Verb generation in children with spina bifida.

We investigated verb generation in children with spina bifida meningomyelocele (SBM; n = 55) and in typically developing controls (n = 32). Participants completed 6 blocks (40 trials each) of a task requiring them to produce a semantically related verb in response to a target noun and an additional 40 trials on which they were simply required to read target nouns aloud. After controlling for reading response time, groups did not differ significantly in verb generation response time or learning. Children with SBM produced more non-verb errors than controls and tended to repeat their mistakes over blocks. Verb generation performance was associated with brain volume measures in participants with SBM. Congenital cerebellar dysmorphology is associated with impaired performance in verb generation accuracy, although not with increased response times to produce verb

The roles of moral psychology in the philosophy of John Rawls

This thesis explicates and critically considers the various roles played by moral psychology within the work of John Rawls throughout his career. In the second half of the 20th Century, Rawls’s development of a sophisticated theory of justice in the social contract tradition played a significant part in reviving the study of normative political philosophy in the western world. Rawls argued that any theory of justice must be closely integrated with our best contemporary understanding of human psychology. Moral psychology is hence widely recognised to play an important role in Rawls’s overall theory. But the precise role played has not been adequately examined. In this thesis, I identify six roles which moral psychology plays within the structure of Rawls’s theory. Moral psychology must defend the idea that the model for a just society which Rawls proposes is realisable and stable (role #1). Moral psychology is also employed to explain how persons now have acquired what sense of justice they have (role #2). By showing that Rawls’s just society can be realised and is stable, moral psychology is then subsequently used in the justification of Rawls’s theory of justice – first by showing that such a society is not futile (role #3), and second by showing that the society is comparatively more stable than leading rivals (role #4). The account of the psychological capacities of the moral person is used to place the limit on the scope of justice (role #5). And moral psychological facts are also likely to be, in some sense, constitutive of the nature of morality for Rawls (role #6). These roles are discussed throughout various chapters. What alterations occur to the overall place of moral psychology following Rawls’s later embrace of political liberalism is also discussed. The overall aim of the thesis is to produce an accurate exegesis on these matters, and in doing so indicate just how important moral psychology is within Rawls’s theory, but also to indicate, clearly and starkly, just how much more psychological and sociological investigation needs to be done in if the theory is to be substantiated, given Rawls’s own criteria

Altered Neurocircuitry in the Dopamine Transporter Knockout Mouse Brain

The plasma membrane transporters for the monoamine neurotransmitters dopamine, serotonin, and norepinephrine modulate the dynamics of these monoamine neurotransmitters. Thus, activity of these transporters has significant consequences for monoamine activity throughout the brain and for a number of neurological and psychiatric disorders. Gene knockout (KO) mice that reduce or eliminate expression of each of these monoamine transporters have provided a wealth of new information about the function of these proteins at molecular, physiological and behavioral levels. In the present work we use the unique properties of magnetic resonance imaging (MRI) to probe the effects of altered dopaminergic dynamics on meso-scale neuronal circuitry and overall brain morphology, since changes at these levels of organization might help to account for some of the extensive pharmacological and behavioral differences observed in dopamine transporter (DAT) KO mice. Despite the smaller size of these animals, voxel-wise statistical comparison of high resolution structural MR images indicated little morphological change as a consequence of DAT KO. Likewise, proton magnetic resonance spectra recorded in the striatum indicated no significant changes in detectable metabolite concentrations between DAT KO and wild-type (WT) mice. In contrast, alterations in the circuitry from the prefrontal cortex to the mesocortical limbic system, an important brain component intimately tied to function of mesolimbic/mesocortical dopamine reward pathways, were revealed by manganese-enhanced MRI (MEMRI). Analysis of co-registered MEMRI images taken over the 26 hours after introduction of Mn^(2+) into the prefrontal cortex indicated that DAT KO mice have a truncated Mn^(2+) distribution within this circuitry with little accumulation beyond the thalamus or contralateral to the injection site. By contrast, WT littermates exhibit Mn^(2+) transport into more posterior midbrain nuclei and contralateral mesolimbic structures at 26 hr post-injection. Thus, DAT KO mice appear, at this level of anatomic resolution, to have preserved cortico-striatal-thalamic connectivity but diminished robustness of reward-modulating circuitry distal to the thalamus. This is in contradistinction to the state of this circuitry in serotonin transporter KO mice where we observed more robust connectivity in more posterior brain regions using methods identical to those employed here

Repairing political trust for practical sustainability

High levels of trust in government are important in addressing complex issues, including the realization of the mainstream sustainability agenda. However, trust in government has been declining for decades across the western world, undermining legitimacy and hampering policy implementation and planning for long-term sustainability. We hypothesize that an important factor in this decline is citizen disappointment with the current types of public participation in governance and that this could be reversed through a change from informing/consulting to a relationship of partnership. Using case studies from Western Australia, the paper investigates whether an intervention targeted at establishing a partnership relationship through mini-public, deliberative, participatory budgeting would improve trust and help the implementation of sustainability. These results show evidence of improvements in trust and provide conceptual and practical tools for government administrations wishing to close the detrimental trust gap that may hamper the implementation of a sustainability agenda

Towards an understanding of the information and support needs of surgical adolescent idiopathic scoliosis patients: a qualitative analysis

