Sequential star formation at the periphery of the HII regions Sh 217 and Sh 219

The HII regions Sh 217 and Sh 219 are textbook examples of a Stromgren sphere surrounded by an annular photodissociation region (PDR). The annular PDR is observed in both the 21 cm atomic hydrogen emission and the dust (PAH) emission near 8 micron (MSX Survey). An ultracompact radio continuum source is observed in the direction of the annular PDR, in both Sh 217 and Sh 219. JHKobservations show the presence of highly reddened stellar clusters (AV ~ 20 mag) in the directions of these radio sources. These clusters are also IRAS sources, of luminosities 22700 Lo for Sh 217 and 5900 Lo for Sh 219. Each cluster contains at least one luminous star with an IR colour excess; the one in the Sh 219 cluster shows H-alpha emission. The cluster associated with Sh 217 is almost spherical and contains luminous objects at its centre. The cluster associated with Sh 219 is elongated along the ionization front of this HII region. We argue that these are `second-generation clusters', which means that the physical conditions present in the PDRs, close to the ionization fronts, have favoured the formation of clusters containing massive objects. We discuss the physical mechanisms which may be at the origin of the observed triggered star formation.Comment: 12 pages, Late

Abacavir Alters the Transcription of Inflammatory Cytokines in Virologically Suppressed, HIV-Infected Women

Background: Abacavir (ABC) may be associated with a small, increased risk of myocardial infarction in HIV-infected adults, possibly related to cytokine-mediated inflammation. Methods: To evaluate the induction of inflammatory cytokine transcription by ABC, we used samples from women randomized to receive zidovudine/lamivudine/ABC (Trizivir) or lopinavir/ritonavir and zidovudine/lamividine (Kaletra/Combivir) from the third trimester through six-months postpartum for the prevention of mother-to-child transmission (PMTCT). Women were matched by CD4 count and baseline HIV RNA. All women attained viral suppression (<50 copies/ml) by the time of sampling. Results: Four cytokines showed a difference in expression between the treatment arms, all in a proinflammatory direction for the ABC arm: CD40LG 1.82-fold, (p=.027); IL-8 3.16-fold (p=.020); LTA 2.82-fold, (p=.008); and CCL5 −1.67-fold, (p=.035). At 12-months postpartum, 6-months after antiretroviral discontinuation, cytokine expression was similar by treatment arm. Conclusions: We conclude that ABC may upregulate proinflammatory cytokines at the transcriptional level in this population

The Internet of Things: the future or the end of mechatronics.

The advent and increasing implementation of user configured and user oriented systems structured around the use of cloud configured information and the Internet of Things is presenting a new range and class of challenges to the underlying concepts of integration and transfer of functionality around which mechatronics is structured. It is suggested that the ways in which system designers and educators in particular respond to and manage these changes and challenges is going to have a significant impact on the way in which both the Internet of Things and mechatronics develop over time. The paper places the relationship between the Internet of Things and mechatronics into perspective and considers the issues and challenges facing systems designers and implementers in relation to managing the dynamics of the changes required

The Fourteenth Data Release of the Sloan Digital Sky Survey: First Spectroscopic Data from the extended Baryon Oscillation Spectroscopic Survey and from the second phase of the Apache Point Observatory Galactic Evolution Experiment

The fourth generation of the Sloan Digital Sky Survey (SDSS-IV) has been in operation since July 2014. This paper describes the second data release from this phase, and the fourteenth from SDSS overall (making this, Data Release Fourteen or DR14). This release makes public data taken by SDSS-IV in its first two years of operation (July 2014-2016). Like all previous SDSS releases, DR14 is cumulative, including the most recent reductions and calibrations of all data taken by SDSS since the first phase began operations in 2000. New in DR14 is the first public release of data from the extended Baryon Oscillation Spectroscopic Survey (eBOSS); the first data from the second phase of the Apache Point Observatory (APO) Galactic Evolution Experiment (APOGEE-2), including stellar parameter estimates from an innovative data driven machine learning algorithm known as "The Cannon"; and almost twice as many data cubes from the Mapping Nearby Galaxies at APO (MaNGA) survey as were in the previous release (N = 2812 in total). This paper describes the location and format of the publicly available data from SDSS-IV surveys. We provide references to the important technical papers describing how these data have been taken (both targeting and observation details) and processed for scientific use. The SDSS website (www.sdss.org) has been updated for this release, and provides links to data downloads, as well as tutorials and examples of data use. SDSS-IV is planning to continue to collect astronomical data until 2020, and will be followed by SDSS-V.Comment: SDSS-IV collaboration alphabetical author data release paper. DR14 happened on 31st July 2017. 19 pages, 5 figures. Accepted by ApJS on 28th Nov 2017 (this is the "post-print" and "post-proofs" version; minor corrections only from v1, and most of errors found in proofs corrected

