CandidaDB: a multi-genome database for Candida species and related Saccharomycotina

CandidaDB (http://genodb.pasteur.fr/CandidaDB) was established in 2002 to provide the first genomic database for the human fungal pathogen Candida albicans. The availability of an increasing number of fully or partially completed genome sequences of related fungal species has opened the path for comparative genomics and prompted us to migrate CandidaDB into a multi-genome database. The new version of CandidaDB houses the latest versions of the genomes of C. albicans strains SC5314 and WO-1 along with six genome sequences from species closely related to C. albicans that all belong to the CTG clade of Saccharomycotina—Candida tropicalis, Candida (Clavispora) lusitaniae, Candida (Pichia) guillermondii, Lodderomyces elongisporus, Debaryomyces hansenii, Pichia stipitis—and the reference Saccharomyces cerevisiae genome. CandidaDB includes sequences coding for 54 170 proteins with annotations collected from other databases, enriched with illustrations of structural features and functional domains and data of comparative analyses. In order to take advantage of the integration of multiple genomes in a unique database, new tools using pre-calculated or user-defined comparisons have been implemented that allow rapid access to comparative analysis at the genomic scale

Extendable local partial clones

AbstractWe investigate interpolation and extrapolation properties of composition-closed sets of partial operations defined on an infinite set E. Considering local completeness (interpolation property) the structure of a maximal local partial clone is described via its intersections with the full partial clones on every finite k-element (k⩾2) subset of E. The criteria are established which characterize any finite domain partial operation that can be extended to an everywhere defined operation from the same local partial clone as well as the criteria describing a local partial clone (called extendable) in which every finite domain partial operation is extendable are given (extrapolation properties). Next the full list of partial orders on the countable set such that the partial clones of their partial n-endomorphisms are extendable is obtained. Finally, based on these criteria the description of all extendable maximal local partial clones defined on the countable set is provided

A Place under the Sun: Planning, Landscape and Participation in a Case of a Solar Powerplant in the Israeli Desert

Studies demonstrate the lack of common interpretations and rigorous methods for landscape assessments (LA) during design and siting of renewable energy (RES) facilities. Research shows how perceived landscape impacts influence public willingness to accept changes in the landscape. The connection between the effectiveness of LA procedures vis-à-vis the inclusion of the public in decision-making related to RES siting has received less attention. We, therefore, examine the role of LAs in planning via the eyes of policymakers and experts, and evaluate the capacity of current tools to influence the process. Additionally, we analyze the role (or lack thereof) of the public in LAs. Our unique case—one of the largest in the world thermo-solar “tower” plant, located near a small desert village—exemplifies the place for landscape consideration in national-level mega-infrastructure. Based on documents analysis and semi-structured interviews, the findings demonstrate the struggle between competing goals such as financial and temporal efficiency, RES targets, landscape protection, and public participation. We conclude that first, despite independent efforts to promote the latter two, there may be little connection between the assessment of landscape effects and public participation because there is no mechanism for post-evaluation of a project’s impacts, and any debates on the actual effects remain theoretical. Second, that landscape impacts of large-scape infrastructure can mainly be avoided in the stage of site location, and at this stage, the room for public input remains limited