Caladan: a distributed meta-OS for data center disaggregation

Data center resource disaggregation promises cost savings by pool-ing compute, storage and memory resources into separate, net-worked nodes. The benefits of this model are clear, but a closer lookshows that its full performance and efficiency potential cannot beeasily realized. Existing systems use CPUs pervasively to interface ar-bitrary devices with the network and to orchestrate communicationamong them, reducing the benefits of disaggregation.In this paper we presentCaladan, a novel system with a trusteduni-versal resource fabricthat interconnects all resources and efficientlyoffloads the system and application control planes to SmartNICs,freeing server CPUs to execute application logic. Caladan offersthree core services: capability-driven distributed name space, virtualdevices, and direct inter-device communications. These servicesare implemented in a trustedmeta-kernelthat executes in per-nodeSmartNICs. Low-level device drivers running on the commodity hostOS are used for setting up accelerators and I/O devices, and exposingthem to Caladan. Applications run in a distributed fashion acrossCPUs and multiple accelerators, which in turn can directly performI/O, i.e., access files, other accelerators or host services. Our dis-tributed dataflow runtime runs on top of this substrate. It orchestratesthe distributed execution, connecting disaggregated resources usingdata transfers and inter-device communication, while eliminatingthe performance bottlenecks of the traditional CPU-centric design

Pyrazine as a building block for molecular architectures with PtII

A series of pyrazine (pz) complexes containing cis-(NH(3))(2)Pt(II), (tmeda)Pt(II) (tmeda = N,N,N',N'-tetramethylethylenediamine), and trans-(NH(3))(2)Pt(II) entities have been prepared and characterized by X-ray crystallography and/or (1)H NMR spectroscopy. In these compounds, the pz ligands act as monodentate (1-3) or bidentate bridging ligands (4-7). Three variants of the latter case are described: a dinuclear complex [Pt(II)](2) (4b), a cyclic tetranuclear [Pt(II)](4) complex (5), and a trinuclear mixed-metal complex [Pt(2)Ag] (7). Mono- and bidentate binding modes are readily differentiated by (1)H NMR spectroscopy, and the assignment of pz protons in the case of monodentate coordination is aided by the observation of (195)Pt satellites. Formation of the open molecular box cis-[{(NH(3))(2)Pt(pz)}(4)](NO(3))(8).3.67H(2)O (5) from cis-(NH(3))(2)Pt(II) and pz follows expectations of the "molecular library approach" for the generation of a cyclic tetramer

Prediction of Dermal Exposure to Chemical Substances Using a Fluorescence Method within the SysDEA Project

Abstract Dermal exposure is an important exposure route for occupational exposure and risk assessment. A fluorescence method has been developed to quantify occupational dermal exposure based on a visualization technique, using Tinopal SWN as a fluorescent tracer. The method was developed within the framework of a large experimental study, the SysDEA project. In SysDEA, dermal exposure was measured with different methods for 10 simulated exposure situations by sampling powder and liquid formulations containing Tinopal SWN on coveralls and patches and subsequently chemically analysing them. For the fluorescence method, photographs of exposed volunteers who performed the experiments were taken inside a room which consisted of an optimized arrangement of several UV irradiating tube light brackets, reflective and non-reflective backgrounds for maximum light diffusion and a camera. Image processing analysis software processed these photographs to obtain corresponding light intensity in terms of summed pixel values. To be able to estimate the amount of Tinopal SWN, 25% of the measured data from the SysDEA experiments were used to calibrate by correlating the summed pixel values from the photographs to actual measured exposure values using a second order regression model. For spraying both high and low viscosity liquids, showing uniformly distributed exposure patterns, strong Pearson correlation coefficients (R &amp;gt; 0.77) were observed. In contrast, the correlations were either inconsistently poor (R = −0.17 to 0.28 for pouring, rolling high viscosity liquid, manually handling objects immersed in low viscosity liquid and handling objects contaminated with powder), moderate (R = 0.73 for dumping of powder), or strong (R = 0.83 and 0.77 for rolling low viscosity liquid and manually handling objects immersed in high viscosity liquid). A model for spraying was developed and calibrated using 25% of the available experimental data for spraying and validated using the remaining 75%. Under given experimental conditions, the fluorescence method shows promising results and can be used for the quantification of dermal exposure for different body parts (excluding hands) for spraying-like scenarios that have a more uniform exposure pattern, but more research is needed for exposure scenarios with less uniform exposure patterns. For the estimation of exposure levels, the surface loading limit should be lower than 1.5░µg/cm2 (a lower limit could not be quantified based on experiments conducted in this study) on a large surface, like a coverall, which should be ideally perpendicular to the camera.</jats:p