Discovery to Development: Insecticides for Malaria Vector Control

This report provides an outline of a program for the discovery of new public health insecticides for malaria vector control. The status of malaria vector control is first reviewed in terms of the chemical, physical chemical, and biochemical properties of the current WHOPES-recommended and approved vector control agents. This review provides a basis for a discussion on the critical need for discovery and development of multiple new chemical malaria vector control agents with novel and diverse modes of action. The Innovative Vector Control Consortium (IVCC) New Active Ingredient Target Product Profile (TPP) describes the essential attributes for a successful new malaria vector control agent and then serves as the basis for development of a discovery cascade. The cascade addresses these attributes experimentally at each stage of the discovery process – from design and assembly of an appropriate collection of chemicals for screening, through development of testing protocols to sort candidates, and into the detailed profiling of advanced pre-development candidates against TPP requirements. In addition, this program defines a staged development system to provide intermediate guidance to the insecticide explorer regarding the progress of their discovery program against the ultimate product goal

A cost effectiveness study of integrated care in health services delivery: a diabetes program in Australia

Background: Type 2 diabetes is rapidly growing as a proportion of the disease burden in Australia as elsewhere. This study addresses the cost effectiveness of an integrated approach to assisting general practitioners (GPs) with diabetes management. This approach uses a centralized database of clinical data of an Australian Division of General Practice (a network of GPs) to co-ordinate care according to national guidelines. Methods: Long term outcomes for patients in the program were derived using clinical parameters after 5 years of program participation, and the United Kingdom Prospective Diabetes Study (UKPDS) Outcomes Model, to project outcomes for 40 years from the time of diagnosis and from 5 years post-diagnosis. Cost information was obtained from a range of sources. While program costs are directly available, and costs of complications can be estimated from the UKPDS model, other costs are estimated by comparing costs in the Division with average costs across the state or the nation. The outcome and cost measures are used derive incremental cost-effectiveness ratios. Results: The clinical data show that the program is effective in the short term, with improvement or no statistical difference in most clinical measures over 5 years. Average HbA1c levels increased by less than expected over the 5 year period. While the program is estimated to generate treatment cost savings, overall net costs are positive. However, the program led to projected improvements in expected life years and Quality Adjusted Life Expectancy (QALE), with incremental cost effectiveness ratios of $A8,106 per life-year saved and$A9,730 per year of QALE gained. Conclusions: The combination of an established model of diabetes progression and generally available data has provided an opportunity to establish robust methods of testing the cost effectiveness of a program for which a formal control group was not available. Based on this methodology, integrated health care delivery provided by a network of GPs improved health outcomes of type 2 diabetics with acceptable cost effectiveness, which suggests that similar outcomes may be obtained elsewhere

Beneath Brooklyn’s Darkened Skies, Court Continues Long Into the Night

Tens of thousands of people who pass annually through New York’s criminal justice system via night court in Brooklyn. In these eight hours, the administration of justice slows and the human foundation of this bureaucracy is on display as the court works into the night. http://www.emilieruscoe.com/night-court

A cost effectiveness study of integrated care in health services delivery: a diabetes program in Australia

BACKGROUND: Type 2 diabetes is rapidly growing as a proportion of the disease burden in Australia as elsewhere. This study addresses the cost effectiveness of an integrated approach to assisting general practitioners (GPs) with diabetes management. This approach uses a centralized database of clinical data of an Australian Division of General Practice (a network of GPs) to co-ordinate care according to national guidelines. METHODS: Long term outcomes for patients in the program were derived using clinical parameters after 5 years of program participation, and the United Kingdom Prospective Diabetes Study (UKPDS) Outcomes Model, to project outcomes for 40 years from the time of diagnosis and from 5 years postdiagnosis. Cost information was obtained from a range of sources. While program costs are directly available, and costs of complications can be estimated from the UKPDS model, other costs are estimated by comparing costs in the Division with average costs across the state or the nation. The outcome and cost measures are used derive incremental cost-effectiveness ratios. RESULTS: The clinical data show that the program is effective in the short term, with improvement or no statistical difference in most clinical measures over 5 years. Average HbA1c levels increased by less than expected over the 5 year period. While the program is estimated to generate treatment cost savings, overall net costs are positive. However, the program led to projected improvements in expected life years and Quality Adjusted Life Expectancy (QALE), with incremental cost effectiveness ratios of $A8,106 per life-year saved and$A9,730 per year of QALE gained. CONCLUSIONS: The combination of an established model of diabetes progression and generally available data has provided an opportunity to establish robust methods of testing the cost effectiveness of a program for which a formal control group was not available. Based on this methodology, integrated health care delivery provided by a network of GPs improved health outcomes of type 2 diabetics with acceptable cost effectiveness, which suggests that similar outcomes may be obtained elsewhere

Pre-adulthood developmental psycho-social influences behind women becoming engineers in contemporary Australia

This study explored the pre-adulthood development of female engineers with a focus on influences behind their career choice. Pre-adulthood encompasses the ages 0. to 23 and includes all development prior to settling on a career (Levinson, Darrow, Klein, Levinson, & McKee, 1979). ,This area of study derives its importance from the continuing low proportion of women in engineering (9.6%; Kaspura, 2009), the gender bias that this may indicate (Burke & Mattis, 2007), and the benefits of increasing the number of women• in engineering (Engineers Australia, 20 I 0). A phenomenological methodology was applied, utilising semi-structured interviews with 10 female graduate, engineers aged 22 to 25 who had completed primary, secondary, and tertiary education ih Australia. Content analysis revealed several potential influences behind career choice for these women, some of which do not appear in the literature. Potential influences included playing with Lego and blocks in childhood, gender bias from students at school and university, compatibility with perceived male culture, female nerd status at school, a male propensity to swear more than females interfering with facilitative male-female relationships, and anticipated lack of family-flexibility in engineering careers. These potential influences on career choice may highlight aspects of pre-adulthood and engineering in Australia that warrant further investigation and may be useful for increasing the proportion of women in engineering and reducing gender bia

