Synthesis of New Analogues of the Bengamides to encapsulate in magnetic nanoparticles

The development and identification of new antitumoral has become a research area of great interest and maximum priority due to secondary effects of current antitumoral and the appearance of tumours resistant to these agents. Marine sponges corresponding to the Jaspidae family have proved to be a prolific source of bioactive natural products. Among these, the Bengamides have showed an important biological profile, including antitumor, antibiotic and anthelmintic properties. Due to the interest of theses natural products, we describe a study directed towards the total synthesis of this class of compounds. Then we encapsulate Bengamides in temperature sensitive microgels with a magnetic core. Magnetic nanoparticles (Fe3O 4) were prepared by coprecipitation method and the surface was functionalized by acrylic acid. Polymer poly(N-isopropylacrylamide) (PNIPAM) were grown by free radical polymerization in presence of cross-liker and initiator.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tec

Thermorresponsive magnetic nanoparticles as target drug delivery for cancer treatment

In this research, temperature sensitive microgels with magnetic core for controlled release of 5-fluoruracil was synthesized. Magnetic nanoparticles (Fe3O4) were prepared by coprecipitation method and the surface was functionalized by acrylic acid. Polymer poly(N-isopropylacrylamide) (PNIPAM) were grown by free radical polymerization in presence of cross-liker and initiator. The size of the polymer was manipulated by changing the mole percent of the crosslinker and evaluated for their morphology (TEM), particle size, zeta potential, loading efficiency, drug content and drug release. Furthermore, microgels were tagged with FITC, a fluorochrome which could be applied for cell imaging. Cytotoxicity studies revealed that the microgels were not toxic. These complex nanoparticles (Fe3O4/pNIPAM/FITC/5-Fu) appear to be a great promise to be used in controlled drug delivery and tumor targeting.Universidad de Málaga. Campus de Excelencia Internacional Andalucía Tech

2M1155-79 (= T Cha B): A Low-mass, Wide-separation Companion to the Nearby, "Old" T Tauri Star T Cha

The early-K star T Cha, a member of the relatively nearby (D ~ 100 pc) epsilon Cha Association, is a relatively "old" (age ~7 Myr) T Tauri star that is still sporadically accreting from an orbiting disk whose inner regions are evidently now being cleared by a close, substellar companion. We report the identification, via analysis of proper motions, serendipitous X-ray imaging spectroscopy, and followup optical spectroscopy, of a new member of the epsilon Cha Association that is very likely a low-mass companion to T Cha at a projected separation of ~38 kAU. The combined X-ray and optical spectroscopy data indicate that the companion, T Cha B (= 2M1155-79), is a weak-lined T Tauri star (wTTS) of spectral type M3 and age ~<10 Myr. The serendipitous X-ray (XMM-Newton) observation of T Cha B, which targeted T Cha, also yields serendipitous detections of two background wTTS in the Chamaeleon cloud complex, including one newly discovered, low-mass member of the Cha cloud pre-MS population. T Cha becomes the third prominent example of a nearby, "old" yet still actively accreting, K-type pre-MS star/disk system (the others being TW Hya and V4046 Sgr) to feature a low-mass companion at very large (12-40 kAU) separation, suggesting that such wide-separation companions may affect the conditions and timescales for planet formation around solar-mass stars.Comment: 14 pages, 4 figures; to appear in The Astrophys. J. (Letters

Comparing the implementation of team approaches for improving diabetes care in community health centers

Background: Patient panel management and community-based care management may be viable strategies for community health centers to improve the quality of diabetes care for vulnerable patient populations. The objective of our study was to clarify implementation processes and experiences of integrating office-based medical assistant (MA) panel management and community health worker (CHW) community-based management into routine care for diabetic patients. Methods: Mixed methods study with interviews and surveys of clinicians and staff participating in a study comparing the effectiveness of MA and CHW health coaching for improving diabetes care. Participants included 24 key informants in five role categories and 249 clinicians and staff survey respondents from 14 participating practices. We conducted thematic analyses of key informant interview transcripts to clarify implementation processes and describe barriers to integrating the new roles into practice. We surveyed clinicians and staff to assess differences in practice culture among intervention and control groups. We triangulated findings to identify concordant and disparate results across data sources. Results: Implementation processes and experiences varied considerably among the practices implementing CHW and MA team-based approaches, resulting in differences in the organization of health coaching and self-management support activities. Importantly, CHW and MA responsibilities converged over time to focus on health coaching of diabetic patients. MA health coaches experienced difficulty in allocating dedicated time due to other MA responsibilities that often crowded out time for diabetic patient health coaching. Time constraints also limited the personal introduction of patients to health coaches by clinicians. Participants highlighted the importance of a supportive team climate and proactive leadership as important enablers for MAs and CHWs to implement their health coaching responsibilities and also promoted professional growth. Conclusion: Implementation of team-based strategies to improve diabetes care for vulnerable populations was diverse, however all practices converged in their foci on health coaching roles of CHWs and MAs. Our study suggests that a flexible approach to implementing health coaching is more important than fidelity to rigid models that do not allow for variable allocation of responsibilities across team members. Clinicians play an instrumental role in supporting health coaches to grow into their new patient care responsibilities