<p>Abstract</p> <p>Background</p> <p>Informed decision making for adolescents and families considering surgery for scoliosis requires essential information, including expected outcomes with or without treatment and the associated risks and benefits of treatment. Ideally families should also receive support in response to their individual concerns. The aim of this study was to identify health-specific needs for online information and support for patients with adolescent idiopathic scoliosis who have had or anticipate having spinal surgery.</p> <p>Methods</p> <p>Focus group methodology was chosen as the primary method of data collection to encourage shared understandings, as well as permit expression of specific, individual views. Participants were considered eligible to participate if they had either experienced or were anticipating surgery for adolescent idiopathic scoliosis within 12 months, were between the ages of 10 and 18 years of age, and were English-speaking.</p> <p>Results</p> <p>Two focus groups consisting of 8 adolescents (1 male, 7 female) and subsequent individual interviews with 3 adolescents (1 male, 2 female) yielded a range of participant concerns, in order of prominence: (1) recovery at home; (2) recovery in hospital; (3) post-surgical appearance; (4) emotional impact of surgery and coping; (5) intrusion of surgery and recovery of daily activities; (6) impact of surgery on school, peer relationships and other social interactions; (7) decision-making about surgery; (8) being in the operating room and; (9) future worries.</p> <p>Conclusion</p> <p>In conclusion, adolescents welcomed the possibility of an accessible, youth-focused website with comprehensive and accurate information that would include the opportunity for health professional-moderated, online peer support.</p

Cross-Sectional Study Protocol for the COVID-19 Impact Survey of Mothers and Their 7–11 Year Old Children in Alberta, Canada

Objectives: Our aim is to understand the effect of the COVID-19 pandemic on families who have been followed longitudinally in two cohorts studied in Alberta, Canada. We will examine household infections during the COVID-19 pandemic, financial impact, domestic violence, substance use, child school and daily life and relationships in the home. We will identify risk and protective factors for maternal mental health outcomes using longitudinal data that can inform policy and government resource allocation in future disasters.Methods: Mothers who are currently participating in two longitudinal studies, Alberta Pregnancy Outcomes and Nutrition (APrON; N = 1,800) and All Our Families (AOF: N = 2,534) were eligible to participate. Mothers were invited to complete the baseline COVID-19 Impact Survey (20–30 min) within 4 months of March 15, 2020, which was when the province of Alberta, Canada, implemented school closures and physical-distancing measures to prevent the spread of COVID-19. Mothers were asked to report on their own, their child's and their family's functioning. Mothers were re-surveyed at 6 months after completion of the initial COVID-19 Impact Survey, and will be re-surveyed again at 12 months.Results: Responses from participants in both cohorts will be examined in harmonized analyses as well as separately. Descriptive, multivariable analysis will be undertaken to examine risk and resiliency over time and factors that predict mental health and well-being.Conclusions: This study will provide timely information on the impact of COVID-19 for Albertan families. It will identify risk and protective factors for mental health and well-being among contemporary urban families supported by a publicly funded health care system to inform allocation of resources to support those most vulnerable during a global pandemic

Adaptive Neuro-Fuzzy Inference System integrated with solar zenith angle for forecasting sub-tropical photosynthetically active radiation

Advocacy for climate mitigation aims to minimize the use of fossil fuel and to support clean energy adaptation. While alternative energies (e.g., biofuels) extracted from feedstock (e.g., micro‐algae) represent a promising role, their production requires reliably modeled photosynthetically active radiation (PAR). PAR models predict energy parameters (e.g., algal carbon fixation) to aid in decision‐making at PAR sites. Here, we model very short‐term (5‐min scale), sub‐tropical region's PAR with an Adaptive Neuro‐Fuzzy Inference System model with a Centroid‐Mean (ANFIS‐CM) trained with a non‐climate input (i.e., only the solar angle, θZ). Accuracy is benchmarked against genetic programming (GP), M5Tree, Random Forest (RF), and multiple linear regression (MLR). ANFIS‐CM integrates fuzzy and neural network algorithms, whereas GP adopts an evolutionary approach, M5Tree employs binary decision, RF employs a bootstrapped ensemble, and MLR uses statistical tools to link PAR with θZ. To design the ANFIS‐CM model, 5‐min θZ (01–31 December 2012; 0500H–1900H) for sub‐tropical, Toowoomba are utilized to extract predictive features, and the testing accuracy (i.e., differences between measurements and forecasts) is evaluated with correlation (r), root‐mean‐square error (RMSE), mean absolute error (MAE), Willmott (WI), Nash–Sutcliffe (ENS), and Legates & McCabes (ELM) Index. ANFIS‐CM and GP are equivalent for 5‐min forecasts, yielding the lowest RMSE (233.45 and 233.01μ mol m−2s−1) and MAE (186.59 and 186.23 μmol m−2s−1). In contrast, MLR, M5Tree, and RF yields higher RMSE and MAE [(RMSE = 322.25 μmol m−2s−1, MAE = 275.32 μmol m−2s−1), (RMSE = 287.70 μmol m−2s−1, MAE = 234.78 μmol m−2s−1), and (RMSE = 359.91 μmol m−2s−1, MAE = 324.52 μmol m−2s−1)]. Based on normalized error, ANFIS‐CM is considerably superior (MAE = 17.18% versus 19.78%, 34.37%, 26.39%, and 30.60% for GP, MLR, M5Tree, and RF models, respectively). For hourly forecasts, ANFIS‐CM outperforms all other methods (WI = 0.964 vs. 0.942, 0.955, 0.933 & 0.893, and ELM = 0.741 versus 0.701, 0.728, 0.619 & 0.490 for GP, MLR, M5Tree, and RF, respectively). Descriptive errors support the versatile predictive skills of the ANFIS‐CM model and its role in real‐time prediction of the photosynthetic‐active energy to explore biofuel generation from micro‐algae, studying food chains, and supporting agricultural precision