Exploring virtual reality in construction, visualization and building performance analysis

In the past two decades, the Architecture, Engineering and Construction (AEC) industry has investigated different approaches to improve communication among project parties, including Virtual reality (VR) however these approaches have not been widely adopted by the industry. Today, the tremendous advancements in technologies and computer hardware have potentially improved the current approaches and enabled a significant enhancement of user experience of Virtual reality (VR) devices. Based on that the researchers have conducted a review to investigate the global VR applications research in (AEC) community in 2015- 2017 to understand the status and the trend of immersive virtual reality (IVR) research in the world using these affordable devices. This paper also presents a result of an experiment to integrate three different types of AEC digital modeling data and proposed workflows for IVR applications in construction, visualization and building performance analysis. The experiment deals with construction simulation, rapid generation of the VR scene for existing building and airflow visualization. Several workflows investigated game engine and VR tools have been use

Imprinting disorders: a group of congenital disorders with overlapping patterns of molecular changes affecting imprinted loci.

Congenital imprinting disorders (IDs) are characterised by molecular changes affecting imprinted chromosomal regions and genes, i.e. genes that are expressed in a parent-of-origin specific manner. Recent years have seen a great expansion in the range of alterations in regulation, dosage or DNA sequence shown to disturb imprinted gene expression, and the correspondingly broad range of resultant clinical syndromes. At the same time, however, it has become clear that this diversity of IDs has common underlying principles, not only in shared molecular mechanisms, but also in interrelated clinical impacts upon growth, development and metabolism. Thus, detailed and systematic analysis of IDs can not only identify unifying principles of molecular epigenetics in health and disease, but also support personalisation of diagnosis and management for individual patients and families.All authors are members of the EUCID.net network, funded by COST (BM1208). TE is funded by the German Ministry of research and education (01GM1513B). GPdN is funded by I3SNS Program of the Spanish Ministry of Health (CP03/0064; SIVI 1395/09), Instituto de Salud Carlos III (PI13/00467) and Basque Department of Health (GV2014/111017).This is the final version of the article. It first appeared from BioMed Central via http://dx.doi.org/10.1186/s13148-015-0143-

The development of a digitally enhanced visual inspection framework for masonry bridges in the UK

Purpose: The utilisation of emerging technologies for the inspection of bridges has remarkably increased. In particular, non-destructive testing (NDT) technologies are deemed a potential alternative for costly, labour-intensive, subjective and unsafe conventional bridge inspection regimes. This paper aims to develop a framework to overcome conventional inspection regimes' limitations by deploying multiple NDT technologies to carry out digital visual inspections of masonry railway bridges. Design/methodology/approach: This research adopts an exploratory case study approach, and the empirical data is collected through exploratory workshops, interviews and document reviews. The framework is implemented and refined in five masonry bridges as part of the UK railway infrastructure. Four NDT technologies, namely, terrestrial laser scanner, infrared thermography, 360-degree imaging and unmanned aerial vehicles, are used in this study. Findings: A digitally enhanced visual inspection framework is developed by using complementary optical methods. Compared to the conventional inspection regimes, the new approach requires fewer subjective interpretations due to the additional qualitative and quantitative analysis. Also, it is safer and needs fewer operators on site, as the actual inspection can be carried out remotely. Originality/value: This research is a step towards digitalising the inspection of bridges, and it is of particular interest to transport agencies and bridge inspectors and can potentially result in revolutionising the bridge inspection regimes and guidelines

Development of Mountain Climate Generator and Snowpack model for Erosion Predictions in the Western United States using WEPP, Reserach Completion Report for Phase II

