Сравнительная оценка экспрессии молекул главного комплекса гистосовместимости в тканях пародонта и периферической крови больных генерализованным пародонтитом

Проведено порівняльні клініко-іммунологічні аналізи стану адгезивних молекул HLA-A, B, C і HLA-DR головного комплексу гістосумісності на місцевому рівні - в тканинах пародонта і периферичної крові хворих на ГП і відповідних антигенів моноклональних антитіл T і В-лімфоцитів. Не виявлено прямого кореляційного зв’язку між клінічним проявом запалення пародонту і загальносоматичним імунним статусом, що розкриває механізми локальних Т-клітинних характеристик імунних змін і зумовлює корекцію місцевої терапії.A comparative clinical and immunological analysis of adhesion molecules HLA-A, B, C and HLA-DR major histocompatibility complex at the local level - in periodontal tissues and peripheral blood of patients with SE and related antigen antibody monoklialnyh T and B lymphocytes. There were no direct connection between korellyatsionnoy clinical manifestation of periodontal inflammation and the immune status of the somatic, that reveals the mechanisms of local T-cell characteristics of the immune changes and determines the correction of local therapy

Combining Localization Cues and Source Model Constraints for Binaural Source Separation

We describe a system for separating multiple sources from a two-channel recording based on interaural cues and prior knowledge of the statistics of the underlying source signals. The proposed algorithm effectively combines information derived from low level perceptual cues, similar to those used by the human auditory system, with higher level information related to speaker identity. We combine a probabilistic model of the observed interaural level and phase differences with a prior model of the source statistics and derive an EM algorithm for finding the maximum likelihood parameters of the joint model. The system is able to separate more sound sources than there are observed channels in the presence of reverberation. In simulated mixtures of speech from two and three speakers the proposed algorithm gives a signal-to-noise ratio improvement of 1.7 dB over a baseline algorithm which uses only interaural cues. Further improvement is obtained by incorporating eigenvoice speaker adaptation to enable the source model to better match the sources present in the signal. This improves performance over the baseline by 2.7 dB when the speakers used for training and testing are matched. However, the improvement is minimal when the test data is very different from that used in training

Bryophytes of Uganda : 6., new and additional records, 3.

12 hepatics and 32 mosses are reported new to Uganda, 1 moss being also new to Africa, and 1 liverwort new to mainland Africa. Ectropothecium plumigerum (Broth.) Hedenäs is a new combination (basionym: Isopterygium plumigerum Broth.) with a new synonym Taxicaulis plumirameus Müll.Hal. nom. nud., and Taxiphyllum maniae (Renauld & Paris) M. Fleisch. is a new synonym of Taxiphyllum taxirameum (Mitt.) M.Fleisch. Three mosses are removed from the Uganda list

Age-dependent molecular alterations in the autophagy pathway in HIVE patients and in a gp120 tg mouse model: reversal with beclin-1 gene transfer.

Aged (>50 years old) human immunodeficiency virus (HIV) patients are the fastest-growing segment of the HIV-infected population in the USA and despite antiretroviral therapy, HIV-associated neurocognitive disorder (HAND) prevalence has increased or remained the same among this group. Autophagy is an intracellular clearance pathway for aggregated proteins and aged organelles; dysregulation of autophagy is implicated in the pathogenesis of Parkinson's disease, Alzheimer's disease, and HAND. Here, we hypothesized that dysregulated autophagy may contribute to aging-related neuropathology in HIV-infected individuals. To explore this possibility, we surveyed autophagy marker levels in postmortem brain samples from a cohort of well-characterized <50 years old (young) and >50 years old (aged) HIV+ and HIV encephalitis (HIVE) patients. Detailed clinical and neuropathological data showed the young and aged HIVE patients had higher viral load, increased neuroinflammation and elevated neurodegeneration; however, aged HIVE postmortem brain tissues showed the most severe neurodegenerative pathology. Interestingly, young HIVE patients displayed an increase in beclin-1, cathepsin-D and light chain (LC)3, but these autophagy markers were reduced in aged HIVE cases compared to age-matched HIV+ donors. Similar alterations in autophagy markers were observed in aged gp120 transgenic (tg) mice; beclin-1 and LC3 were decreased in aged gp120 tg mice while mTor levels were increased. Lentivirus-mediated beclin-1 gene transfer, that is known to activate autophagy pathways, increased beclin-1, LC3, and microtubule-associated protein 2 expression while reducing glial fibrillary acidic protein and Iba1 expression in aged gp120 tg mice. These data indicate differential alterations in the autophagy pathway in young versus aged HIVE patients and that autophagy reactivation may ameliorate the neurodegenerative phenotype in these patients

