The early expansion and evolutionary dynamics of POU class genes.

The POU genes represent a diverse class of animal-specific transcription factors that play important roles in neurogenesis, pluripotency, and cell-type specification. Although previous attempts have been made to reconstruct the evolution of the POU class, these studies have been limited by a small number of representative taxa, and a lack of sequences from basally branching organisms. In this study, we performed comparative analyses on available genomes and sequences recovered through "gene fishing" to better resolve the topology of the POU gene tree. We then used ancestral state reconstruction to map the most likely changes in amino acid evolution for the conserved domains. Our work suggests that four of the six POU families evolved before the last common ancestor of living animals-doubling previous estimates-and were followed by extensive clade-specific gene loss. Amino acid changes are distributed unequally across the gene tree, consistent with a neofunctionalization model of protein evolution. We consider our results in the context of early animal evolution, and the role of POU5 genes in maintaining stem cell pluripotency

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Pregnancy outcome following prenatal diagnosis of chromosomal anomaly: a record linkage study of 26,261 pregnancies

Previous studies have demonstrated the influence of changes in the age at which women give birth, and of developments in prenatal screening and diagnosis on the number of pregnancies diagnosed and terminated with chromosomal anomalies. However, we are unaware of any population studies examining pregnancy terminations after diagnosis of chromosomal anomalies that has included all aneuploidies and the influence of maternal factors. The aims of this study were to examine the association between results of prenatal tests and pregnancy termination, and the proportion of foetuses with and without chromosomal anomalies referred for invasive diagnostic tests over time. Diagnostic information of 26,261 prenatal invasive tests from all genetic service laboratories in Scotland from 2000 to 2011 was linked to Scottish Morbidity Records to obtain details on pregnancy outcome. Binary logistic regression was carried out to test the associations of year and type of diagnosis with pregnancy termination, while controlling for maternal age, neighbourhood deprivation and parity. There were 24,155 (92.0%) with no chromosomal anomalies, 1,483 (5.6%) aneuploidy diagnoses, and 623 (2.4%) diagnoses of anomaly that was not aneuploidy (including translocations and single chromosome deletions). In comparison with negative test results, pregnancies diagnosed with trisomy were most likely to be terminated (adjusted OR 437.40, 95% CI 348.19–549.46) followed by other aneuploid anomalies (adjusted OR 95.94, 95% CI 69.21–133.01). During the study period, fewer pregnancies that were diagnosed with aneuploidy were terminated, including trisomy diagnoses (adjusted OR 0.44, 95% CI 0.26–0.73). Older women were less likely to terminate (OR 0.35, 95% CI 0.28, 0.42), and parity was also an independent predictor of termination. In keeping with previous findings, while the number of invasive diagnostic tests declined, the proportion of abnormal results increased from 6.09% to 10.88%. Systematic advances in prenatal screening have improved detection rates for aneuploidy. This has been accompanied by a reduction in the rate of termination for aneuploidy. This may reflect societal changes with acceptance of greater diversity, but this is speculation, and further research would be needed to test this

Parents' involvement in child care: do parental and work identities matter?

The current study draws on identity theory to explore mothers' and fathers' involvement in childcare. It examined the relationships between the salience and centrality of individuals’ parental and work-related identities and the extent to which they are involved in various forms of childcare. A sample of 148 couples with at least one child aged 6 years or younger completed extensive questionnaires. As hypothesized, the salience and centrality of parental identities were positively related to mothers' and fathers' involvement in childcare. Moreover, maternal identity salience was negatively related to fathers' hours of childcare and share of childcare tasks. Finally, work hours mediated the negative relationships between the centrality of work identities and time invested in childcare, and gender moderated this mediation effect. That is, the more central a mother's work identity, the more hours she worked for pay and the fewer hours she invested in childcare. These findings shed light on the role of parental identities in guiding behavioral choices, and attest to the importance of distinguishing between identity salience and centrality as two components of self-structure

Interview with Ruth Jacobs

Discusses husband\u27s notebook, Orville Wright, wind tunnels, restoration of Wright plane, poor US reception, Kettering, Deeds, Orville\u27s car, Brewer, Smithsonian, Langley, G. Curtiss, and Paul L. Dunbar

Uncorking the Mommy Market: Phenomenal Facebook following has Marilé Borden contemplating the future of Moms Who Need Wine

Marilé Borden ’94 has hundreds of thousands of people watching her Facebook page Moms Who Need Wine. Now what to do with them

David Greene Is Called to Action

Not long after the Board of Trustees named David A. Greene Colby\u27s 20th president, in September 2013, word spread that Greene wanted to increase the number of applicants- by a lot. Doubling applications, which he suggested, would be a dramatic shift for a college that typically sees single-digit growth in applications. The University of Chicago, where Greene recently served as executive vice president, has tripled its number of applicants since Greene\u27s (and President Robert Zimmer\u27s) arrival in 2006, resulting in a more diverse student body by key measures- socioeconomic, racial, ethnic, and geographic. It has also soared in the rankings, from 15 to number five in U.S. News & World Report (under only Princeton, Harvard, Yale, and Columbia), created three major institutes, and opened two academic centers in Asia. Could growth like this be possible for Colby with this new president at the helm? By all accounts, yes. Greene\u27s record shows that he doesn\u27t just talk big. He does big

The Navigator: Philip Nyhus directs the Chinese government to the places where tigers may once again roam free

When the government of China decided to explore reintroducing the South China tiger to the wild, Assistant Professor Philip Nyhus (environmental studies) got the call. Now Nyhus and Colby students use state-of-the-art Geographic Information System (GIS) technology to evaluate potential tiger habitat

Class Action: Homeless in high school, Jessica Boyle fought to make Colby a place where students from all backgrounds can thrive

Once a homeless teen, Jessica Boyle ’12 worked to make Colby a place where students like her can thrive

A second grade arithmetic experience unit with systematic practices and tests

Thesis (Ed.M.)--Boston Universit