JAVA synchronized collaborative multimedia toolkit: A collaborative communication tool

In this project a collaboration multimedia toolkit, JSCMT (Java Synchronized Collaborative Multimedia Toolkit) was developed which is intended to connect a group of people located in different geographical locations who are working on the same project

REV-ERBα influences the stability and nuclear localization of the glucocorticoid receptor

REV-ERBα (encoded by Nr1d1) is a nuclear receptor that is part of the circadian clock mechanism and regulates metabolism and inflammatory processes. The glucocorticoid receptor (GR, encoded by Nr3c1) influences similar processes, but is not part of the circadian clock, although glucocorticoid signaling affects resetting of the circadian clock in peripheral tissues. Because of their similar impact on physiological processes, we studied the interplay between these two nuclear receptors. We found that REV- ERBα binds to the C-terminal portion and GR to the N-terminal portion of HSP90α and HSP90β, a chaperone responsible for the activation of proteins to ensure survival of a cell. The presence of REV-ERBα influences the stability and nuclear localization of GR by an unknown mechanism, thereby affecting expression of GR target genes, such as IκBα (Nfkbia) and alcohol dehydrogenase 1 (Adh1). Our findings highlight an important interplay between two nuclear receptors that influence the transcriptional potential of each other. This indicates that the transcriptional landscape is strongly dependent on dynamic processes at the protein level

VGLUT1 binding to endophilin or intersectin1 and dynamin phosphorylation in a diurnal context

Glutamate is concentrated into synaptic vesicles (SV) by the vesicular glutamate transporters (VGLUT) 1 and 2. VGLUTs also harbor a Na+/Pi-transport activity when residing at the plasma membrane. Here we aimed to identify whether the diurnal switches of VGLUT1 parallels interactions with or modification of endocytic proteins.VGLUT1 and dynamin bind to SH3 domains of either endophilin (Enph) or intersectin 1 (ITSN1) harboring one or five SH3 domains A–E, respectively. We followed diurnal variations by pull down experiments using SH3 fusion protein and brains from mice entrained in a strict 24-h light–dark cycle (12-h light Zeitgeber (ZT) 0, 6; 12-h dark ZT 12 and 18). In pull downs with EnphSH3 interaction with VGLUT1 is high during the resting light and reduced during the active dark period while dynamin binding does not vary. This diurnal light/dark pattern depends on a functional period 2 gene and changes when animals are kept in complete darkness. Pull downs using ITSN1SH3 A reveal diurnally varying binding of VGLUT1 with slightly reduced VGLUT1/dynamin ratios at the beginning of the light (ZT 0) or the dark (ZT 12) period. Phosphorylation increases binding of VGLUT1 but not of dynamin to EnphSH3. In contrast binding of dynamin to ITSN1SH3 A decreases under phosphorylating conditions with no changes in VGLUT1 binding. Phosphorylation of dynamin at Ser 774 is high at ZT 6 and ZT 18 when more VGLUT1 is at the plasma membrane but low at ZT 0 and ZT 12 the diurnal peaks of VGLUT1 endocytosis. In conclusion the diurnally varying endocytosis of VGLUT1 involves differential interactions with the SH3 domains of Enph and ITSN1 and correlates with the de-phosphorylation of dynamin1

Design And Analysis Of Hanger Irrigation System

This study aimed to evaluate the effectiveness of a newly designed hanger irrigation system in providing consistent water supply for agriculture. Irrigation is a vital component of agriculture, and efforts have been made to increase the irrigated area through surface irrigation projects and groundwater resources. Agriculture plays a critical role in India's economic development, as around 70% of the population relies on it for their livelihoods and essential needs. However, the growing population has led to water scarcity, which poses a significant challenge to the farming sector. Therefore, there is a need to discover alternative irrigation systems that are durable and affordable. To minimize labor costs and ensure uniform water usage, the hanger irrigation system was designed using SolidWorks software, and Finite Element Analysis was employed to enhance vibrational sustainability and reduce deformation in the model. The structure was built using structural steel and bamboo fiber as materials, and vibration analysis was conducted with the ANSYS 19 software to ensure stability. Static analysis was also performed using different materials to improve the system's load-bearing capacity, and cost comparisons were made between bamboo and steel models. The results of the modal and static analyses of different materials were discussed to arrive at a conclusion.Overall, the study highlights the importance of effective water management during irrigation to achieve maximum crop productivity and meet the country's food production goals. The hanger irrigation system has the potential to provide a consistent water supply while minimizing labor costs, making it a viable alternative irrigation system for agriculture

RFID Based Smart Shopping Trolley with PCB Design

Shopping is captivating and addictive, but standing in never-ending billing queues is a tiring process. Even though various online shopping platforms are growing, retail shopping has never stepped back. To ease the shopping process and eliminate lengthy billing queues, a new product has to be introduced with the appropriate use of technology. This paper summarizes a Radio Frequency Identification based smart shopping trolley that provides automatic billing and customer satisfaction. The RFID tags on the products are read by the reader present on the shopping cart. The display screen present in the cart provides the cost information and gives the final billing amount. This is then sent to the cashier`s database using Wi-Fi module and hence saves the customer's time. This entire model is designed on the PCB and simulated

Interns perception towards pharmacology during clinical postings at RIMS, Raichur, India

