Exposicion economica al tipo de cambio de las sociedades anonimas chilenas

68 p.Las empresas chilenas, en este caso las sociedades anónimas abiertas, independientes de si tienen o no operaciones de comercio exterior tienen de una u otra forma dependencia de las variaciones en el tipo de cambio. Sin embargo existe una limitada gama de estudios relativos al tema en el ámbito local, y la evidencia disponible proviene en su mayoría de economías desarrolladas. En un reciente estudio, Chen et al. (2004) encuentra para Nueva Zelanda, economía pequeña y abierta, evidencia que indicaría que para este país los movimientos del tipo de cambio afectan el valor de las empresas transadas en bolsa. Basándose en la similitud con la economía Neo Zelandesa, nace la inquietud de replicar ese estudio en Chile. Esta investigación se justifica en el hecho de que a entender del autor no existen estudios relacionados con el tema en Chile, siendo relevante por al menos dos razones: la alta volatilidad que ha presentado el tipo de cambio desde que se adoptó la paridad flotante a mediados del año 1999 (ver apéndice 1) y por el poco desarrollo del mercado de instrumentos de cobertura. El propósito fundamental de esta memoria es determinar el nivel de exposición de las sociedades anónimas chilenas a variaciones en el tipo de cambio, y analizar algunos factores potenciales que influyen en la magnitud de esta exposición. Bajo la hipótesis de los mercados eficientes, el efecto del tipo de cambio debería ser reflejado en el precio de acciones. Las empresas que cumplen con los criterios de selección son 105, de las cuales alrededor del 40% presenta un nivel significativo de exposición al riesgo de cambio. El grado de exposición de las empresas en forma global es de carácter inverso, es decir, a medida que aumenta el valor del tipo de cambio, el valor de las empresas disminuye. Cabe destacar que la significancia económica es importante, esto se grafica en los montos que las empresas ganan o pierden de su capitalización bursátil ante una variación del dólar. A modo de ejemplo, la empresa menos afectada perdería aproximadamente 351 millones de pesos ante la subida de un 1% del valor de la divisa

Performance of prognostic index in severe Clostridium difficile-associated infection. Retrospective analysis in a university hospital

Indexación: ScieloIntroducción: Por consenso, la infección asociada a Clostridium difficile (IACD) grave es aquella que resulta en hospitalización en unidad de cuidados intensivos, colectomía o muerte dentro de 30 días. Múltiples índices pronósticos (IP) intentan predecir estos eventos adversos. Objetivo: evaluar el rendimiento de cuatro IP en la predicción de IACD grave. Metodología: pacientes hospitalizados ≥ 18 años con IACD fueron evaluados retrospectivamente. Se excluyeron pacientes con infección recurrente o cáncer hematológico. Se evaluaron cuatro IP: UPMC versión 1, Calgary versión 1, Hines VA y Calgary versión 2. Resultados: Siete de 81 pacientes (8,1%) presentaron una IACD grave. El valor predictor positivo (VPP) y valor predictor negativo (VPN) de los IP varió entre 20-75% y 91,3-95,7%, respectivamente. Sólo el índice de Hines VA tuvo un índice Kappa satisfactorio (0,74;IC 95% 0,46-1) con un VPP de 75% y un VPN de 95,7%. Sin embargo, por las variables incluidas en este IP, sólo pudo ser calculado en 32,6% de los pacientes. Conclusión: El índice de Hines VA presenta el mejor valor predictor y concordancia para descartar una IACD grave. Como otros IP, tiene la limitación de incluir variables difícilmente evaluables en todos los pacientes y tiende a sobreestimar un curso desfavorable.Introduction: By consensus severe, Clostridium difficile-associated infection (CDAI) is one that results in hospitalization in ICU, colectomy or death within 30 days. Multiple prognostic indices (IP) attempt to predict these adverse events. Objective: To evaluate the performance of 4 PI in predicting severe CDI. Methods: Hospitalized patients ≥ 18 years old with ICD were retrospectively evaluated. Patients with recurrent infection or hematological cancer were excluded. Four PI were evaluated: UPMC version 1, Calgary version 1, Hines VA and Calgary version 2. Results: Seven of 81 patients (8.1%) met the definition of severe CDI. Positive predicted value (PPV) and negative predicted value (NPV) of PI ranged from 20-75% and 91.3-95.7%, respectively. Only Hines VA index had a satisfactory Kappa index (0.74; 95% CI 0.41-1) with a PPV of 75% and NPV of 95,7%. However, because of the variables included, this PI could be calculated only in 32.6% of patients. Conclusion: Hines VA index has the best predicted value and agreement to rule out a severe CDI. Like others PI it has the limitation of including difficult variables to assess in all patients and tends to overestimate an unfavorable course.http://www.scielo.cl/pdf/rci/v31n6/art03.pd