Agricultural impacts on plant beneficial pseudomonads

The soil microbiome is a dynamic and complex environment that offers numerous ecosystem services. Beneficial Pseudomonas spp. are agriculturally relevant bacteria with a plethora of plant growth promoting (PGP) traits, making them desirable targets for microbial inoculant development. Microbial inoculants have typically failed to produce reliable results, which can be attributed to the introduction of microbes into ecologically unsuitable environments. Its therefore important to better understand factors that can alter Pseudomonas spp. community structure and functioning. Crop domestication and land management have both played important roles in the development of agriculture over the last 10,000 years, however they have been associated with negative impacts on the soil microbiome. Here, the impacts of these agricultural components on soil pseudomonads was investigated. The study of 17 domesticated and ancestral wheat genotypes cultivated in a grassland soil revealed no clear difference in pseudomonad community structure within rhizosphere or bulk soil. The Highfield experiment at Rothamsted Research tests the impact of land management and revealed various impacts to soil properties, wheat physiology and total microbial abundance across grassland, arable and bare fallow managed soils. However, pseudomonad abundance was not found to significantly differ in bulk soil and rhizosphere communities. Additional studies looking at the more closely associated root compartment of wheat grown in soils from distinct land uses, revealed differences in abundance and phylogeny of cultivated pseudomonads. A range of PGP genetic and functional potentials including siderophore production, anti-fungal activity and phosphate solubilisation differed in isolates according to land use. The presence of the 1-Aminocyclopropane-1-carboxylate (ACC) deaminase gene (acdS) was of particular interest, due to its potential to reduce levels of stress ethylene in plants by degrading its precursor ACC. Intriguingly, acdS gene abundance, phylogeny and functional activity appeared to differ in pseudomonads associated with the different land uses. The rhizosphere and root compartments of wheat had a higher acdS gene abundance, particularly in the bare fallow soil which is known to have degraded soil properties. This suggests factors associated with wheat grown in different land managements were driving the selection of ACC deaminase producing pseudomonads. In vitro attempts to promote wheat growth under salt stress by applying ACC deaminase-containing isolates was not successful. Overall this thesis evidences the functional potential of pseudomonads for use in microbial inoculants, whilst providing an insight into the complexity of soil-plant-microbe interactions

Responding to children’s voices: The new frontier in education policy reform

More than thirty years on from the United Nations Convention of the Child honouring a child’s right to be heard (Article 12) has unlocked a new frontier in ethical research. In education, children have demonstrated competence to contribute with insight to recent policy development in Australia. This paper provides further evidence of the critical role children stand to play in education reform. A post-structural perspective is adopted and underpinned with Foucauldian theory of discursive power in the context of school-based affordances. Visual and dialogic qualitative methods are used to compare the impact of powerful discourses upon children’s affordances in the first year of compulsory school. Three overarching theses drawn from children’s perspectives are summarised; disparity between adult and child expectations of school, adult influence upon children’s perceptions of school, and children’s power to sustain or disrupt a discourse through dis/engagement. The findings illustrate an urgent need for systematic consult with children on issues relevant to them and calls for a public platform for amplifying their unique views to policy makers for response

Prying the Bond that Ties; Breaking Variations in Nuclear Capabilities from Changes in Strategic Stability

Do variations in state nuclear capabilities drive changes in strategic stability? The importance of strategic stability’s causal relationship with nuclear capabilities is impossible to overstate, given the bulk of Cold War scholarship. Viewed broadly, strategic stability is the degree of mutual deterrence from war between potential adversaries. Since the close of World War II, tomes of research from scholars and practitioners alike have frequently coupled variations in nuclear capabilities with changes in strategic stability, treating the two conditions as if they existed in a mutually dependent relationship. The results of the present research show that this unconditional causal relationship does not exist. To determine the existence of the tight coupling of nuclear capabilities with strategic stability that scholarship has suggested, the present research examines case studies in which strategic stability changed in a dyadic state system where both sides had nuclear capabilities. Early in the Cold War, any changes in nuclear capabilities should have driven changes in strategic stability as the United States and Soviet Union fought to develop and field ever larger atomic arsenals. Throughout the 1950s and for most of the 1960s, the United States constructed atomic dominance, which afforded the government an opportunity to obtain strategic stability by denying the Soviet Union the ability to strike back if hit first. However, the Soviet Union built more significant nuclear capabilities and, in the late 1960s, American dominance waned. This enabled each side to achieve second-strike capabilities, breaking the capability–stability causal relationship. The case studies reported as part of this research detail events that occurred between 1957 and 1967, centered on the 1962 Cuban missile crisis, a time when the causal relationship between nuclear capabilities and strategic stability should have been at its strongest. Viewed from the perspective of escalation theory, changes in strategic stability represent both positive and negative adjustments in dyadic state relations relative to dyadic state war. The results of this research apply to all existing nuclear dyads, making early Cold War dyadic state relationships relevant in the here and now. Advancing my claim further, any time that technological innovations of war have the potential to cause dyadic state strategic instability, this research shows that the causal factors of dyadic states driving toward and away from war will remain varied and not reliant on any singular weapon or capability. Through the examination of these cases, I present the argument that nuclear capabilities are sometimes sufficient to cause changes in strategic stability, but are not a necessary component