Background: Every medical graduate must have the intention to prescribe rationally. It is pharmacology which teaches rational of prescribing of drug in undergraduate medical course. Therefore, many eminent medical educationists believe that pharmacology is the most essential part of the medical curriculum. Medical graduates join as interns in their respective teaching hospital immediately after graduation. Although interns work is usually under the supervision of a senior consultant but there are occasions, when they need to make their own decision. Internship is the intermediate period between under-graduation and general practice. The dexterity of health professional relies upon prescribing practices. Clinical pharmacology and therapeutics (CPT) is a crucial discipline for interns to acquire safe and rational prescription of drugs. This study was conducted with the intention to provide some light about the knowledge of pharmacology among the interns in RIMS Hospital Raichur, Karnataka.Methods: The study was done on interns of RIMS, Raichur. It was a descriptive questionnaire-based prospective study. A structured questionnaire modified from the work of Oshikoya et al, was used in the study which included four major categories namely basic demographic information, undergraduate CPT teaching, experience of adverse drug reaction (ADR) and any deficiency in the under-graduate CPT teaching.Results: Out of these 107 participants 54 (42%) rated pharmacology knowledge is good, while another 53(40%) had average understanding. As high as 80% (85) intern population feel that undergraduate training has prepared them to prescribe safely. 45 (41%) interns have already observed cases of adverse drug reactions in their short active clinical life.Conclusions: The present study has identified that pharmacology and therapeutics course curriculum is not enough to produce safe prescribers

RFID Based Smart Shopping Trolley with PCB Design

Shopping is captivating and addictive, but standing in never-ending billing queues is a tiring process. Even though various online shopping platforms are growing, retail shopping has never stepped back. To ease the shopping process and eliminate lengthy billing queues, a new product has to be introduced with the appropriate use of technology. This paper summarizes a Radio Frequency Identification-based smart shopping trolley that provides automatic billing and customer satisfaction. The RFID tags on the products are read by the reader present on the shopping cart. The display screen present in the cart provides the cost information and gives the final billing amount. This is then sent to the cashier`s database using a Wi-Fi module and hence saves the customer's time. This entire model is designed on the PCB and simulated

Scientific perspectives on Guillain-Barre Syndrome (GBS): A comprehensive review for sentience after early 2025 GBS outbreak in an Indian state

Background: Guillain-Barré Syndrome (GBS) is an acute, self-limiting, and rare neurological disorder wherein the body's immune system mistakenly attacks the peripheral nervous system (PNS). A report, published in February 2025 by the Indian newspaper ‘The Times of India’, highlighted a significant outbreak of GBS in the Indian state of Maharashtra, owing to the Campylobacter jejuni (C. jejuni) infection. The surge in cases has been considered as one of the most significant recorded GBS outbreaks globally, which underscores the need to raise GBS awareness. Method: This article provides an in-depth scientific perspective on GBS, drawing on literature from scientific databases such as PubMed and ScienceDirect. It aims to enhance awareness among science-related students, researchers, medical and paramedical professionals, and the general public. Result and discussion: GBS is an acute polyneuropathy characterized by limb weakness with hyporeflexia or areflexia. In severe forms, respiratory and bulbar paralysis can occur, requiring mechanical ventilatory support. It is the commonest cause of acute neuromuscular paralysis. The basic underlying mechanism of the disease is a localized attack against the myelin sheath of the peripheral nerves and nerve roots, with secondary axonal damage. It is believed that the bacterial antigens have a close molecular mimicry with neural antigens. As a result, the response generated against these antigens cross-reacts with the neural cells. Plasma exchange, immunoglobulin infusion, and plasmapheresis are the mainstays of treatment for GBS. Conclusion: A thorough understanding of GBS is essential, including its pathophysiology, underlying causes, risk factors, symptoms, diagnostic methods, treatment strategies, and the latest advancements

Understanding the Origin of Light Intensity and Temperature Dependence of Photodetection Properties in MAPbBr3 Single Crystal-based Photoconductor

Methylammonium lead bromide (MAPbBr3), which belongs to the larger material family of lead halide perovskites (LHPs), has emerged as a promising semiconductor for the fabrication of single crystal (SC) based photodetectors (PDs). However, there is still a lack of sufficient understanding of the effect of irradiation power and applied temperature on the photodetection performance of SC based perovskite PDs. Here, we investigate the impact of different light intensities and temperatures on the photodetection properties of planar-type MAPbBr3 SC based PD with the help of transient photoresponse and impedance spectroscopy. The light intensity-dependent study revealed that the key performance parameters of PD decrease with increasing irradiation intensity due to changes in charge recombination and carrier lifetime. On the other hand, the detrimental effect of increasing temperature on the performance of PD was found to be related to the ions accumulation, increasing scattering of impurities and phonons, change in conductivity and band gap rather than the change in charge recombination. This study provides a thorough understanding of the origin of light intensity and temperature-dependent photodetection properties of SC based PD, which is crucial for the further advancement of optoelectronic devices based on LHPs.National Science Centr

Metal-Doped MAPbBr3 Single Crystal p-n Junction Photodiode for Self-Powered Photodetection

Lead halide perovskites have emerged as the next-generation materials for self-powered photodetectors enabling operation without an external power source. In this study, a planar-type photodetector based on metal-doped p-type MAPbBr3/n-type MAPbBr3 single crystal showing excellent self-powered photodetection properties is presented. The p-n junction on the MAPbBr3 single crystal is formed by controlled epitaxial growth of Ag+-doped MAPbBr3 SC (p-type) on the facet of Sb3+-doped MAPbBr3 SC (n-type). The as-integrated p-n junction device with asymmetric electrodes shows a typical photovoltaic behavior with a high open circuit voltage of 0.95 V and great sensitivity to 530 nm illumination at zero bias with a responsivity of up to 0.41 A W−1 and a specific detectivity of 6.39 × 1011 Jones, which are among the highest values reported for MAPbBr3 single crystal-based self-powered photodetectors. In addition, the rise time and fall time of this device are as fast as 14 and 10 ms, respectively. These results pave the way for the fabrication of self-powered perovskite-based p-n junction photodiode, which may find potential application in advanced photodiode and future optoelectronic devices.National Science Centr