A modified new method for estimating smoking-attributable mortality in high-income countries

Preston, Glei, and Wilmoth (2010) recently proposed an innovative regression-based method to estimate smoking-attributable mortality in developed countries based on observed lung cancer death rates. Their estimates for females, however, differ appreciably from some published estimates. This article presents a modified version of the Preston, Glei, and Wilmoth method that includes an age-period interaction term in its model. This modified version produces improved estimates of smoking-attributable mortality that are consistent with results from a modified version of the Peto-Lopez indirect method.life expectancy, mortality, smoking

A Sense of Duty: Retiring the Special Relationship Rule and Holding Gun Manufacturers Liable for Negligently Distributing Guns

In response to recent litigation brought against the gun industry on behalf of individuals and municipalities victimized as a result of the negligent marketing, design, and distribution of guns, the gun industry has argued that they cannot be held responsible for the victims\u27 injuries because they have no special relationship with the victims. Without a special relationship, gun manufacturers claim to have no duty whatsoever to design, market, or distribute guns in a reasonable fashion. This article examines the fallacies inherent in the gun industry\u27s special relationship argument and discusses the factual, legal and policy grounds that support holding the gun industry responsible for its role in facilitating the misuse of guns

Heroes and Helpers, Victims and Villains: A syntagmatic analysis of manager stories

This paper builds on the growing body of work using narrative as a means of both conceptualising and researching identity. Drawing on the work of Propp, it presents a method of syntagmatic analysis which attends to the narrative plots underpinning stories, and the narrative roles adopted by the narrator and roles ascribed to others. The paper presents research into manager workplace identities at a UK Social Landlord. It demonstrates how a syntagmatic analysis of manager stories reveals rich insights into the workplace identities of managers, and the identity work they undertake in order to construct and sustain such identities. It further reveals how managers personally position themselves in relation to the range of possible organisational functions of a manager, and in relation to the organisation and other organisational actors. By attending to individual stories, such analysis also draws attention to the plurality of manager experience

Incrementalism, Comprehensive Rationality, and the Future of Gun Control

This article examines the issue of gun control through the lens of the \u27comprehensive rationality\u27 and \u27incrementalism\u27 models of policymaking and argues that incremental policymaking has been one of the major impediments to progress toward more effective regulation of guns. Gun laws are often an incoherent patch-work of provisions as new restrictions are piled atop old ones in response to particular tragedies or narrow concerns, instead of crafting bills to achieve an optimal approach to the entire problem. Political science and other social sciences literature has closely examined the \u27incrementalism\u27 and \u27comprehensive rationality\u27 models of policymaking over the past several decades, but legal scholars discuss the models much less frequently. This article describes how political scientists have identified a few exceptional types of policy problems that are particularly unsuited for an incrementalist approach. Incremental policymaking poses a special risk for firearm regulation because of the uniquely prominent role that \u27slippery slope\u27 fears play in the opposition to any new measures concerning guns. This article contends that a more comprehensive approach is vital both to achieve more effective policies and to quell gun owners\u27 concerns that moderate gun control measures will eventually lead to gun bans and confiscation. The top policy priority should be expanding background check regulations to form a more complete and coherent system limiting access to guns

The impact of a sport psychology education intervention on physiotherapists

The purpose of this study was to measure the impact of an online sport psychology education module on the attitudes and behaviours of qualified sports physiotherapists in the UK. Ninety-five sport physiotherapists studied either a sport psychology module or a control module, and their attitudes and behaviours towards sport psychology were measured prior to studying the module and at three points over a six-month period following its completion. It was found that those who had studied the sport psychology module demonstrated an improvement in their attitudes towards sport psychology immediately following its completion that was significantly higher than those who had studied the control module. Use of sport psychology also increased following the sport psychology module, with significant differences seen between the intervention and control group on the sport psychology subscale, indicating that those who had studied the sport psychology module were integrating more sport psychology techniques into their practice than those who had studied the control module. It was concluded that the online sport psychology module was effective in improving the attitudes and behaviours of UK physiotherapists and that more sport psychology education opportunities should be made available

The development of a safety and quality culture assessment tool from a longitudinal, mixed method research journey

Purpose The purpose of this paper is to describe the 16-year research and development journey of the Culture Excellence assessment tool, which is used widely to assess safety and quality culture in the food industry. It is the third article in a theme issue of Worldwide Hospitality and Tourism Themes, discussing the importance of measuring food safety and quality culture. Design/methodology/approach An iterative process of in-depth interviews and mixed-method case studies led to the development of a conceptual model and an online assessment tool, which are used to gain insight into safety and quality culture. Findings The research process resulted in a conceptual model of four categories and 20 dimensions of safety and quality culture, alongside a practical online assessment tool to enable their measurement; these categories and dimensions are demonstrated using qualitative quotations. Originality/value This paper introduces qualitative data on safety and quality culture direct from the food industry with academic analysis to highlight new dimensions and issues. It will be of value to food safety and quality practitioners, trainers, auditors and other stakeholders involved in the food industry