Cardiovascular magnetic resonance findings in a pediatric population with isolated left ventricular non-compaction

<p>Abstract</p> <p>Background</p> <p>Isolated Left Ventricular Non-compaction (LVNC) is an uncommon disorder characterized by the presence of increased trabeculations and deep intertrabecular recesses. In adults, it has been found that Ejection Fraction (EF) decreases significantly as non-compaction severity increases. In children however, there are a few data describing the relation between anatomical characteristics of LVNC and ventricular function. We aimed to find correlations between morphological features and ventricular performance in children and young adolescents with LVNC using Cardiovascular Magnetic Resonance (CMR).</p> <p>Methods</p> <p>15 children with LVNC (10 males, mean age 9.7 y.o., range 0.6 - 17 y.o.), underwent a CMR scan. Different morphological measures such as the Compacted Myocardial Mass (CMM), Non-Compaction (NC) to the Compaction (C) distance ratio, Compacted Myocardial Area (CMA) and Non-Compacted Myocardial Area (NCMA), distribution of NC, and the assessment of ventricular wall motion abnormalities were performed to investigate correlations with ventricular performance. EF was considered normal over 53%.</p> <p>Results</p> <p>The distribution of non-compaction in children was similar to published adult data with a predilection for apical, mid-inferior and mid-lateral segments. Five patients had systolic dysfunction with decreased EF. The number of affected segments was the strongest predictor of systolic dysfunction, all five patients had greater than 9 affected segments. Basal segments were less commonly affected but they were affected only in these five severe cases.</p> <p>Conclusion</p> <p>The segmental pattern of involvement of non-compaction in children is similar to that seen in adults. Systolic dysfunction in children is closely related to the number of affected segments.</p

Proposal of an informed consent form to obtain audiovisual material from patients

An informed consent is mandatory to obtain any clinical audiovisual material from patients. Although there are some documents created for this purpose, there are some barriers for their application, such as the context in which they were created, the language and download availability. Aim: To create a proposal for an informed consent form (ICF) for the capture and different uses for audiovisual material from patients. Material and Methods: A bibliographic search was carried out to obtain different ICFs in Spanish and English, which were subjected to a process of translation, counter-translation and fragmentation. Subsequently, a panel of experts was formed by members of the Chilean Society of Plastic Surgery with extensive experience in social networks. Delphi methodology was applied to reach a consensus about the definitive content of the ICF based on the previously selected fragments. Results: ICFs available for download were identified. The panel was made up of seven Plastic Surgeons and two Delphi rounds were carried out through electronic surveys. At the end of the process, an ICF proposal was obtained for therapeutic, academic or scientific purposes and another for dissemination or education in the mass media. Conclusions: The proposed ICFs were liberated for their use among health care professionals in Chile, who could use them, provided that they are approved by the local healthcare ethics committees.Versión publicada - versión final del edito

MicroRNA profiling and bioinformatics target analysis in dorsal hippocampus of chronically stressed rats: Relevance to depression pathophysiology

Studies conducted in rodents subjected to chronic stress and some observations in humans after psychosocial stress, have allowed to establish a link between stress and the susceptibility to many complex diseases, including mood disorders. The studies in rodents have revealed that chronic exposure to stress negatively affects synaptic plasticity by triggering changes in the production of trophic factors, subunit levels of glutamate ionotropic receptors, neuron morphology, and neurogenesis in the adult hippocampus. These modifications may account for the impairment in learning and memory processes observed in chronically stressed animals. It is plausible then, that stress modifies the interplay between signal transduction cascades and gene expression regulation in the hippocampus, therefore leading to altered neuroplasticity and functioning of neural circuits. Considering that miRNAs play an important role in post-transcriptional-regulation of gene expression and participate in several hippocampus-dependent functions; we evaluated the consequences of chronic stress on the expression of miRNAs in dorsal (anterior) portion of the hippocampus, which participates in memory formation in rodents. Here, we show that male rats exposed to daily restraint stress (2.5 h/day) during 7 and 14 days display a differential profile of miRNA levels in dorsal hippocampus and remarkably, we found that some of these miRNAs belong to the miR-379-410 cluster. We confirmed a rise in miR-92a and miR-485 levels after 14 days of stress by qPCR, an effect that was not mimicked by chronic administration of corticosterone (14 days). Our in silico study identified the top-10 biological functions influenced by miR-92a, nine of which were shared with miR-485: Nervous system development and function, Tissue development, Behavior, Embryonic development, Organ development, Organismal development, Organismal survival, Tissue morphology, and Organ morphology. Furthermore, our in silico study provided a landscape of potential miRNA-92a and miR-485 targets, along with relevant canonical pathways related to axonal guidance signaling and cAMP signaling, which may influence the functioning of several neuroplastic substrates in dorsal hippocampus. Additionally, the combined effect of miR-92a and miR-485 on transcription factors, along with histone-modifying enzymes, may have a functional relevance by producing changes in gene regulatory networks that modify the neuroplastic capacity of the adult dorsal hippocampus under stress