Oral abstracts 1: SpondyloarthropathiesO1. Detecting axial spondyloarthritis amongst primary care back pain referrals

Background: Inflammatory back pain (IBP) is an early feature of ankylosing spondylitis (AS) and its detection offers the prospect of early diagnosis of AS. However, since back pain is very common but only a very small minority of back pain sufferers have ASpA or AS, screening of back pain sufferers for AS is problematic. In early disease radiographs are often normal so that fulfilment of diagnostic criteria for AS is impossible though a diagnosis of axial SpA can be made if MRI evidence of sacroiliitis is present. This pilot study was designed to indicate whether a cost-effective pick up rate for ASpA/early AS could be achieved by identifying adults with IBP stratified on the basis of age. Methods: Patients aged between 18 and 45 years who were referred to a hospital physiotherapy service with back pain of more than 3 months duration were assessed for IBP. All were asked to complete a questionnaire based on the Berlin IBP criteria. Those who fulfilled IBP criteria were also asked to complete a second short questionnaire enquiring about SpA comorbidities, to have a blood test for HLA-B27 and CRP level and to undergo an MRI scan of the sacroiliac joints. This was a limited scan, using STIR, diffusion-weighted, T1 and T2 sequences of the sacroiliac joints to minimize time in the scanner and cost. The study was funded by a research grant from Abbott Laboratories Ltd. Results: 50 sequential patients agreed to participate in the study and completed the IBP questionnaire. Of these 27 (54%) fulfilled criteria for IBP. Of these, 2 patients reported a history of an SpA comorbidity - 1 psoriasis; 1 ulcerative colitis - and 3 reported a family history of an SpA comorbidity - 2 psoriasis; 1 Crohn's disease. 4 were HLA-B27 positive, though results were not available for 7. Two patients had marginally raised CRP levels (6, 10 -NR ≤ 5). 19 agreed to undergo MRI scanning of the sacroiliac joints and lumbar spine; 4 scans were abnormal, showing evidence of bilateral sacroiliitis on STIR sequences. In all cases the changes met ASAS criteria but were limited. Of these 4 patients 3 were HLA-B27 positive but none gave a personal or family history of an SpA-associated comorbidity and all had normal CRP levels. Conclusions: This was a pilot study yielding only limited conclusions. However, it is clear that: Screening of patients referred for physiotherapy for IBP is straightforward, inexpensive and quick. It appears that IBP is more prevalent in young adults than overall population data suggest so that targeting this population may be efficient. IBP questionnaires could be administered routinely during a physiotherapy assessment. HLA-B27 testing in this group of patients with IBP is a suitable screening tool. The sacroiliac joint changes identified were mild and their prognostic significance is not yet clear so that the value of early screening needs further evaluation. Disclosure statement: C.H. received research funding for this study from Abbott. A.K. received research funding for this study, and speaker and consultancy fees, from Abbott. All other authors have declared no conflicts of interes

High Temperature Superconducting Magnets with Active Control for Attraction Levitation Transport Applications

A research program, involving 3 British universities, directed at quantifying the controllability of High Temperature Superconducting (HTS) magnets for use in attraction levitation transport systems will be described. The work includes measurement of loss mechanisms for iron cored HTS magnets which need to produce a flux density of approx. 1 tesla in the airgap between the magnet poles and a ferromagnetic rail. This flux density needs to be maintained and this is done by introducing small variations of the magnet current using a feedback loop, at frequencies up to 10 Hz to compensate for load changes, track variation etc. The test magnet assemblies constructed so far will be described and the studies and modelling of designs for a practical levitation demonstrator (using commercially obtained HTS tape) will be discussed with particular emphasis on how the field distribution and its components, e.g., the component vector normal to the broad face of the tape, can radically affect design philosophy compared to the classical electrical engineering approach. Although specifically aimed at levitation transport the controllability data obtained have implications for a much wider range of applications

Sloan Digital Sky Survey IV: mapping the Milky Way, nearby galaxies, and the distant universe

We describe the Sloan Digital Sky Survey IV (SDSS-IV), a project encompassing three major spectroscopic programs. The Apache Point Observatory Galactic Evolution Experiment 2 (APOGEE-2) is observing hundreds of thousands of Milky Way stars at high resolution and high signal-to-noise ratios in the near-infrared. The Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) survey is obtaining spatially resolved spectroscopy for thousands of nearby galaxies (median ). The extended Baryon Oscillation Spectroscopic Survey (eBOSS) is mapping the galaxy, quasar, and neutral gas distributions between and 3.5 to constrain cosmology using baryon acoustic oscillations, redshift space distortions, and the shape of the power spectrum. Within eBOSS, we are conducting two major subprograms: the SPectroscopic IDentification of eROSITA Sources (SPIDERS), investigating X-ray AGNs and galaxies in X-ray clusters, and the Time Domain Spectroscopic Survey (TDSS), obtaining spectra of variable sources. All programs use the 2.5 m Sloan Foundation Telescope at the Apache Point Observatory; observations there began in Summer 2014. APOGEE-2 also operates a second near-infrared spectrograph at the 2.5 m du Pont Telescope at Las Campanas Observatory, with observations beginning in early 2017. Observations at both facilities are scheduled to continue through 2020. In keeping with previous SDSS policy, SDSS-IV provides regularly scheduled public data releases; the first one, Data Release 13, was made available in 2016 July

