Can gold hedge against inflation in the UAE? A nonlinear ARDL analysis in the presence of structural breaks

Purpose – The purpose of this study is to explore the role of gold as a hedge against inflation in the case of the United Arab Emirates. Design/methodology/approach – The study utilizes monthly data on the local sharia-compliant spot gold contract traded on the Dubai Gold and Commodity Exchange (DGCX) and the corresponding consumer price index series over the period December 2015 to January 2021. The econometric approach employed by the study involves a unit root testing procedure that allows the timing of significant breaks to be estimated. A cointegration analysis is then conducted using a nonlinear autoregressive distributed lag (NARDL) model, taking into consideration the presence of structural breaks in addition to short- and long-run asymmetries. Findings – The results reveal that consumer and gold prices are cointegrated, which implies that investing in gold can hedge against inflation in the long run. No sufficient evidence, nonetheless, is found in support of the ability of gold to serve as a hedge against inflation in the short run. Originality/value – The findings have several important policy implications for policymakers and investors that are further discussed in the study

The future of Sufism in Saudi Arabia under Salafi–Sufi polemics and vision 2030’s adoption of Wasaṭiyya

In the aftermath of the poor reputation acquired by the government-supported Salafi establishment as the principal source of political Islam’s fundamentalist ideology behind Islamic terrorism, the Saudi government was compelled to rethink its internal socioreligious policies and imposition of the austere Salafism on the heterogenous Saudi society. Societal pluralism was promoted when different groups within society, Sufis, Shīʿa and liberal modernists, were all invited to participate in national dialogue forums. These forums were precursors to major socioreligious reform, as expressed in the country’s Vision 2030. Pluralism is sought in the controversial Qurʾanic concept of wasaṭiyya (middle way), hoping to provide a solid Islamic foundation for the unprecedented socioreligious change of attitude. Wasaṭiyya would achieve two premises, as advanced in this thesis. First, it would instil an intraIslamic and societal pluralism within the heterogeneous composition of Saudi society. Second, it would promote public acceptance of harmonious coexistence across cultural and religious worlds. The prevailing Salafi establishment’s definition of wasaṭiyya is not conducive to fulfilling the two premises mentioned above. Instead, this thesis proposes that an alternative Sufi-defined wasaṭiyya, grounded in taṣawwuf’s two principles of sulūk (behaviour; conduct) and akhlāq (ethics), would better fulfil the two premises. Yet, in a country known for its deeprooted Salafi abhorrence of taṣawwuf (Sufism), Sufism’s approach to wasaṭiyya cannot be addressed outside the context of the Salafi‒Sufi polemical relationship. Through a review of the literature and multimedia sources, a comparative analysis was conducted, and Salafi‒Sufi refutations and counter-refutations were identified. The research revealed that the Sufi interpretation of wasaṭiyya was inclusive, promoting pluralistic intraIslamic and a disposition towards modernist schools of thought. Taṣawwuf’s wasaṭiyya underlines a new comprehensive approach to an Islamic philosophy for life that naturally fulfils the two premises of the socioreligious-cum-political aspect of Vision 2030. Although the state of taṣawwuf in Saudi Arabia is far from widely accepted, government-supported intellectual efforts and official public media programmes about taṣawwuf target the country’s intelligentsia. This highlights the intellectual acknowledgement of true Sufism, in contrast to pseudo-Sufism, as essential to Islamic ethics. Consequently, this thesis advocates including Sufism’s two principles, sulūk and aklāq, in the country’s religious education system

Underlying Primary Causes of Chronic Renal Failure: A Three-Year Study in Al-Thawra General Hospital, Sana'a, Yemen