Executive Summary: This report summarizes work conducted during the funding period (July 1 through September 30, 1990) of a Cooperative Agreement between the United States Forest Service (USFS) and the Utah Water Research Laboratory (UWRL), Utah State University. The purpose of the agreement is to develop a Western Mountain Climate Generator (MCLIGEN) similar in function to the existing Climate Generator (CLIGEN), which is part of the Water Erosion Prediction Project (WEPP) procedure. Also, we are developing a Western U.S. snowpack simulation model for inclusion in WEPP. In the Western U.S., few meteorological observations exist in high elecation areas where Forest Service properties are located. Therefore, a procedure for estimating climatological variables in mountainous areas is needed to apply WEPP in these regions. A physically-based approach, using an expanded and improved orographic precipitation model, is being utilized. It will use radiosonde data and also lighning data to simualte convective storms. Climatological sequences thus estimated at ungaged locatiosn will be represented using stochastic models, similar to the approach used in the existing CLIGEN, and their parameters will be available to users through maps. By using these stochastic models, WEPP usters can synthsize climate sequences for input to WEPP. During the reporting period we have implemented the the Rhea orographic precipitation model and begun preliminary model testing in two regions. Also, we have begun formulation of model modifications for handling convective events. Various snowplack and meteorological data sets have been acquired and others have been ordered. Some of these have been applied in ititial applications of several snowpack models which have been recorded in a modeular form. Work has commenced on the statistical analysis of western climate sequences, including the preliminary assessment of the alternative stochastic model structures. Additional review of literature has been commenced for establishing desing storms and design hydrographs for events of various return periods in mountainous regions. Accomplishments are summarized in three parts: 1) climatological process models, 2) snowpack simulation models, and 3) stochastic models of climatological variablse and parameter regionalization. A chapter of the report is devoted to each of these three parts

Development of Mountain Climate Generator and Snowpack model for Erosion Predictions in the Western United States Using WEPP, Progress Report No. 1

Executive Summary: This report summarizes work conducted during the initial funding period (November 1, 1989 through June 30, 1990) of a Cooperative Agreement between the United States Forest Service (USFS) and the Utah Water Research Laboratory (UWRL), Utah State University. The purpose of the agreement is to develop a procedure for incorporating western mountain climate into the existing Climate Generator (CLIGEN), which is part of the Water Erosion Prediction Project (WEPP) procedure. In the Western U.S., few meteorological observations exist in high elevation areas where Forest Service properties are located. Therefore, a procedure for estimating climatological variables in mountainous areas is needed to apply WEPP in these regions. A physically-based approach, an expanded and improved orographic precipitation model, is proposed in this report. It will use radiosonde data and also lightning data to simulate convective storms. Climatological sequences thus estimated at ungaged locations will be represented using stochastic models, similar to the approach used in the existing CLIGEN, and their parameters will be available to users through maps. By using these stochastic models, WEPP users can synthesize climate sequences for input to WEPP. Several alternative approaches to developing the Mountain Climate Generator (MCLIGEN) have been formulated and evaluated. These options vary in their spatial resolution. Some will provide synthetic climate inputs whereas others will provide synthetic sequences of water delivery to the ground surface or overland flow delivery. The latter will reduce the user\u27s responsibility for judging adequate snowpack or hydrological simulations, but will enormously increase the effort required for parameterization during the developmental phase. Based on our evaluation, we recommend that Option 2 for generating fine scale climate sequences be adopted. This option appears to satisfy the WEPP spatial resolution requirements of the USFS and requires a reasonable level of developmental effort. We also recommend that Option 3 be available to the users. We recomment that under this option snowpack initial conditions at a specified date be available based on a return period or exceedance probability. Under this option discontinuous simulation periods could be considered. The data, models, and parameters needed to implement the recommended approach can be divided into three parts: 1) climatological process models, 2) a snowpack imulation model, and 3) stochastic models of climatological variables and parameter regionalization. A chapter of the report is devoted to each of these three parts. Each chapter includes a literature review and a description of the proposed methodology and work plan for its development. We further recommend that a comprehensive plan for data collection for validation of the entire WEPP methodology applied to the mountainous Western U.S. be developed. Also, we propose that UWRL take the lead in settin gup a user group for orographic precipitation modelers