The nature of nursing practice in rural and remote Canada

© Canadian Nurses Association. Reproduced with permission. Further reproduction is prohibitedThese approaches complement one another while adding to our overall understanding of rural nursing practice. For example, the RNDB had not previously been analysed with rural nurses in mind. The demographic profile of rural RNs was generated for the first time for Canada as a whole and for the individual provinces and territories.(18) The documentary analysis takes a critical view of the policy context within which rural nurses practise.(19) The national survey has collected an abundance of information about rural nurses' work, quality of work life and degree of work satisfaction. And the experiences that nurses relate in the narrative approach bring to life the challenges and rewards of working in a variety of rural settings. A national survey of RNs working in rural and remote areas has been completed using a mailed questionnaire and followup based on Dillman's tailored design method.(29) The 3,933 eligible respondents represent all provinces and territories and an overall response rate of 68 per cent after correcting for duplicate registrations, address problems, and ineligibility (e.g., living rural, working urban). Sampling was done in collaboration with the professional nursing associations of each province and territory, using the databases of all RNs with active registration, while maintaining anonymity and confidentiality. The sampling strategy was twofold. First, a stratified random sample was selected from RNs with rural addresses(30) in each of the 10 provinces. Second, the questionnaire was mailed to the total population of Canadian RNs who indicated on their registration forms that their primary workplace was a nursing station or outpost setting and to all RNs registered in the territories (as an attempt to capture "remote" areas). Based on a total population of 229,813 RNs in Canada,(31) with stratification by province and assuming that the ratio of rural/urban nurses was similar to the rural/urban population proportions in the provinces,(32) we determined that 3,500 rural nurses would provide estimates that are statistically significant (p <.05) nationally, with a 90 per cent confidence level provincially. Rural nurses have many reasons to celebrate: they provide care to individuals and families of all ages, for a variety of conditions, in a range of rural and remote settings. Although they work in environments that are primarily governed by urban-centric policies and in workplaces where the quality of work life is often limited, the nurses reveal their passion and dedication to their communities and to practising in rural and remote areas through their stories and their survey comments. The nature of rural and remote nursing is deceiving; its complexity is seen during the nurses' interactions, first as community members and then as professionals. Rural nurses are often charting new courses in their communities and workplaces. Muriel Strode said, "Do not follow where the path may lead. Go instead where there is no path and leave a trail."(33) Discovering the nature of nursing practice in rural and remote Canada through this national study is the first step on such a path, and hopefully the first of many trails.Ye

Sloan Digital Sky Survey IV: Mapping the Milky Way, Nearby Galaxies, and the Distant Universe

We describe the Sloan Digital Sky Survey IV (SDSS-IV), a project encompassing three major spectroscopic programs. The Apache Point Observatory Galactic Evolution Experiment 2 (APOGEE-2) is observing hundreds of thousands of Milky Way stars at high resolution and high signal-to-noise ratios in the near-infrared. The Mapping Nearby Galaxies at Apache Point Observatory (MaNGA) survey is obtaining spatially resolved spectroscopy for thousands of nearby galaxies (median $z\sim 0.03$). The extended Baryon Oscillation Spectroscopic Survey (eBOSS) is mapping the galaxy, quasar, and neutral gas distributions between $z\sim 0.6$ and 3.5 to constrain cosmology using baryon acoustic oscillations, redshift space distortions, and the shape of the power spectrum. Within eBOSS, we are conducting two major subprograms: the SPectroscopic IDentification of eROSITA Sources (SPIDERS), investigating X-ray AGNs and galaxies in X-ray clusters, and the Time Domain Spectroscopic Survey (TDSS), obtaining spectra of variable sources. All programs use the 2.5 m Sloan Foundation Telescope at the Apache Point Observatory; observations there began in Summer 2014. APOGEE-2 also operates a second near-infrared spectrograph at the 2.5 m du Pont Telescope at Las Campanas Observatory, with observations beginning in early 2017. Observations at both facilities are scheduled to continue through 2020. In keeping with previous SDSS policy, SDSS-IV provides regularly scheduled public data releases; the first one, Data Release 13, was made available in 2016 July