Intracluster stars in the Virgo cluster core

We have investigated the properties of the diffuse light in the Virgo cluster core region, based on the detection of intracluster planetary nebulae (PNe) in four fields. We eliminate the bias from misclassified faint continuum objects, using improved Monte Carlo simulations, and the contaminations by high redshift Ly$\alpha$ galaxies, using the Ly$\alpha$ luminosity function in blank fields. Recent spectroscopic observations confirm that our photometric PN samples are well-understood. We find that the diffuse stellar population in the Virgo core region is inhomogeneous on scales of 30'-90': there exist significant field-to-field variations in the number density of PNe and the inferred amount of intracluster light, with some empty fields, some fields dominated by extended Virgo galaxy halos, and some fields dominated by the true intracluster component. There is no clear trend with distance from M87. The mean surface luminosity density, its rms variation, and the mean surface brightness of diffuse light in our 4 fields are $\Sigma_B = 2.7 x 10^{6}$ L$_{B\odot}$ arcmin$^{-2}$, ${rms} = 2.1 \times 10^{6}$ L$_{B\odot}$ arcmin$^{-2}$, and $\bar{\mu}_{B}=29.0$ mag arcsec$^{-2}$ respectively. Our results indicate that the Virgo cluster is a dynamically young environment, and that the intracluster component is associated at least partially with local physical processes like galaxy interactions or harassment. We also argue, based on kinematic evidence, that the so-called 'over-luminous' PNe in the halo of M84 are dynamically associated with this galaxy, and must thus be brighter than and part of a different stellar population from the normal PN population in elliptical galaxies.Comment: 31 pages, 6 figure. In press on the Astronomical Journa

Aeronautical Metadata Profile based on Geographic International Standards

The aeronautical information plays an essential rolein air safety, chief objective of the aeronautical industry. Community policies and projects are being currently developed for the adequate management of a single European air space. To make this possible, an appropriate information management and a set of tools that allow sharing and exchanging this information, ensuring its interoperability and integrity, are necessary. This paper presents the development and implementation of a metadata profile for description of the aeronautical information based on international regulations and recommendations applied within the geographic scope. The elements taken into account for its development are described, as well as the implementation process and the results obtained

Conceptions sociales et politiques des territoires de mbyá guaraní: quelques éléments actuels pour votre considération

Este trabajo presenta algunos de los elementos relevantes que hacen a las nociones y prácticas territoriales mbyá actuales, intentando mostrar que los usos y formas de ocupación espacial atraviesan las definiciones hegemónicas del territorio. Se parte de un análisis etnográfico considerando los casos particulares de comunidades o tekoa mbyá ubicadas en los Departamentos de Caazapá e Itapúa, Paraguay, junto a las cuales hemos realizado proyectos de relevamiento territorial. En un contexto de transformación radical de los territorios a partir del avance de la agroindustria, los mbyá desenvuelven sus modos propios de vida social, económica, política y religiosa, también reconfigurando nociones y prácticas territoriales en relación a la sociedad envolvente. Los marcos de referencia mbyá son redefinidos constantemente en las relaciones que mantienen las comunidades entre sí y con los jurua (noindígenas), y los demás seres presentes en el entorno.Este artigo apresenta alguns dos elementos relevantes que formam as noções e práticas territoriais Mbyá atuais, procurando demostrar que os usos e formas de ocupação espacial estão atravessadas pelas definições hegemônicas do território. A partir de uma análise etnográfica, se considera os casos específicos de aldeias ou "tekoa" Mbyá localizadas nos departamentos de Caazapá e Itapúa (Paraguai), com quem realizamos projetos de levantamento territorial. No contexto da transformação radical dos territórios debido ao avanço da agroindústria, os Mbya desenvolvem seus modos de vida sociais, econômicos, políticos e religiosos, reconfigurando noções e práticas territoriais próprias em relação à sociedade envolvente. Os quadros de referência Mbyá são constantemente redefinidos nas relações que as comunidades têm entre eles, com os jurua (não indígenas) e os demais seres presentes no entorno.This work introduces some of the most relevant elements that make up the current territorial notions and practices of the mbyá, in an attempt to show that the uses and ways of land occupation exceed the hegemonic definitions of territory. The basis is an ethnographic analysis that considers individual cases of communities or tekoa mbyá, located in the Caazapá and Itapúa departments in Paraguay, with which we have conducted a territorial survey. In a context of radical transformation of the territories, given the agribusiness advancement, the mbyá develop their own ways of social, economical, political and religious life, also reconfiguring territorial notions and practices in relation to the surrounding society. The mbyá frameworks are constantly redefined in the relationships they hold among their communities and with the jurua (non-indigenous), and other beings in the environment.Cet article présente certains des éléments les plus pertinentes qui font aux notions et pratiques territoriales mbyá actuelles, en essayant de montrer que les habitudes et formes d´occupation spatiale passent par les définitions hégémoniques du territoire. On part d´une analyse ethnographique en considérant les cas particuliers des communautés ou tekoa mbyá situées dans les Départements de Caazapá et Itapúa, Paraguay, avec lesquelles on a réalisé des projets d´enquête territoriale. Dans un contexte de transformation radicale des territoires à partir du progrès de l´agro-industrie, les mbyá développent leurs propres modes de vie sociale, économique, politique et religieuse, en reconfigurant aussi des notions et pratiques territoriales en relation avec la société qui l´entoure. Les cadres de référence mbyá sont redéfinis constamment dans les rapport qui ont les communautés entre elles et avec les jurua (non indigènes), et avec les autres êtres présents dans l´environnement.Fil: Rodriguez Alcala Escobar, Carolina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de San Martín. Instituto de Altos Estudios Sociales; Argentin