Cost effective, robust estimation of measurement uncertainty from sampling using unbalanced ANOVA

There is an increasing appreciation that the uncertainty in environmental measurements is vitally important for their reliable interpretation. However, the adoption of methods to estimate this uncertainty has been limited by the extra cost of implementation. One method that can be used to estimate the random components of uncertainty in the sampling and analytical processes requires the collection of duplicate samples at 10% of the primary sampling locations, and duplicating the analyses of these samples. A new program has been written and applied to a modified experimental design to enable a 33% reduction in the cost of analysing this 10% subset, whilst accommodating outlying values. This unbalanced robust analysis of variance (U-RANOVA) uses an unbalanced rather than the balanced experimental design usually employed. Simulation techniques have been used to validate the results of the program, by comparison of the results between the proposed unbalanced and the established balanced designs. Comparisons are also made against the seed parameters (mean and standard deviation) used to simulate the parent population, prior to the addition of a proportion (up to 10%) of outlying values. Application to a large number of different simulated populations shows that U-RANOVA produces results that are effectively indistinguishable from the results produced by the accepted balanced approach, and are equally close to the true (seed) parameters of the parent normal populatio

Interactions of short-term and chronic treadmill training with aging of the left ventricle of the heart

With aging, there is a decline in cardiac function accompanying increasing risk of arrhythmias. These effects are likely to be mechanistically associated with age-associated changes in calcium regulation within cardiac myocytes. Previous studies suggest that lifelong exercise can potentially reduce age-associated changes in the heart. Although exercise itself is associated with changes in cardiac function, little is known about the interactions of aging and exercise with respect to myocyte calcium regulation. To investigate this, adult (12 months) and old (24 months) C57/Bl6 mice were trained using moderate-intensity treadmill running. In response to 10 weeks’ training, comparable cardiac hypertrophic responses were observed, although aging independently associated with additional cardiac hypertrophy. Old animals also showed increased L- and T-type calcium channels, the sodium–calcium exchange, sarcoendoplasmic reticulum calcium ATPase, and collagen (by 50%, 92%, 66%, 88%, and 113% respectively). Short-term exercise training increased D-type and T-type calcium channels in old animals only, whereas an increase in sodium–calcium exchange was seen only in adult animals. Long-term (12 months) training generally opposed the effects of aging. Significant hypertrophy remained in long-term trained old animals, but levels of sarcoendoplasmic reticulum calcium ATPase, sodium–calcium exchange, and collagen were not significantly different from those found in the adult trained animals

Baffle Type Energy Dissipator for Pipe Outlets

The baffle type energy dissipator described in this paper was developed through laboratory experimentation for use in soil conservation work. It is designed to reduce the energy in high velocity pipe flow so that the water may be discharged safely into an erodible channel. This structure can be adapted to meet the many field conditions encountered in erosion control work in agriculture and elsewhere, such as at pipe outlets draining terraces or ditches, highway culverts, and drop inlet spillway outlets. Pipe sizes commonly used in such applications range from 10 to 48 in in diameter and have flows from 10 to 250 cfs discharging into channels of various widths

The cardiomyocyte "redox rheostat": Redox signalling via the AMPK-mTOR axis and regulation of gene and protein expression balancing survival and death.

Reactive oxygen species (ROS) play a key role in development of heart failure but, at a cellular level, their effects range from cytoprotection to induction of cell death. Understanding how this is regulated is crucial to develop novel strategies to ameliorate only the detrimental effects. Here, we revisited the fundamental hypothesis that the level of ROS per se is a key factor in the cellular response by applying different concentrations of H2O2 to cardiomyocytes. High concentrations rapidly reduced intracellular ATP and inhibited protein synthesis. This was associated with activation of AMPK which phosphorylated and inhibited Raptor, a crucial component of mTOR complex-1 that regulates protein synthesis. Inhibition of protein synthesis by high concentrations of H2O2 prevents synthesis of immediate early gene products required for downstream gene expression, and such mRNAs (many encoding proteins required to deal with oxidant stress) were only induced by lower concentrations. Lower concentrations of H2O2 promoted mTOR phosphorylation, associated with differential recruitment of some mRNAs to the polysomes for translation. Some of the upregulated genes induced by low H2O2 levels are cytoprotective. We identified p21Cip1/WAF1 as one such protein, and preventing its upregulation enhanced the rate of cardiomyocyte apoptosis. The data support the concept of a "redox rheostat" in which different degrees of ROS influence cell energetics and intracellular signalling pathways to regulate mRNA and protein expression. This sliding scale determines cell fate, modulating survival vs death