Objective: To estimate the underlying primary diseases of chronic renal failure (CRF) among patients attending Al-Thawra General Hospital, Sana'a, and Yemen.Methods: This was a cross-sectional, hospital-based study of 566 patients diagnosed with chronic kidney diseases (CKD). It studied the cases attending Al-Thawra General Hospital over a three‐year period from January 2013 to December 2015.Results: Out of 566 patients, 339 (59.9%) were males. The mean age of the patients at diagnosis of CKD was 39.51 years, most of whom (36.6%) were of the age group of 21–35 years. Hypertension was the most frequent cause (43.2%) of CRF, followed by different infectious diseases such as malaria, schistosomiasis and bacterial infections (19%) and obstructive nephropathy (17.9%). On the other hand, CRF of unknown etiology represented 15.2% of cases. Other causes of CRF diabetic nephropathy (9.7%), effect of antibiotics and analgesics (7.0%), ischemic heart disease (4.8%, polycystic kidney disease (3.5%) and congenital anomalies (3.4%). The least common causes were autoimmune diseases, bleeding, traumatic accidents and chronic diarrhea, being responsible for 2.2%, 1.8%, 0.9% and 0.4% of CRF cases, respectively.Conclusions: The majority of CKD cases in our study were males aged between 21 and 35 years old. In addition, most cases of CKD are due to hypertension, followed by infections and obstructive nephropathy. Application of future prevention and control measures are highly recommended to reduce the burden of CRF in Yemen for early detection and proper management of its underlying primary conditions/diseases

Prescribed medicine use and extent of off-label use according to age in a nationwide sample of Australian children

Background: Medicine prescribing for children is impacted by a lack of paediatric-specific dosing, efficacy and safety data for many medicines. Objectives: To estimate the prevalence of medicine use among children and the rate of ‘off-label’ prescribing according to age at dispensing. Methods: We used population-wide primarily outpatient dispensing claims data for 15% of Australian children (0–17 years), 2013–2017 (n = 840,190). We estimated prescribed medicine use and ‘off-label’ medicine use according to the child's age (<1 year, 1–5 years, 6–11 years, 12–17 years) defined as medicines without age-appropriate dose recommendations in regulator-approved product information. Within off-label medicines, we also identified medicines with and without age-specific dose recommendations in a national prescribing guide, the Australian Medicines Handbook Children's Dosing Companion (AMH CDC). Results: The overall dispensing rate was 2.0 dispensings per child per year. The medicines with the highest average yearly prevalence were systemic antibiotics (435.3 per 1000 children), greatest in children 1–5 years (546.9 per 1000). Other common medicine classes were systemic corticosteroids (92.7 per 1000), respiratory medicines (91.2 per 1000), acid-suppressing medicines in children <1 year (47.2 per 1000), antidepressants in children 12–17 years (40.3 per 1000) and psychostimulants in children 6–11 years (27.0 per 1000). We identified 12.2% of dispensings as off-label based on age, but 66.3% of these had age-specific dosing recommendations in the AMH CDC. Among children <1 year, off-label dispensings were commonly acid-suppressing medicines (35.5%) and topical hydrocortisone (33.1%); in children 6–11 years, off-label prescribing of clonidine (16.0%) and risperidone (13.1%) was common. Off-label dispensings were more likely to be prescribed by a specialist (21.7%) than on-label dispensings (7.5%). Conclusions: Prescribed medicine use is common in children, with off-label dispensings for medicines without paediatric-specific dosing guidelines concentrated in classes such as acid-suppressing medicines and psychotropics. Our findings highlight a need for better evidence to support best-practice prescribing

Erratum to: 36th International Symposium on Intensive Care and Emergency Medicine

[This corrects the article DOI: 10.1186/s13054-016-1208-6.]