Clustering of Very Red Galaxies in the Las Campanas IR Survey

We report results from the first 1000 square arc-minutes of the Las Campanas IR survey. We have imaged 1 square degree of high latitude sky in six distinct fields to a 5-sigma H-band depth of 20.5 (Vega). Optical imaging in the V,R,I,and z' bands allow us to select color subsets and photometric-redshift-defined shells. We show that the angular clustering of faint red galaxies (18 3) is an order of magnitude stronger than that of the complete H-selected field sample. We employ three approaches to estimate $n(z)$ in order to invert w(theta) to derive r_0. We find that our n(z) is well described by a Gaussian with = 1.2, sigma(z) = 0.15. From this we derive a value for r_0 of 7 (+2,-1) co-moving H^{-1} Mpc at = 1.2. This is a factor of ~ 2 larger than the clustering length for Lyman break galaxies and is similar to the expectation for early type galaxies at this epoch.Comment: 5 pages, 2 figures, 1 table. To appear in proceedings of the ESO/ECF/STScI workshop "Deep Fields" held in Garching, Germany, 9-12 October 200

CNN Architectures for Large-Scale Audio Classification

Convolutional Neural Networks (CNNs) have proven very effective in image classification and show promise for audio. We use various CNN architectures to classify the soundtracks of a dataset of 70M training videos (5.24 million hours) with 30,871 video-level labels. We examine fully connected Deep Neural Networks (DNNs), AlexNet [1], VGG [2], Inception [3], and ResNet [4]. We investigate varying the size of both training set and label vocabulary, finding that analogs of the CNNs used in image classification do well on our audio classification task, and larger training and label sets help up to a point. A model using embeddings from these classifiers does much better than raw features on the Audio Set [5] Acoustic Event Detection (AED) classification task.Comment: Accepted for publication at ICASSP 2017 Changes: Added definitions of mAP, AUC, and d-prime. Updated mAP/AUC/d-prime numbers for Audio Set based on changes of latest Audio Set revision. Changed wording to fit 4 page limit with new addition

Kidney after nonrenal transplantation-the impact of alemtuzumab induction

BACKGROUND.: Calcineurin inhibitor nephrotoxicity in nonrenal allograft recipients can lead to end-stage renal disease and the need for kidney transplantation. We sought to evaluate the role of alemtuzumab induction in this population. PATIENTS AND METHODS.: We evaluated 144 patients undergoing kidney transplantation after nonrenal transplantation between May 18, 1998, and October 8, 2007. Seventy-two patients transplanted between January 15, 2003, and October 8, 2007, received alemtuzumab induction and continued their pretransplant immunosuppression. Seventy-two patients transplanted between May 18, 1998, and July 21, 2007, did not receive alemtuzumab induction, but received additional steroids and maintenance immunosuppression. Donor and recipient demographics were comparable. RESULTS.: Overall, 1-and 3-year patient survival and renal function were comparable between the two groups. One-and 3-year graft survival was 93.0% and 75.3% in the alemtuzumab group and 83.3% and 68.7% in the no alemtuzumab group, respectively (P=0.051). The incidence of acute rejection was lower in the alemtuzumab group, 15.3%, than in the no alemtuzumab group, 41.7% (P=0.0001). The incidence of delayed graft function was lower in the alemtuzumab group, 9.7%, than in the no alemtuzumab group, 25.0% (P=0.003). The incidence of viral complications was comparable. CONCLUSION.: Alemtuzumab induction with simple resumption of baseline immunosuppression in patients undergoing kidney transplantation after nonrenal transplantation represents a reasonable immunosuppressive strategy. Copyright © 2009 by Lippincott Williams & Wilkins