 h following an acute bout of moderate-intensity endurance cycling and following 10 days of endurance training. Bioinformatics analysis was used to predict potential miRNA targets. In the 3 h period following the acute exercise bout, Drosha, Dicer and Exportin-5, as well as miR-1, -133a, -133-b and -181a were all increased. In contrast miR-9, -23a, -23b and -31 were decreased. Short-term training increased miR-1 and -29b, while miR-31 remained decreased. Negative correlations were observed between miR-9 and HDAC4 protein (r=-0.71; P= 0.04), miR-31 and HDAC4 protein (r =-0.87; P= 0.026) and miR-31 and NRF1 protein (r =-0.77; P= 0.01) 3 h following exercise. miR-31 binding to the HDAC4 and NRF1 3&prime; untranslated region (UTR) reduced luciferase reporter activity. Exercise rapidly and transiently regulates several miRNA species in muscle. Several of these miRNAs may be involved in the regulation of skeletal muscle regeneration, gene transcription and mitochondrial biogenesis. Identifying endurance exercise-mediated stress signals regulating skeletal muscle miRNAs, as well as validating their targets and regulatory pathways post exercise, will advance our understanding of their potential role/s in human healt