Differential rates of perinatal maturation of human primary and nonprimary auditory cortex

Abstract Primary and nonprimary cerebral cortex mature along different timescales; however, the differences between the rates of maturation of primary and nonprimary cortex are unclear. Cortical maturation can be measured through changes in tissue microstructure detectable by diffusion magnetic resonance imaging (MRI). In this study, diffusion tensor imaging (DTI) was used to characterize the maturation of Heschl’s gyrus (HG), which contains both primary auditory cortex (pAC) and nonprimary auditory cortex (nAC), in 90 preterm infants between 26 and 42 weeks postmenstrual age (PMA). The preterm infants were in different acoustical environments during their hospitalization: 46 in open ward beds and 44 in single rooms. A control group consisted of 15 term-born infants. Diffusion parameters revealed that (1) changes in cortical microstructure that accompany cortical maturation had largely already occurred in pAC by 28 weeks PMA, and (2) rapid changes were taking place in nAC between 26 and 42 weeks PMA. At term equivalent PMA, diffusion parameters for auditory cortex were different between preterm infants and term control infants, reflecting either delayed maturation or injury. No effect of room type was observed. For the preterm group, disturbed maturation of nonprimary (but not primary) auditory cortex was associated with poorer language performance at age two years

Developments in an HF Nowcasting Model for Trans-Polar Airline Routes

HF communications can be difficult in the polar regions since they are strongly influenced by space weather events. Airline communications within the polar regions rely on HF communications and improved nowcasting and forecasting techniques in support of this are now required. Previous work has demonstrated that ray tracing through a realistic, historical ionosphere provides signal coverage in good agreement with measurements. This paper presents an approach to providing a real-time ionospheric model by assimilating TEC measurements and validates it against observations from ionosondes

MR diffusion changes in the perimeter of the lateral ventricles demonstrate periventricular injury in post-hemorrhagic hydrocephalus of prematurity

OBJECTIVES: Injury to the preterm lateral ventricular perimeter (LVP), which contains the neural stem cells responsible for brain development, may contribute to the neurological sequelae of intraventricular hemorrhage (IVH) and post-hemorrhagic hydrocephalus of prematurity (PHH). This study utilizes diffusion MRI (dMRI) to characterize the microstructural effects of IVH/PHH on the LVP and segmented frontal-occipital horn perimeters (FOHP). STUDY DESIGN: Prospective study of 56 full-term infants, 72 very preterm infants without brain injury (VPT), 17 VPT infants with high-grade IVH without hydrocephalus (HG-IVH), and 13 VPT infants with PHH who underwent dMRI at term equivalent. LVP and FOHP dMRI measures and ventricular size-dMRI correlations were assessed. RESULTS: In the LVP, PHH had consistently lower FA and higher MD and RD than FT and VPT (p\u3c.050). However, while PHH FA was lower, and PHH RD was higher than their respective HG-IVH measures (p\u3c.050), the MD and AD values did not differ. In the FOHP, PHH infants had lower FA and higher RD than FT and VPT (p\u3c.010), and a lower FA than the HG-IVH group (p\u3c.001). While the magnitude of AD in both the LVP and FOHP were consistently less in the PHH group on pairwise comparisons to the other groups, the differences were not significant (p\u3e.050). Ventricular size correlated negatively with FA, and positively with MD and RD (p\u3c.001) in both the LVP and FOHP. In the PHH group, FA was lower in the FOHP than in the LVP, which was contrary to the observed findings in the healthy infants (p\u3c.001). Nevertheless, there were no regional differences in AD, MD, and RD in the PHH group. CONCLUSION: HG-IVH and PHH results in aberrant LVP/FOHP microstructure, with prominent abnormalities among the PHH group, most notably in the FOHP. Larger ventricular size was associated with greater magnitude of abnormality. LVP/FOHP dMRI measures may provide valuable biomarkers for future studies directed at improving the management and neurological outcomes of IVH/PHH

Progress towards a propagation prediction service for HF communications with aircraft on trans-polar routes

