870 research outputs found
Tuning supersymmetric models at the LHC: A comparative analysis at two-loop level
We provide a comparative study of the fine tuning amount (Delta) at the
two-loop leading log level in supersymmetric models commonly used in SUSY
searches at the LHC. These are the constrained MSSM (CMSSM), non-universal
Higgs masses models (NUHM1, NUHM2), non-universal gaugino masses model (NUGM)
and GUT related gaugino masses models (NUGMd). Two definitions of the fine
tuning are used, the first (Delta_{max}) measures maximal fine-tuning wrt
individual parameters while the second (Delta_q) adds their contribution in
"quadrature". As a direct result of two theoretical constraints (the EW minimum
conditions), fine tuning (Delta_q) emerges as a suppressing factor (effective
prior) of the averaged likelihood (under the priors), under the integral of the
global probability of measuring the data (Bayesian evidence p(D)). For each
model, there is little difference between Delta_q, Delta_{max} in the region
allowed by the data, with similar behaviour as functions of the Higgs, gluino,
stop mass or SUSY scale (m_{susy}=(m_{\tilde t_1} m_{\tilde t_2})^{1/2}) or
dark matter and g-2 constraints. The analysis has the advantage that by
replacing any of these mass scales or constraints by their latest bounds one
easily infers for each model the value of Delta_q, Delta_{max} or vice versa.
For all models, minimal fine tuning is achieved for M_{higgs} near 115 GeV with
a Delta_q\approx Delta_{max}\approx 10 to 100 depending on the model, and in
the CMSSM this is actually a global minimum. Due to a strong (
exponential) dependence of Delta on M_{higgs}, for a Higgs mass near 125 GeV,
the above values of Delta_q\approx Delta_{max} increase to between 500 and
1000. Possible corrections to these values are briefly discussed.Comment: 23 pages, 46 figures; references added; some clarifications (section
2
Subcellular fractionation method to study endosomal trafficking of Kaposi’s sarcoma-associated herpesvirus
Background
Virus entry involves multiple steps and is a highly orchestrated process on which successful infection collectively depends. Entry processes are commonly analyzed by monitoring internalized virus particles via Western blotting, polymerase chain reaction, and imaging techniques that allow scientist to track the intracellular location of the pathogen. Such studies have provided abundant direct evidence on how viruses interact with receptor molecules on the cell surface, induce cell signaling at the point of initial contact with the cell to facilitate internalization, and exploit existing endocytic mechanisms of the cell for their ultimate infectious agenda. However, there is dearth of knowledge in regards to trafficking of a virus via endosomes. Herein, we describe an optimized laboratory procedure to isolate individual organelles during different stages of endocytosis by performing subcellular fractionation. This methodology is established using Kaposi’s sarcoma-associated herpesvirus (KSHV) infection of human foreskin fibroblast (HFF) cells as a model. With KSHV and other herpesviruses alike, envelope glycoproteins have been widely reported to physically engage target cell surface receptors, such as integrins, in interactions leading to entry and subsequent infection.
Results
Subcellular fractionation was used to isolate early and late endosomes (EEs and LEs) by performing a series of centrifugations steps. Specifically, a centrifugation step post-homogenization was utilized to obtain the post-nuclear supernatant containing intact intracellular organelles in suspension. Successive fractionation via sucrose density gradient centrifugation was performed to isolate specific organelles including EEs and LEs. Intracellular KSHV trafficking was directly traced in the isolated endosomal fractions. Additionally, the subcellular fractionation approach demonstrates a key role for integrins in the endosomal trafficking of KSHV. The results obtained from fractionation studies corroborated those obtained by traditional imaging studies.
Conclusions
This study is the first of its kind to employ a sucrose flotation gradient assay to map intracellular KSHV trafficking in HFF cells. We are confident that such an approach will serve as a powerful tool to directly study intracellular trafficking of a virus, signaling events occurring on endosomal membranes, and dynamics of molecular events within endosomes that are crucial for uncoating and virus escape into the cytosol
Ni/H-ZSM-5 as a stable and promising catalyst for COx free H2 production by CH4 decomposition
Catalytic decomposition of methane for COx free hydrogen production is carried out over Ni supported on H-ZSM-5 catalysts with different Si/Al ratios (i.e. 40, 150, 300 and 485) at 550 °C and atmospheric pressure. Methane decomposition activity of Ni/H-ZSM-5 is decreased with time on stream and finally deactivated completely. The fresh and reduced catalysts are characterized by BET-SA, XRD, FT-IR, UV-DRS, TPR, pulse chemisorption of H2 and N2O and some of the used catalysts are characterised by CHNS, SEM, TEM and Raman spectroscopy. Raman spectra of the used catalysts showed both ordered and disordered carbon at 1580 cm-1 and 1320 cm-1. The 20 wt% Ni/H-ZSM-5 (Si/Al = 150) exhibited a higher H2 production rate over the other Ni loadings. The superior performance of 20 wt% Ni/H-ZSM-5 (Si/Al = 150) is rationalized by the physico-chemical properties of the various Ni loaded H-ZSM-5 catalysts
Many faces of low mass neutralino dark matter in the unconstrained MSSM, LHC data and new signals
If all strongly interacting sparticles (the squarks and the gluinos) in an
unconstrained minimal supersymmetric standard model (MSSM) are heavier than the
corresponding mass lower limits in the minimal supergravity (mSUGRA) model,
obtained by the current LHC experiments, then the existing data allow a variety
of electroweak (EW) sectors with light sparticles yielding dark matter (DM)
relic density allowed by the WMAP data. Some of the sparticles may lie just
above the existing lower bounds from LEP and lead to many novel DM producing
mechanisms not common in mSUGRA. This is illustrated by revisiting the above
squark-gluino mass limits obtained by the ATLAS Collaboration, with an
unconstrained EW sector with masses not correlated with the strong sector.