A multi-scale analysis of bull sperm methylome revealed both species peculiarities and conserved tissue-specific

peer-reviewedBackground: Spermatozoa have a remarkable epigenome in line with their degree of specialization, their unique nature and different requirements for successful fertilization. Accordingly, perturbations in the establishment of DNA methylation patterns during male germ cell differentiation have been associated with infertility in several species.Background: Spermatozoa have a remarkable epigenResults: The quantification of DNA methylation at CCGG sites using luminometric methylation assay (LUMA) highlighted the undermethylation of bull sperm compared to the sperm of rams, stallions, mice, goats and men. Total blood cells displayed a similarly high level of methylation in bulls and rams, suggesting that undermethylation of the bovine genome was specific to sperm. Annotation of CCGG sites in different species revealed no striking bias in the distribution of genome features targeted by LUMA that could explain undermethylation of bull sperm. To map DNA methylation at a genome-wide scale, bull sperm was compared with bovine liver, fibroblasts and monocytes using reduced representation bisulfite sequencing (RRBS) and immunoprecipitation of methylated DNA followed by microarray hybridization (MeDIP-chip). These two methods exhibited differences in terms of genome coverage, and consistently, two independent sets of sequences differentially methylated in sperm and somatic cells were identified for RRBS and MeDIP-chip. Remarkably, in the two sets most of the differentially methylated sequences were hypomethylated in sperm. In agreement with previous studies in other species, the sequences that were specifically hypomethylated in bull sperm targeted processes relevant to the germline differentiation program (piRNA metabolism, meiosis, spermatogenesis) and sperm functions (cell adhesion, fertilization), as well as satellites and rDNA repeats. Conclusions: These results highlight the undermethylation of bull spermatozoa when compared with both bovine somatic cells and the sperm of other mammals, and raise questions regarding the dynamics of DNA methylation in bovine male germline. Whether sperm undermethylation has potential interactions with structural variation in the cattle genome may deserve further attention. While bull semen is widely used in artificial insemination, the literature describing DNA methylation in bull spermatozoa is still scarce. The purpose of this study was therefore to characterize the bull sperm methylome relative to both bovine somatic cells and the sperm of other mammals through a multiscale analysis

Evaluation of Uterine Temperament in Iranian Infertile Women using a Quantitative Instrument for Uterine Temperament Detection

Background: The temperament is a basic concept of maintaining health in Traditional Persian Medicine. The two main grouping of temperament is hot/cold and wet/dry. Many female disorders include infertilities are diagnosed and treated based on the dystemperament therapies. This report describes design of a questionnaire for uterine temperament detection and its use to evaluate the uterine temperament of a population of infertile women. Methods: The uterine temperament parameters derived from main textbooks were used to design a questionnaire which its validity and reliability was proven by statistical methods. The questionnaire was then used to detect the uterine temperament of 54 infertile females. Also full history and physical exam and vaginal sonography was performed in the 3rd day of the menstrual cycle for all study participants. Results: The mean age was 30.92 +/- 5.53 years old. Mean uterine temperament score was 3.21 +/- 0.53 for hotness and 4.28 +/- 1 for wetness. Mean general body temperament was 138.88 +/- 17.61. The general body temperament hotness/coldness was significantly correlated with the uterus hotness/coldness (r = 0.0842); while the wetness/dryness temperament of the body and uterus were not correlated. Moreover, uterus temperament was not correlated with the size of the uterus and ovaries in sonography, but pelvic width was correlated with hot uterine temperament (r = 0.354, P = 0.0145). Conclusions: In the present study, the most prevalent achieved temperament was cold and wet in patients with infertility complaint. Moreover, the hot/cold temperament of body and pelvic width were correlated with uterus temperament. This may propose new prevention and also treatment methods in the field of infertility, which needs to be further evaluated

Laminectomy versus interlaminar approach for Lumbar disc herniation

Background: Low back pain is the most common health problem in men and women between the ages of 20 and 50 years. The lumbar disc prolapse has a major role in this condition. Treatment is either conservative or surgical. The most common surgical interventions are either laminectomy or interlaminar approach. Objective: To determine which is the best surgical approach for the patient according to his/her type of disc herniation. Patients and methods: A comparative clinical study conducted in the Neurosciences Hospital, Baghdad, Iraq from January 2016 to January 2018. In this paper we evaluated the clinical outcome following both approaches Results: We studied sixty cases; thirty-four patients had interlaminar approach for lumbar discectomy while twenty-six patients had laminectomy with discectomy. Conclusion: Both methods can manage different types of lumbar disc prolapse, apart from far-lateral disc which favors laminectomy approach