CHANCES, The Chilean Cluster Galaxy Evolution Survey:selection and initial characterization of clusters and superclusters

CHANCES, the CHileAN Cluster galaxy Evolution Survey, will study the evolution of galaxies in and around ∼150 massive galaxy clusters, from the local universe out to z=0.45. CHANCES will use the new 4MOST Spectroscopic Survey Facility on the VISTA 4m telescope to obtain spectra for ∼500,000 galaxies with magnitudes rAB &lt; 20.5, providing comprehensive spectroscopic coverage of each cluster out to 5r200. Its wide and deep scope will trace massive and dwarf galaxies from the surrounding filaments and groups to the cores of galaxy clusters, enabling the study of galaxy pre-processing and the role of the evolving environment on galaxy evolution. In this paper we present and characterize the sample of clusters and superclusters to be targeted by CHANCES. We used literature catalogues based on X-ray emission and Sunyaev-Zel'dovich effect to define the cluster sample in a homogeneous way, with attention to cluster mass and redshift, as well as the availability of ancillary data. We calibrated literature mass estimates from various surveys against each other and provide an initial mass estimate for each cluster, which we used to define the radial extent of the 4MOST coverage. We also present an initial assessment of the structure surrounding these clusters based on the redMaPPer red-sequence algorithm as a preview of some of the science CHANCES will enable

International lower limb collaborative (INTELLECT) study: a multicentre, international retrospective audit of lower extremity open fractures

Trauma remains a major cause of mortality and disability across the world1, with a higher burden in developing nations2. Open lower extremity injuries are devastating events from a physical3, mental health4, and socioeconomic5 standpoint. The potential sequelae, including risk of chronic infection and amputation, can lead to delayed recovery and major disability6. This international study aimed to describe global disparities, timely intervention, guideline-directed care, and economic aspects of open lower limb injuries

Evolving trends in the management of acute appendicitis during COVID-19 waves. The ACIE appy II study

Background: In 2020, ACIE Appy study showed that COVID-19 pandemic heavily affected the management of patients with acute appendicitis (AA) worldwide, with an increased rate of non-operative management (NOM) strategies and a trend toward open surgery due to concern of virus transmission by laparoscopy and controversial recommendations on this issue. The aim of this study was to survey again the same group of surgeons to assess if any difference in management attitudes of AA had occurred in the later stages of the outbreak. Methods: From August 15 to September 30, 2021, an online questionnaire was sent to all 709 participants of the ACIE Appy study. The questionnaire included questions on personal protective equipment (PPE), local policies and screening for SARS-CoV-2 infection, NOM, surgical approach and disease presentations in 2021. The results were compared with the results from the previous study. Results: A total of 476 answers were collected (response rate 67.1%). Screening policies were significatively improved with most patients screened regardless of symptoms (89.5% vs. 37.4%) with PCR and antigenic test as the preferred test (74.1% vs. 26.3%). More patients tested positive before surgery and commercial systems were the preferred ones to filter smoke plumes during laparoscopy. Laparoscopic appendicectomy was the first option in the treatment of AA, with a declined use of NOM. Conclusion: Management of AA has improved in the last waves of pandemic. Increased evidence regarding SARS-COV-2 infection along with a timely healthcare systems response has been translated into tailored attitudes and a better care for patients with AA worldwide

CHANCES, the Chilean Cluster Galaxy Evolution Survey: Selection and initial characterisation of clusters and superclusters

CHANCES, the CHileAN Cluster galaxy Evolution Survey, will study the evolution of galaxies in and around 100 massive galaxy clusters from the local Universe out to z = 0.45, and two superclusters at z ∼ 0.05 that contain roughly 25 Abell clusters each. CHANCES will use the new 4MOST Spectroscopic Survey Facility on the VISTA 4m telescope to obtain spectra for ∼500,000 galaxies with magnitudes r AB < 20.4, providing comprehensive spectroscopic coverage of each cluster out to 5r 200. Its wide and deep scope will trace massive and dwarf galaxies from the surrounding filaments and groups to the cores of galaxy clusters. This will enable the study of galaxy preprocessing and of the role of the evolving environment on galaxy evolution. In this paper, we present and characterise the sample of clusters and superclusters to be targeted by CHANCES. We used literature catalogues based on X-ray emission and the Sunyaev-Zel'dovich effect to define the cluster sample in a homogeneous way, with attention to cluster mass and redshift, as well as the availability of ancillary data. We calibrated literature mass estimates from various surveys against each other and provide an initial mass estimate for each cluster, which we used to define the radial extent of the 4MOST coverage. We also present an initial assessment of the structure surrounding these clusters based on the redMaPPer red-sequence algorithm as a preview of some of the science CHANCES will enable