Commercial airlines began operations over polar routes in 1999 with a small number of proving flights. By 2014 the number had increased to in excess of 12,000 flights per year, and further increases are expected. For safe operations, the aircraft have to be able to communicate with air traffic control centres at all times. This is achieved by VHF links whilst within range of the widespread network of ground stations, and is by HF radio in remote areas such as the Polar regions, the North Atlantic and Pacific where VHF ground infrastructure does not exist. Furthermore, the Russian side of the pole only has HF capability. Researchers at the University of Leicester and at Lancaster University have developed various models (outlined below) that can be employed in HF radio propagation predictions. It is anticipated that these models will form the basis of an HF forecasting and nowcasting service for the airline industry. Propagation coverage predictions make use of numerical ray tracing to estimate the ray paths through a model ionosphere. Initially, a background ionospheric model is produced, which is then perturbed to include the various ionospheric features prevalent at high latitudes (in particular patches, arcs, auroral zone irregularities and the mid-latitude trough) that significantly affect the propagation of the radio signals. The approach that we are currently adopting is to start with the IRI and to perturb this based on measurements made near to the time and area of interest to form the basis of the background ionospheric model. This is then further perturbed to include features such as the convecting patches, the parameters of which may also be informed by measurements. A significant problem is the high variability of the high latitude ionosphere, and the relative scarcity of real-time measurements over the region. Real time measurements that we will use as the basis for perturbing the IRI include ionosonde soundings from, e.g. the GIRO database, and TEC measurements from the IGS network. Real-time modelling of HF radiowave absorption in the D-region ionosphere is also included. The geostationary GOES satellites provide real-time information on X-ray flux (causing shortwave fadeout during solar flares) and the flux of precipitating energetic protons which correlates strongly with Polar Cap Absorption (PCA). Real-time solar wind and interplanetary magnetic field measurements from the ACE or DSCOVR spacecraft provide geomagnetic index estimates used to model the location of both auroral absorption (on a probabilistic basis) and the proton rigidity cutoff boundary that defines the latitudinal extent of PCA during solar proton events (SPE). Empirical climatological models have been uniquely adapted to assimilate recent measurements of cosmic noise absorption (at 30 MHz) from a large array of riometers in Canada and Scandinavia. The model parameters are continuously optimised and updated to account for regional and temporal variations in ionospheric composition (and hence HF absorption rate (dB/km)) that can change significantly during the course of an SPE, for example. Real-time optimisation during SPE can also improve estimates of the proton rigidity cutoff and improve the modelled ionospheric response function absorption vs. zenith angle) at twilight

Developments in HF Propagation Predictions to Support Communications with Aircraft on Trans-polar Routes

Commercial airlines began operations over polar routes in 1999 with a small number of proving flights. By 2014 the number had increased to in excess of 12,000 flights per year, and further increases are expected. For safe operations, the aircraft have to be able to communicate with air traffic control centres at all times. This is achieved by VHF links whilst within range of the widespread network of ground stations, and by HF radio in remote areas such as the Polar regions, the North Atlantic and Pacific where VHF ground infrastructure does not exist. Furthermore, the Russian side of the pole only has HF capability. This has created a demand for improved HF nowcasting and forecasting procedures to support the polar operations, which are the subject of this paper

Laevicaudata catalogus (Crustacea: Branchiopoda):an overview of diversity and terminology

The Laevicaudata (smooth clam shrimp) are a small group of freshwater bivalved branchiopod crustaceans in need of taxonomic revision. Here the extant Laevicaudata are defined and diagnosed according to modern standards, and synapomorphies are listed, discussed, and illustrated. A catalogue of the Laevicaudata is presented with synonyms and some taxa are partially revised. One hundred and three recent laevicaudatan taxa are presented, of which 39 are considered valid species. Chresonyms are provided for taxa redescribed according to modern standards. Furthermore we designate a neotype for Lynceus brachyurus Müller, 1776. This species catalogue will provide a basis for further taxonomic revision and phylogenetic work within the Laevicaudata

Branchinecta hiberna, a new species of fairy shrimp (Crustacea: Anostraca) from western North America

This is the published version. Copyright Brigham Young University, Monte L Bean Life Science MuseauBranchinecta hiberna, a new species of fairy shrimp, is described from temporary pools in the Great Basin region of south central Oregon, northeastern California, and adjacent Nevada. The new species shares several characters with Branchinecta cornigera Lynch, 1958: males bear a similar large patch of small spines on the basal segment of antenna 2, and females bear the similar robust antenna 2 with medial spur, brood pouch shape, and resting egg (cyst) morphology. The new species differs from B. cornigera in the shape of the distal segment of antenna 2 and the number and size of spines on the paired penis warts of males, and in the thoracic spine pattern and lack of dorsal cephalic projections in females. Observations on behavior and ecology of B. hiberna are discussed

An allometric scaling relationship in the brain of preterm infants

Allometry has been used to demonstrate a power–law scaling relationship in the brain of premature born infants. Forty-nine preterm infants underwent neonatal MRI scans and neurodevelopmental testing at age 2. Measures of cortical surface area and total cerebral volume demonstrated a power–law scaling relationship (α = 1.27). No associations were identified between these measures and investigated clinical variables. Term equivalent cortical surface area and total cerebral volume measures and scaling exponents were not related to outcome. These findings confirm a previously reported allometric scaling relationship in the preterm brain, and suggest that scaling is not a sensitive indicator of aberrant cortical maturation