Predictors of ICU Admission in Intentional Overdose Presentations to the Emergency Department

Objective: To identify predictors of admission to ICU for patients attending the emergency department (ED) after intentional drug overdose. Methods: A retrospective study examining factors predictive of ICU admission for adults > 15 years presenting to Christchurch ED with intentional overdose between 1 July 2018 and 31 December 2020. Descriptive statistics were used by treating all presentations independently and on a per‐patient basis to account for patients with repeat presentations or ICU admissions. Binary logistic models provided odds ratios with 95% confidence intervals. A multivariable logistic regression model which controlled for patients with ≥ 3 ED presentations in the past 365 days was used to determine predictors of ICU admission. Result: There were 2682 presentations to ED with intentional overdose from 1795 individual patients, with 113 associated ICU admissions (4.2%) involving 103 patients. Overdose was more common in those who were younger, of female sex, or with a mental health history. The rate of overdose by Māori patients was double the rate expected. Older age, reduced level of consciousness, polypharmacy or cardiac drug overdose, and a history of depression, substance abuse or ADHD, ASD, learning difficulties or previous head injury were independently associated with an increased risk of ICU admission. Paracetamol ingestion and a history of ≥ 3 ED presentations in the preceding year were independently associated with a lower risk of ICU admission. Conclusion: The need for ICU admission in patients presenting with intentional overdose should be identified early to prevent deterioration, promote flow through the hospital, and ensure that ICU beds are utilised appropriately

Oxygen targets and 6-month outcome after out of hospital cardiac arrest: a pre-planned sub-analysis of the targeted hypothermia versus targeted normothermia after Out-of-Hospital Cardiac Arrest (TTM2) trial

International audienceAbstract Background Optimal oxygen targets in patients resuscitated after cardiac arrest are uncertain. The primary aim of this study was to describe the values of partial pressure of oxygen values (PaO 2 ) and the episodes of hypoxemia and hyperoxemia occurring within the first 72 h of mechanical ventilation in out of hospital cardiac arrest (OHCA) patients. The secondary aim was to evaluate the association of PaO 2 with patients’ outcome. Methods Preplanned secondary analysis of the targeted hypothermia versus targeted normothermia after OHCA (TTM2) trial. Arterial blood gases values were collected from randomization every 4 h for the first 32 h, and then, every 8 h until day 3. Hypoxemia was defined as PaO 2  300 mmHg. Mortality and poor neurological outcome (defined according to modified Rankin scale) were collected at 6 months. Results 1418 patients were included in the analysis. The mean age was 64 ± 14 years, and 292 patients (20.6%) were female. 24.9% of patients had at least one episode of hypoxemia, and 7.6% of patients had at least one episode of severe hyperoxemia. Both hypoxemia and hyperoxemia were independently associated with 6-month mortality, but not with poor neurological outcome. The best cutoff point associated with 6-month mortality for hypoxemia was 69 mmHg (Risk Ratio, RR = 1.009, 95% CI 0.93–1.09), and for hyperoxemia was 195 mmHg (RR = 1.006, 95% CI 0.95–1.06). The time exposure, i.e., the area under the curve (PaO 2 -AUC), for hyperoxemia was significantly associated with mortality ( p = 0.003). Conclusions In OHCA patients, both hypoxemia and hyperoxemia are associated with 6-months mortality, with an effect mediated by the timing exposure to high values of oxygen. Precise titration of oxygen levels should be considered in this group of patients. Trial registration : clinicaltrials.gov NCT02908308 , Registered September 20, 2016

Ventilatory settings in the initial 72 h and their association with outcome in out-of-hospital cardiac arrest patients: a preplanned secondary analysis of the targeted hypothermia versus targeted normothermia after out-of-hospital cardiac arrest (TTM2) trial

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