Using their selection criteria and the corresponding cross section limits, we
find at the generator level using Pythia, that the changes in the mass limits,
if any, are by at most 10-12% in most scenarios. In some cases, however, the
relaxation of the gluino mass limits are larger (). If a subset of
the strongly interacting sparticles in an unconstrained MSSM are within the
reach of the LHC, then signals sensitive to the EW sector may be obtained. This
is illustrated by simulating the \etslash, , and \etslash signals in i) the light stop scenario and ii) the light
stop-gluino scenario with various light EW sectors allowed by the WMAP data.
Some of the more general models may be realized with non-universal scalar and
gaugino masses.Comment: 27 pages, 1 figure, references added, minor changes in text, to
appear in JHE
BBMS + + – basic bioinformatics meta-searcher
In this paper we present a Basic Bioinformatics Meta-searcher (BBMS), a web-based service aiming to simplify and integrate biological data searching through selected biological databases. BBMS facilitates biological data searching enabling multiple sources transparently, increasing research productivity as it avoids time consuming learning and parameterization of different search engines. As a complementary service, BBMS provides insight and links to common online bioinformatics tools. Users’ feedback when evaluating BBMS in terms of usability, usefulness and efficiency was very positive
Properties of 125 GeV Higgs boson in non-decoupling MSSM scenarios
Tantalizing hints of the Higgs boson of mass around 125 GeV have been
reported at the LHC. We explore the MSSM parameter space in which the 125 GeV
state is identified as the heavier of the CP even Higgs bosons, and study two
scenarios where the two photon production rate can be significantly larger than
the standard model (SM). In one scenario, is
enhanced by a light stau contribution, while the () rate
stays around the SM rate. In the other scenario, is
suppressed and not only the but also the
() rates should be enhanced. The rate can be
significantly larger or smaller than the SM rate in both scenarios. Other
common features of the scenarios include top quark decays into charged Higgs
boson, single and pair production of all Higgs bosons in collisions at
GeV.Comment: 20 pages, 5 figures, accepted version for publication in JHE
New perturbation theory representation of the conformal symmetry breaking effects in gauge quantum field theory models
We propose a hypothesis on the detailed structure for the representation of
the conformal symmetry breaking term in the basic Crewther relation generalized
in the perturbation theory framework in QCD renormalized in the scheme. We establish the validity of this representation in the
approximation. Using the variant of the generalized Crewther
relation formulated here allows finding relations between specific
contributions to the QCD perturbation series coefficients for the flavor
nonsinglet part of the Adler function for the electron-positron
annihilation in hadrons and to the perturbation series coefficients for the
Bjorken sum rule for the polarized deep-inelastic lepton-nucleon
scattering. We find new relations between the coefficients of
and . Satisfaction of one of them serves as an
additional theoretical verification of the recent computer analytic
calculations of the terms of order in the expressions for these
two quantities.Comment: 12 pages, Title modified, abstract modified, improved and extended
variant of the talks, presented at Int. Seminar "Quarks-2010" (6-12 June,
2010, Kolomna) and Int. Workshop Hadron Structure and QCD: From Low to High
Energies (5-9 July 2010, Gatchina
Constraints on supersymmetry with light third family from LHC data
We present a re-interpretation of the recent ATLAS limits on supersymmetry in
channels with jets (with and without b-tags) and missing energy, in the context
of light third family squarks, while the first two squark families are
inaccessible at the 7 TeV run of the Large Hadron Collider (LHC). In contrast
to interpretations in terms of the high-scale based constrained minimal
supersymmetric standard model (CMSSM), we primarily use the low-scale
parametrisation of the phenomenological MSSM (pMSSM), and translate the limits
in terms of physical masses of the third family squarks. Side by side, we also
investigate the limits in terms of high-scale scalar non-universality, both
with and without low-mass sleptons. Our conclusion is that the limits based on
0-lepton channels are not altered by the mass-scale of sleptons, and can be
considered more or less model-independent.Comment: 20 pages, 8 figures, 2 tables. Version published in JHE
Naturalness and Fine Tuning in the NMSSM: Implications of Early LHC Results
We study the fine tuning in the parameter space of the semi-constrained
NMSSM, where most soft Susy breaking parameters are universal at the GUT scale.
We discuss the dependence of the fine tuning on the soft Susy breaking
parameters M_1/2 and m0, and on the Higgs masses in NMSSM specific scenarios
involving large singlet-doublet Higgs mixing or dominant Higgs-to-Higgs decays.
Whereas these latter scenarios allow a priori for considerably less fine tuning
than the constrained MSSM, the early LHC results rule out a large part of the
parameter space of the semi-constrained NMSSM corresponding to low values of
the fine tuning.Comment: 19 pages, 10 figures, bounds from Susy searches with ~1/fb include
Where is SUSY?
The direct searches for Superymmetry at colliders can be complemented by
direct searches for dark matter (DM) in underground experiments, if one assumes
the Lightest Supersymmetric Particle (LSP) provides the dark matter of the
universe. It will be shown that within the Constrained minimal Supersymmetric
Model (CMSSM) the direct searches for DM are complementary to direct LHC
searches for SUSY and Higgs particles using analytical formulae. A combined
excluded region from LHC, WMAP and XENON100 will be provided, showing that
within the CMSSM gluinos below 1 TeV and LSP masses below 160 GeV are excluded
(m_{1/2} > 400 GeV) independent of the squark masses.Comment: 16 pages, 10 figure
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