Challenges Facing Distance Education for Children in Virtual Kindergartens

For kindergarten children, distance education was neither an alternative nor a potential option to in-person schooling before the global COVID-19 pandemic-imposed isolation and mandatory social distancing measures. These measures guaranteed the safety of school staff and children and made the adoption of distance education an urgent necessity for children to continue their education safely. The current study was conducted to reveal the most common challenges that faced children’s distance education in virtual kindergartens. The study was conducted from the teachers’ point of view to determine the impact of each of the job title variables and years of experience. The study sample consisted of 32 kindergarten teachers in Jubail Governorate. The research team applied the scale of challenges facing children’s education in virtual kindergarten. The results of the study concluded that the most important challenges facing children’s education in virtual kindergartens were related to communication skills (79.9%), technical skills (79.5%), educational aids (76.4%), and motivation (69.6%). The results of the study also revealed that there were statistically significant differences in the challenges related to motivation and readiness and in the total challenges facing children’s education in the virtual kindergarten from the teachers’ point of view depending on the job title—that is, the assistant teacher where the calculated “U” value reached 28.5 and 37.5. In addition, there was an absence of statistically significant differences due to the variable years of experience, whether in the total number of challenges or in the dimensions of the scale, except for the dimension of communication skills, where the calculated “Ka2” value reached 8.755, which is a statistically significant value at the level of significance (0.05)

Loss-of-function mutations in SLC30A8 protect against type 2 diabetes.

Neðst á síðunni er hægt að nálgast greinina í heild sinni með því að smella á hlekkinn View/OpenLoss-of-function mutations protective against human disease provide in vivo validation of therapeutic targets, but none have yet been described for type 2 diabetes (T2D). Through sequencing or genotyping of ~150,000 individuals across 5 ancestry groups, we identified 12 rare protein-truncating variants in SLC30A8, which encodes an islet zinc transporter (ZnT8) and harbors a common variant (p.Trp325Arg) associated with T2D risk and glucose and proinsulin levels. Collectively, carriers of protein-truncating variants had 65% reduced T2D risk (P = 1.7 × 10(-6)), and non-diabetic Icelandic carriers of a frameshift variant (p.Lys34Serfs*50) demonstrated reduced glucose levels (-0.17 s.d., P = 4.6 × 10(-4)). The two most common protein-truncating variants (p.Arg138* and p.Lys34Serfs*50) individually associate with T2D protection and encode unstable ZnT8 proteins. Previous functional study of SLC30A8 suggested that reduced zinc transport increases T2D risk, and phenotypic heterogeneity was observed in mouse Slc30a8 knockouts. In contrast, loss-of-function mutations in humans provide strong evidence that SLC30A8 haploinsufficiency protects against T2D, suggesting ZnT8 inhibition as a therapeutic strategy in T2D prevention.US National Institutes of Health (NIH) Training 5-T32-GM007748-33 Doris Duke Charitable Foundation 2006087 Fulbright Diabetes UK Fellowship BDA 11/0004348 Broad Institute from Pfizer, Inc. NIH U01 DK085501 U01 DK085524 U01 DK085545 U01 DK085584 Swedish Research Council Dnr 521-2010-3490 Dnr 349-2006-237 European Research Council (ERC) GENETARGET T2D GA269045 ENGAGE 2007-201413 CEED3 2008-223211 Sigrid Juselius Foundation Folkh lsan Research Foundation ERC AdG 293574 Research Council of Norway 197064/V50 KG Jebsen Foundation University of Bergen Western Norway Health Authority Lundbeck Foundation Novo Nordisk Foundation Wellcome Trust WT098017 WT064890 WT090532 WT090367 WT098381 Uppsala University Swedish Research Council and the Swedish Heart- Lung Foundation Academy of Finland 124243 102318 123885 139635 Finnish Heart Foundation Finnish Diabetes Foundation, Tekes 1510/31/06 Commission of the European Community HEALTH-F2-2007-201681 Ministry of Education and Culture of Finland European Commission Framework Programme 6 Integrated Project LSHM-CT-2004-005272 City of Kuopio and Social Insurance Institution of Finland Finnish Foundation for Cardiovascular Disease NIH/NIDDK U01-DK085545 National Heart, Lung, and Blood Institute (NHLBI) National Institute on Minority Health and Health Disparities N01 HC-95170 N01 HC-95171 N01 HC-95172 European Union Seventh Framework Programme, DIAPREPP Swedish Child Diabetes Foundation (Barndiabetesfonden) 5U01DK085526 DK088389 U54HG003067 R01DK072193 R01DK062370 Z01HG000024info:eu-repo/grantAgreement/EC/FP7/20201

