Mediterranean diet and cardiodiabesity: a review

Cardiodiabesity has been used to define and describe the well-known relationship between type 2 Diabetes Mellitus (T2DM), obesity, the metabolic syndrome (MetS) and cardiovascular disease (CVD). The objective of this study was to perform a scientific literature review with a systematic search to examine all the cardiovascular risk factors combined and their relationship with adherence to the Mediterranean Diet (MedDiet) pattern as primary prevention against cardiodiabesity in a holistic approach. Research was conducted using the PubMed database including clinical trials, cross-sectional and prospective cohort studies. Thirty-seven studies were reviewed: fourteen related to obesity, ten to CVD, nine to MetS, and four to T2DM. Indeed 33 provided strong evidence on the association between adherence to a MedDiet and a reduced incidence of collective cardiodiabesity risk in epidemiological studies. This scientific evidence makes the MedDiet pattern very useful for preventive strategies directed at the general population and also highlights the need to consider all these diet-related risk factors and health outcomes together in daily primary care

The Bone Resorption Inhibitors Odanacatib and Alendronate Affect Post-Osteoclastic Events Differently in Ovariectomized Rabbits

Odanacatib (ODN) is a bone resorption inhibitor which differs from standard antiresorptives by its ability to reduce bone resorption without decreasing bone formation. What is the reason for this difference? In contrast with other antiresorptives, such as alendronate (ALN), ODN targets only the very last step of the resorption process. We hypothesize that ODN may therefore modify the remodeling events immediately following osteoclastic resorption. These events belong to the reversal phase and include recruitment of osteoblasts, which is critical for connecting bone resorption to formation. We performed a histomorphometric study of trabecular remodeling in vertebrae of estrogen-deficient rabbits treated or not with ODN or ALN, a model where ODN, but not ALN, was previously shown to preserve bone formation. In line with our hypothesis, we found that ODN treatment compared to ALN results in a shorter reversal phase, faster initiation of osteoid deposition on the eroded surfaces, and higher osteoblast recruitment. The latter is reflected by higher densities of mature bone forming osteoblasts and an increased subpopulation of cuboidal osteoblasts. Furthermore, we found an increase in the interface between osteoclasts and surrounding osteoblast-lineage cells. This increase is expected to favor the osteoclast–osteoblast interactions required for bone formation. Regarding bone resorption itself, we show that ODN, but not ALN, treatment results in shallower resorption lacunae, a geometry favoring bone stiffness. We conclude that, compared to standard antiresorptives, ODN shows distinctive effects on resorption geometry and on reversal phase activities which positively affect osteoblast recruitment and may therefore favor bone formation

Evaluation of the anisotropic mechanical properties of reinforced polyurethane foams

The mechanical impact of adding milled glass fibers and nanoparticles at different mass fractions to low-density (relative density < 0.2) polyurethane (PU) foams is investigated. Tensile, compressive, and shear stress–strain curves are measured in the plane parallel to the foam-rise direction and the in-plane components of the elastic modulus are determined in order to assess the mechanical anisotropy of the foams. Power-law relationships between the moduli and apparent density are established for pure PU foams and used as a baseline to which the properties of composite foams are compared. Cellular mechanics models based on both rectangular and Kelvin unit-cell geometries are employed to estimate changes in the cell shape based on the mechanical anisotropy of composite foams, and the model results are compared with direct observations of the cellular structure from microscopy. A single measure of foam stiffness reinforcement is defined that excludes the effects of the apparent foam density and cell shape. The analysis reveals the large impact of cell shape on the moduli of the glass-fiber and nanocomposite foams. Nanocomposite foams exhibit up to an 11.1% degree of reinforcement, and glass-fiber foams up to 18.7% using this method for quantifying foam reinforcement, whereas a simple normalization to the in-plane modulus components of the pure PU foam would indicate from ?40.5% to 25.9% reinforcement in nanocomposite foams, and ?7.5 to 20.2% in glass-fiber foams