Inversión pública para el desarrollo de infraestructura de transporte descentralizado Provias en la Región Cajamarca, 2020 - 2022

Sobre el producto de investigación doctoral en el cual el objetivo general fue analizar como la inversión pública favorece en el desarrollo de infraestructura del transporte descentralizado en la región de Cajamarca, 2020 – 2022; se consideró la metodología de tipo básica, con enfoque cualitativo y que condice con estudios básicos – dogmáticos. El instrumento y técnica expuesta es el conjunto de preguntas dentro de la entrevista, así como un análisis minucioso documentado, el instrumento utilizado está en función a la entrevista estructurado. Los entrevistados, E1, E2, E3, …y E10, coinciden que si debe existir una buena calificación al contratar un buen formulador de estudio durante las etapas de pre inversión, elaboración de expediente técnico y ejecución de la obra. Por lo que es, primordial asegurar la conclusión de la obra y el cumplimiento de los objetivos. Por ello, se concluyó que es vital, pues de esté depende la adecuada ejecución de la obra y es muy importante, para identificar correctamente la necesidad y la clave es que el formulador tenga experiencia y capacidad, para el desarrollo del expediente técnico, para que no haya contratiempos en la ejecución del proyecto, sumado la importancia que la elaboración del expediente técnico sea óptima ya que de este depende que la ejecución se realice en el tiempo programado, con las metas logradas y alternativas de solución que permita cerrar brechas. Asimismo, los hechos concretos mostrados en la tabla 4, 5, 6 y 7, se pudo discutir conforme al objetivo general planteado. Por lo tanto, existe mucho por mejorar dentro de las políticas públicas que beneficie el desarrollo de la infraestructura de transporte descentralizado y que permita cerrar las brechas económicas y de oportunidad social para todo

Isolation and analysis of phospholipids in dairy foods

The lipid fraction of milk is one of the most complex matrixes in foodstuffs due to the presence of a high number of moieties with different physical and chemical properties. Glycerolipids include glycerol and two fatty acids esterified in positions sn-1 and sn-2 with higher concentration of unsaturated fatty acids than in the triglyceride fraction of milk. Sphingolipids consist of a sphingoid base linked to a fatty acid across an amide bond.Their amphiphilic nature makes them suitable to be added into a variety of foods and recent investigations showthat phospholipids,mainly phosphatidylserine and sphingomyelin, can exert antimicrobial, antiviral, and anticancer activities as well as positive effects in Alzheimer’s disease, stress, and memory decline. Polar lipids can be found as natural constituents in the membranes of all living organisms with soybean and eggs as the principal industrial sources, yet they have low contents in phosphatidylserine and sphingomyelin. Animal products are rich sources of these compounds but since there are legal restrictions to avoid transmission of prions,milk and dairy products are gaining interest as alternative sources.This review summarizes the analysis of polar lipids in dairy products including sample preparation (extraction and fractionation/isolation) and analysis by GC or HPLC and the latest research works using ELSD, CAD, and MS detectors.info:eu-repo/semantics/publishedVersio

Financial Development and Economic Activity in Advanced and Developing Open Economies: Evidence from Panel Cointegration.

YesThis study considers the effects of financial development on output in a panel cointegration framework, focusing on the implications of trade and financial openness. Our analysis indicates that after controlling for cross-sectional dependence, the typical relationship between finance and output does not hold in the long run. This relationship, however, is re-established once we account for economic openness. While trade openness emerges as more important for developing countries, financial openness is more important for advanced economies. In the long run, causality runs from financial development to output in the advanced economies, while in developing economies causality is bidirectional. There is no short-run causality between financial development and output, however