Structural Fluctuations in the Spin Liquid State of Tb2Ti2O7

High resolution X-ray scattering measurements on single crystal Tb2Ti2O7 reveal finite structural correlations at low temperatures. This geometrically frustrated pyrochlore is known to exhibit a spin liquid, or cooperative paramagnetic state, at temperatures below ~ 20 K. Parametric studies of structural Bragg peaks appropriate to the Fd$\bar{3}$m space group of Tb2Ti2O7 reveal substantial broadening and peak intensity reduction in the temperature regime 20 K to 300 mK. We also observe a small, anomalous lattice expansion on cooling below a density maximum at ~ 18 K. These measurements are consistent with the development of fluctuations above a cooperative Jahn-Teller, cubic-tetragonal phase transition at very low temperatures.Comment: 5 pages, 4 figures, submitted for publicatio

Azacitidine for treating acute myeloid leukaemia with more than 30% bone marrow blasts: A Single Technology Appraisal

Report commissioned by the NIHR HTA ProgrammeThis report was commissioned by the NIHR HTA Programme as project number 15/64/10

A detailed determination of the a priori mixing angles in non-leptonic decays of hyperons

Non-leptonic Decays of Hyperons can provide a detailed determination of the a priori mixing angles that appear in physical hadrons in the approach in which non-perturbative flavor and parity violations are present in tiny pieces of the hadron mass operator. The determination of such angles in these decays will provide a bench mark to test their necessary universality-like property in other types of decays. Our main result is that the magnitudes of the a priori mixing angles can be determined quite accurately

Simplified projection on total spin zero for state preparation on quantum computers

We introduce a simple algorithm for projecting on J=0 states of a many-body system by performing a series of rotations to remove states with angular momentum projections greater than zero. Existing methods rely on unitary evolution with the two-body operator J2, which when expressed in the computational basis contains many complicated Pauli strings requiring Trotterization and leading to very deep quantum circuits. Our approach performs the necessary projections using the one-body operators Jx and Jz. By leveraging the method of Cartan decomposition, the unitary transformations that perform the projection can be parametrized as a product of a small number of two-qubit rotations, with angles determined by an efficient classical optimization. Given the reduced complexity in terms of gates, this approach can be used to prepare approximate ground states of even-even nuclei by projecting onto the J=0 component of deformed Hartree-Fock states. We estimate the resource requirements in terms of the universal gate set {H,S,CNOT,T} and briefly discuss a variant of the algorithm that projects onto J=1/2 states of a system with an odd number of fermions

Developments in the negative-U modelling of the cuprate HTSC systems

The paper deals with the many stands that go into creating the unique and complex nature of the HTSC cuprates above Tc as below. Like its predecessors it treats charge, not spin or lattice, as prime mover, but thus taken in the context of the chemical bonding relevant to these copper oxides. The crucial shell filling, negative-U, double-loading fluctuations possible there require accessing at high valent local environment as prevails within the mixed valent, inhomogeneous two sub-system circumstance of the HTSC materials. Close attention is paid to the recent results from Corson, Demsar, Li, Johnson, Norman, Varma, Gyorffy and colleagues.Comment: 44 pages:200+ references. Submitted to J.Phys.:Condensed Matter, Sept 7 200

Cystatin C: current position and future prospects.

Abstract Cystatin C is a low-molecular-weight protein which has been proposed as a marker of renal function that could replace creatinine. Indeed, the concentration of cystatin C is mainly determined by glomerular filtration and is particularly of interest in clinical settings where the relationship between creatinine production and muscle mass impairs the clinical performance of creatinine. Since the last decade, numerous studies have evaluated its potential use in measuring renal function in various populations. More recently, other potential developments for its clinical use have emerged. This review summarises current knowledge about the physiology of cystatin C and about its use as a renal marker, either alone or in equations developed to estimate the glomerular filtration rate. This paper also reviews recent data about the other applications of cystatin C, particularly in cardiology, oncology and clinical pharmacology. Clin Chem Lab Med 2008;46:1664-86

Pautas de consumo textil en una sociedad rural: Liébana (Cantabria), 1700-1860

Editada en la Fundación SEPISobre la base documental de los inventarios post mortem se estudia la evolución del consumo de textiles -ajuar doméstico y vestuario-- en una comarca rural de la actual Comunidad Autónoma de Cantabria. Se constata un aumento continuado en el stock de textiles entre 1750 y 1860, Y muy especialmente a lo largo de las cuatro primeras décadas del siglo XIX. Se entiende el consumo de textiles, también, como una forma de relacionarse, de comunicarse, de tal manera que las posibilidades de cambios en las pautas de consumo se fundamentan, a la vez que en factores económicos, en la existencia de transformaciones políticas, sociales y culturales.This article deals with the evolution of the consumption of textiles -domestic household and costumes- in a rural area in the region of Cantabria. The documental base is a series of post-mortem inventories. The authors verify a continuous rise of the textiles stock between 1750 and 1860, especialIy during the first four decades of the nineteenth century. The consumption of textiles also shows that trade is a form of social communication. No doubt, the possible changes in the consumption patterns come not only from economic factors, but also from political, social and cultural variations.Este número extraordinario de la Revista de Historia Económica ha sido posible gracias a una subvención de la Fundación Caja Madri

The European Hematology Association Roadmap for European Hematology Research: a consensus document

The European Hematology Association (EHA) Roadmap for European Hematology Research highlights major achievements in diagnosis and treatment of blood disorders and identifies the greatest unmet clinical and scientific needs in those areas to enable better funded, more focused European hematology research. Initiated by the EHA, around 300 experts contributed to the consensus document, which will help European policy makers, research funders, research organizations, researchers, and patient groups make better informed decisions on hematology research. It also aims to raise public awareness of the burden of blood disorders on European society, which purely in economic terms is estimated at €23 billion per year, a level of cost that is not matched in current European hematology research funding. In recent decades, hematology research has improved our fundamental understanding of the biology of blood disorders, and has improved diagnostics and treatments, sometimes in revolutionary ways. This progress highlights the potential of focused basic research programs such as this EHA Roadmap. The EHA Roadmap identifies nine ‘sections’ in hematology: normal hematopoiesis, malignant lymphoid and myeloid diseases, anemias and related diseases, platelet disorders, blood coagulation and hemostatic disorders, transfusion medicine, infections in hematology, and hematopoietic stem cell transplantation. These sections span 60 smaller groups of diseases or disorders. The EHA Roadmap identifies priorities and needs across the field of hematology, including those to develop targeted therapies based on genomic profiling and chemical biology, to eradicate minimal residual malignant disease, and to develop cellular immunotherapies, combination treatments, gene therapies, hematopoietic stem cell treatments, and treatments that are better tolerated by elderly patients

Magnetism and Fermiology of Kagome Magnet YMn6Sn4Ge2

Kagome lattice magnets are an interesting class of materials as they can host topological properties in their magnetic and electronic structures. YMn6Sn6 is one such compound in which a series of competing magnetic phases is stabilized by an applied magnetic field, and both an enigmatic topological Hall effect and a Dirac crossing close to the Fermi energy have been realized. This material also shows a magnetization-induced Lifshitz transition and evidence of a unique charge spin coupling in one of the magnetic phases, namely the fan-like phase. Tuning the magnetism, and thus the interplay with the electronic states, opens new avenues for precise control of these novel properties. Here, we demonstrate the extreme sensitivity of the magnetic phases in YMn6Sn4Ge2 through the investigation of structural, magnetic, and transport properties. The high sensitivity to small doping provides great potential for engineering the magnetic phases and associated electronic properties in this family of rare-earth kagome magnets