Design Studio Environment: Using Biophilic Patterns for Creative Performance

In design education, the architectural design studio environment is one of the most significant environments that should be a stimulator of creativity. It's known for the amount of time students spend there, so it's considered their second home. Researchers aspire to create a unique and different design studio environment that motivates students’ creativity. This study presents the biophilia theory as a technique that generates a creative design studio environment. The purpose is to determine the applicability of the biophilic design theory patterns to the design studio environment, which in turn has an impact on motivating the students' creativity. The research method will be conducted through a comprehensive analysis of several world- famous architectural schools, by understanding the application of the principles of nature and connecting them with biophilic patterns. As a result, the research has yielded applicable criteria for biophilic patterns in existing design studios

Population‐based cohort study of outcomes following cholecystectomy for benign gallbladder diseases

Background The aim was to describe the management of benign gallbladder disease and identify characteristics associated with all‐cause 30‐day readmissions and complications in a prospective population‐based cohort. Methods Data were collected on consecutive patients undergoing cholecystectomy in acute UK and Irish hospitals between 1 March and 1 May 2014. Potential explanatory variables influencing all‐cause 30‐day readmissions and complications were analysed by means of multilevel, multivariable logistic regression modelling using a two‐level hierarchical structure with patients (level 1) nested within hospitals (level 2). Results Data were collected on 8909 patients undergoing cholecystectomy from 167 hospitals. Some 1451 cholecystectomies (16·3 per cent) were performed as an emergency, 4165 (46·8 per cent) as elective operations, and 3293 patients (37·0 per cent) had had at least one previous emergency admission, but had surgery on a delayed basis. The readmission and complication rates at 30 days were 7·1 per cent (633 of 8909) and 10·8 per cent (962 of 8909) respectively. Both readmissions and complications were independently associated with increasing ASA fitness grade, duration of surgery, and increasing numbers of emergency admissions with gallbladder disease before cholecystectomy. No identifiable hospital characteristics were linked to readmissions and complications. Conclusion Readmissions and complications following cholecystectomy are common and associated with patient and disease characteristics

Exploring environmental sustainability in dentistry among students and educators in the United Arab Emirates: a cross-sectional survey.

OBJECTIVES: Creating environmentally sustainable healthcare culture within the dental field requires embedding the content in the dental curriculum at the undergraduate level. This study aimed to explore the current awareness and drivers among dental students and educators regarding environmentally sustainable dentistry (ESD) in the United Arab Emirates (UAE) and identify barriers and enablers to embrace it. METHODS: A cross-sectional survey using online questionnaires was carried out in six undergraduate dental education institutes within the UAE. Data analysis included descriptive statistics. RESULTS: In total 153 students and 53 educators participated in the survey. Most students and educators were not aware of any ESD content in their curricula. However, the majority of educators were familiar with the concept of ESD, while students were mostly unfamiliar or slightly familiar. Nonetheless, students largely agreed on its importance and their interest in learning it, as they viewed it relevant to their future practice. Educators agreed that the dental profession has a responsibility to be environmentally friendly and expressed their desire in introducing ESD content into the curricula. Several barriers were reported such as lack of knowledge, curricula space, educational resources, and time. Meanwhile, enablers included providing ESD capacity building, training and resources. CONCLUSIONS: There was no explicit presence of ESD content in the dental curricula in the UAE. Despite the lack of adequate awareness on this topic among educators and more so among students, they both had positive views towards incorporating ESD into dental curricula. Overall, this study highlighted the importance of promoting ESD in dental programs. CLINICAL SIGNIFICANCE: ESD is gradually becoming a critical aspect of modern oral healthcare system. It has been mandated in the dental curricula in several regions globally. Embedding ESD in the UAE dental curricula would have several benefits for the environment as well as the future of the dental profession in the region. The clinical significance includes, but not limited to, improved treatment outcomes; patients, students and staff health and well-being; reduced health risks, and cost savings