Precision Electroweak Measurements at the SLC : Overview and Perspective

Preliminary SLD electroweak results based on essentially the complete 550K Z dataset are presented and interpreted, and some historical background is provided.Comment: 5 pages, 2 figures, from "Weak Interactions and Neutrinos, 1999", Feb. 199

RIOT: a simple graphical assembly tool

Errors in the chip assembly process are harder to find than errors in cell design, since they belong to no specific part of the design, but rather to the assembly as a whole. Assembly errors are more costly than call design errors also, since they often go unnoticed until late in the design cycle. Interactive graphic tools typically require that assembly be done with primitive graphical operations, which are inappropriate far the assembly task. Language-based tools give more powerful assembly operations, but remove the two dimensional view of the chip necessary to visualize many assembly operations. Riot is a simple Interactive graphical tool designed to facilitate the assembly of cells into integrated systems. Riot supplies the user with primitive operations of connection -- abutment, routing and stretching - in an interactive graphic environment. Thus, the designer retains full control of the design, including the assignment of positions to instances of cells and the choice of connection mechanism. The computer takes care of the tedious and exacting implementation detail, guaranteeing that connections are actually made. The powerful connection primitives give the user of Riot the ability to quickly assemble a custom chip from a collection of low-level cells. This document provides a discussion of the motivation for Riot and a description of the Riot chip assembly system, its capabilities and its use

Revision of Dadagulella gen. nov., the “Gulella radius group” (Gastropoda: Streptaxidae) of the eastern Afrotropics, including six new species and three new subspecies

The genus Dadagulella gen. nov. is described to include 16 species of small, dentate, ovateacuminate Afrotropical snails. An identification key is provided and biogeography, anatomy and systematics are discussed. The type species is the Kenyan D. radius (Preston, 1910) comb. nov., whose name has informally been used for part of the group in the past. Substantial intraspecific variation occurs in three species: D. radius itself, D. browni (van Bruggen, 1969) comb. nov. and D. minuscula (Morelet, 1877) comb. nov. (= Ennea fi scheriana Morelet, 1881) (non Gulella minuscula Emberton & Pearce, 2000) . We recognise subspecies within each of these: D.radius radius (Preston, 1910) comb. nov., D. r. calva (Connolly, 1922) comb. et stat. nov., D. browni browni (van Bruggen, 1969) comb. nov., D. b. mafi ensis subsp. nov., D. b. semulikiensis subsp. nov., D. minuscula minuscula (Morelet, 1877) comb. nov., D. m. mahorana subsp. nov. Six new Tanzanian species are described: D. cresswelli sp. nov., D. delta sp. nov., D. ecclesiola sp. nov., D. frontierarum sp. nov., D. minareta sp. nov., and D. pembensis sp. nov. The genus includes seven other previously described species: D. cuspidata (Verdcourt, 1962) comb. nov.; D. rondoensis (Verdcourt, 1994) comb. nov.; D. conoidea (Verdcourt, 1996) comb. nov.; D. selene (van Bruggen & Van Goethem, 1999) comb. nov.; D. meredithae (van Bruggen, 2000) comb. nov.; D. nictitans (Rowson & Lange, 2007) comb. nov.; and D. delgada (Muratov, 2010) comb. nov

Compassion-focused perceptual positions

This article focuses on the perceptual position (or ‘empty chair’) technique adapted to fit the aims of compassion-focused coaching. I will briefly review the key principles of the compassion-focused approach and discuss why and how this technique can be used in coaching practice

Experimental Issues for Precision Electroweak Physics at a High-Luminosity Z Factory

We discuss the ultimate precision for ALR, and therefore for the weak mixing angle, at a high-luminosity Linear Collider. Drawing on our experience at the SLC, and considering various machine parameter sets for the NLC and for TESLA, it emerges that a compromise between peak luminosity and precision will be a likely outcome. This arises due to the severe requirements on the uncertainty in the luminosity weighted collision energy (Ecm). We consider the cases with and without a polarized positron beam.Comment: Submitted to LCWS2000 (Linear Collider Workshop 20000), Fermilab, 10-24-200

Neoplastic transformation of porcine mammary epithelial cells in vitro and tumor formation in vivo.

BackgroundThe mammary glands of pigs share many functional and morphological similarities with the breasts of humans, raising the potential of their utility for research into the mechanisms underlying normal mammary function and breast carcinogenesis. Here we sought to establish a model for the efficient manipulation and transformation of porcine mammary epithelial cells (pMEC) in vitro and tumor growth in vivo.MethodsWe utilized a vector encoding the red florescent protein tdTomato to transduce populations of pMEC from Yorkshire -Hampshire crossbred female pigs in vitro and in vivo. Populations of primary pMEC were then separated by FACS using markers to distinguish epithelial cells (CD140a-) from stromal cells (CD140a+), with or without further enrichment for basal and luminal progenitor cells (CD49f+). These separated pMEC populations were transduced by lentivirus encoding murine polyomavirus T antigens (Tag) and tdTomato and engrafted to orthotopic or ectopic sites in immunodeficient NOD.Cg-Prkdc (scid) Il2rg (tm1Wjl) /SzJ (NSG) mice.ResultsWe demonstrated that lentivirus effectively transduces pMEC in vitro and in vivo. We further established that lentivirus can be used for oncogenic-transformation of pMEC ex vivo for generating mammary tumors in vivo. Oncogenic transformation was confirmed in vitro by anchorage-independent growth, increased cell proliferation, and expression of CDKN2A, cyclin A2 and p53 alongside decreased phosphorylation of Rb. Moreover, Tag-transformed CD140a- and CD140a-CD49f + pMECs developed site-specific tumors of differing histopathologies in vivo.ConclusionsHerein we establish a model for the transduction and oncogenic transformation of pMEC. This is the first report describing a porcine model of mammary epithelial cell tumorigenesis that can be applied to the study of human breast cancers

RIOT -- A Simple Graphical Chip Assembly Tool

Riot is a simple interactive graphical tool designed to facilitate the assembly of cells into integrated systems. Riot supplies the user with primitive operations of connection -- abutment, routing and stretching -- in an interactive graphic environment. The designer retains full control of the design, including the assignment of positions to instances of cells and the choice of connection mechanism. The computer takes care of the tedious and exacting implementation detail, guaranteeing that connections are made correctly. The powerful connection primitives give the user of Riot the ability to quickly assemble a custom chip from a collection of low-level cells. This document provides a discussion of the motivation for Riot and a description of the Riot chip assembly system, its capabilities and its use

Highlights of the SLD Physics Program at the SLAC Linear Collider

Starting in 1989, and continuing through the 1990s, high-energy physics witnessed a flowering of precision measurements in general and tests of the standard model in particular, led by e+e- collider experiments operating at the Z0 resonance. Key contributions to this work came from the SLD collaboration at the SLAC Linear Collider. By exploiting the unique capabilities of this pioneering accelerator and the SLD detector, including a polarized electron beam, exceptionally small beam dimensions, and a CCD pixel vertex detector, SLD produced a broad array of electroweak, heavy-flavor, and QCD measurements. Many of these results are one of a kind or represent the world's standard in precision. This article reviews the highlights of the SLD physics program, with an eye toward associated advances in experimental technique, and the contribution of these measurements to our dramatically improved present understanding of the standard model and its possible extensions.Comment: To appear in 2001 Annual Review of Nuclear and Particle Science; 78 pages, 31 figures; A version with higher resolution figures can be seen at http://www.slac.stanford.edu/pubs/slacpubs/8000/slac-pub-8985.html; Second version incorporates minor changes to the tex