Long transients and cluster size in globally coupled maps

We analyze the asymptotic states in the partially ordered phase of a system of globally coupled logistic maps. We confirm that, regardless of initial conditions, these states consist of a few clusters, and they properly belong in the ordered phase of these systems. The transient times necessary to reach the asymptotic states can be very long, especially very near the transition line separating the ordered and the coherent phases. We find that, where two clusters form, the distribution of their sizes corresponds to windows of regular or narrow-band chaotic behavior in the bifurcation diagram of a system of two degrees of freedom that describes the motion of two clusters, where the size of one cluster acts as a bifurcation parameter.Comment: To appear in Europhysics Letter

Trapping Dynamics with Gated Traps: Stochastic Resonance-Like Phenomenon

We present a simple one-dimensional trapping model prompted by the problem of ion current across biological membranes. The trap is modeled mimicking the ionic channel membrane behaviour. Such voltage-sensitive channels are open or closed depending on the value taken by a potential. Here we have assumed that the external potential has two contributions: a determinist periodic and a stochastic one. Our model shows a resonant-like maximum when we plot the amplitude of the oscillations in the absorption current vs. noise intensity. The model was solved both numerically and using an analytic approximation and was found to be in good accord with numerical simulations.Comment: RevTex, 5 pgs, 3 figure

F0, EMG and Tonogensis in Thai

This paper, based on examination of initial F0 of bilabial stops in Standard Thai, reports that pre-voiced bilabial stops (negative VOT) have lower initial F0 than the voiceless (approximately 0ms VOT) or voiceless aspirated stops (those with positive VOT). Also reported in this paper are measurements from electromyographic (EMG) laryngeal muscle activity (cricothyroid and strap muscles) associated with the initial F0 of the bilabial stops. The F0 and EMG data are discussed in terms of historical theories of tonogenesis for Thai. The F0 data support the hypothesis of tonogenesis as put forth by historical linguists; however, a connection between the laryngeal muscles examined and the high/low intrinsic F0 of the bilabial stops was not found. Additional acoustic, aerodynamic and laryngeal research is needed in order to understand the interaction between initial stops and the development of tones

Fluid physics, thermodynamics, and heat transfer experiments in space

An overstudy committee was formed to study and recommend fundamental experiments in fluid physics, thermodynamics, and heat transfer for experimentation in orbit, using the space shuttle system and a space laboratory. The space environment, particularly the low-gravity condition, is an indispensable requirement for all the recommended experiments. The experiments fell broadly into five groups: critical-point thermophysical phenomena, fluid surface dynamics and capillarity, convection at reduced gravity, non-heated multiphase mixtures, and multiphase heat transfer. The Committee attempted to assess the effects of g-jitter and other perturbations of the gravitational field on the conduct of the experiments. A series of ground-based experiments are recommended to define some of the phenomena and to develop reliable instrumentation

Targeting colorectal cancer via its microenvironment by inhibiting IGF-1 receptor-insulin receptor substrate and STAT3 signaling.

The tumor microenvironment (TME) exerts critical pro-tumorigenic effects through cytokines and growth factors that support cancer cell proliferation, survival, motility and invasion. Insulin-like growth factor-1 (IGF-1) and signal transducer and activator of transcription 3 (STAT3) stimulate colorectal cancer development and progression via cell autonomous and microenvironmental effects. Using a unique inhibitor, NT157, which targets both IGF-1 receptor (IGF-1R) and STAT3, we show that these pathways regulate many TME functions associated with sporadic colonic tumorigenesis in CPC-APC mice, in which cancer development is driven by loss of the Apc tumor suppressor gene. NT157 causes a substantial reduction in tumor burden by affecting cancer cells, cancer-associated fibroblasts (CAF) and myeloid cells. Decreased cancer cell proliferation and increased apoptosis were accompanied by inhibition of CAF activation and decreased inflammation. Furthermore, NT157 inhibited expression of pro-tumorigenic cytokines, chemokines and growth factors, including IL-6, IL-11 and IL-23 as well as CCL2, CCL5, CXCL7, CXCL5, ICAM1 and TGFβ; decreased cancer cell migratory activity and reduced their proliferation in the liver. NT157 represents a new class of anti-cancer drugs that affect both the malignant cell and its supportive microenvironment

The Dependence of Galaxy Shape on Luminosity and Surface Brightness Profile

For a sample of 96,951 galaxies from the Sloan Digital Sky Survey Data Release 3, we study the distribution of apparent axis ratios as a function of r-band absolute magnitude and surface brightness profile type. We use the parameter fracDeV to quantify the profile type (fracDeV = 1 for a de Vaucouleurs profile; fracDeV = 0 for an exponential profile). When the apparent axis ratio q_{am} is estimated from the moments of the light distribution, the roundest galaxies are very bright (M_r \sim -23) de Vaucouleurs galaxies and the flattest are modestly bright (M_r \sim -18) exponential galaxies. When the apparent axis ratio q_{25} is estimated from the axis ratio of the 25 mag/arcsec^2 isophote, we find that de Vaucouleurs galaxies are flatter than exponential galaxies of the same absolute magnitude. For a given surface brightness profile type, very bright galaxies are rounder, on average, than fainter galaxies. We deconvolve the distributions of apparent axis ratios to find the distribution of the intrinsic short-to-long axis ratio gamma, assuming constant triaxiality T. For all profile types and luminosities, the distribution of apparent axis ratios is inconsistent with a population of oblate spheroids, but is usually consistent with a population of prolate spheroids. Bright galaxies with a de Vaucouleurs profile (M_r < -21.84, fracDeV > 0.9) have a distribution of q_{am} that is consistent with triaxiality in the range 0.4 < T < 0.8, with mean intrinsic axis ratio 0.66 < gamma < 0.69. The fainter de Vaucouleurs galaxies are best fit with prolate spheroids (T = 1) with mean axis ratio gamma = 0.51.Comment: 32 pages, 12 figures, to appear in Ap

The dynamics of opinion in hierarchical organizations

We study the mutual influence of authority and persuasion in the flow of opinion. Many social organizations are characterized by a hierarchical structure where the propagation of opinion is asymmetric. In the normal flow of opinion formation a high-rank agent uses its authority (or its persuasion when necessary) to impose its opinion on others. However, agents with no authority may only use the force of its persuasion to propagate their opinions. In this contribution we describe a simple model with no social mobility, where each agent belongs to a class in the hierarchy and has also a persuasion capability. The model is studied numerically for a three levels case, and analytically within a mean field approximation, with a very good agreement between the two approaches. The stratum where the dominant opinion arises from is strongly dependent on the percentage of agents in each hierarchy level, and we obtain a phase diagram identifying the relative frequency of prevailing opinions. We also find that the time evolution of the conflicting opinions polarizes after a short transient.Comment: 6 pages, 5 figures, submitted to Phys. Rev.