13 research outputs found
The Impact of Securities Litigation Reform on the Disclosure of Forward-Looking Information by High Technology Firms
No full text
The Implications of Voluntary Disclosure for Research on the Asymmetric Timeliness of Earnings
No full textDiscovery and in Vivo Evaluation of (<i>S</i>)‑<i>N</i>‑(1-(7-Fluoro-2-(pyridin-2-yl)quinolin-3-yl)ethyl)‑9<i>H</i>‑purin-6-amine (AMG319) and Related PI3Kδ Inhibitors for Inflammation and Autoimmune Disease
No full textThe development and optimization
of a series of quinolinylpurines
as potent and selective PI3Kδ kinase inhibitors with excellent
physicochemical properties are described. This medicinal chemistry
effort led to the identification of <b>1</b> (AMG319), a compound
with an IC<sub>50</sub> of 16 nM in a human whole blood assay (HWB),
excellent selectivity over a large panel of protein kinases, and a
high level of in vivo efficacy as measured by two rodent disease models
of inflammation
