4,925 research outputs found

    Graviton production through photon-quark scattering at the LHC

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    We have investigated real graviton emission in the ADD and RS model of extra dimensions through the photoproduction process pp-> p gamma p-> pGqX at the LHC. We have considered all contributions from the subprocesses gamma q -> G q, where q=u,d,c,s,b,anti-u,anti-d, anti-c, anti-s, anti-b quark. The constraints on model parameters of the ADD and RS model of extra dimensions have been calculated. During numerical calculations we have taken account of 3, 4, 5 and 6 large extra dimensional scenarios. The constraints on RS model parameters have been calculated by considering G -> gamma gamma, e^- e^+, mu^- mu^+ decay channels of the graviton.Comment: 27 pages, 12 figures; final version to appear in PR

    Constraining the magnitude of the Chiral Magnetic Effect with Event Shape Engineering in Pb-Pb collisions at sNN\sqrt{s_{\rm NN}} = 2.76$ TeV

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    In ultrarelativistic heavy-ion collisions, the event-by-event variation of the elliptic flow v2v_2 reflects fluctuations in the shape of the initial state of the system. This allows to select events with the same centrality but different initial geometry. This selection technique, Event Shape Engineering, has been used in the analysis of charge-dependent two- and three-particle correlations in Pb-Pb collisions at sNN=2.76\sqrt{s_{_{\rm NN}}} =2.76 TeV. The two-particle correlator cos(φαφβ)\langle \cos(\varphi_\alpha - \varphi_\beta) \rangle, calculated for different combinations of charges α\alpha and β\beta, is almost independent of v2v_2 (for a given centrality), while the three-particle correlator cos(φα+φβ2Ψ2)\langle \cos(\varphi_\alpha + \varphi_\beta - 2\Psi_2) \rangle scales almost linearly both with the event v2v_2 and charged-particle pseudorapidity density. The charge dependence of the three-particle correlator is often interpreted as evidence for the Chiral Magnetic Effect (CME), a parity violating effect of the strong interaction. However, its measured dependence on v2v_2 points to a large non-CME contribution to the correlator. Comparing the results with Monte Carlo calculations including a magnetic field due to the spectators, the upper limit of the CME signal contribution to the three-particle correlator in the 10-50% centrality interval is found to be 26-33% at 95% confidence level.Comment: 20 pages, 6 captioned figures, 1 tables, authors from page 15, published version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/382

    Measurement of the production of charm jets tagged with D0^{0} mesons in pp collisions at s\sqrt{s}= 7 TeV

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    The production of charm jets in proton-proton collisions at a center-of-mass energy of s=7\sqrt{s}=7 TeV was measured with the ALICE detector at the CERN Large Hadron Collider. The measurement is based on a data sample corresponding to a total integrated luminosity of 6.236.23 nb1{\rm nb}^{-1}, collected using a minimum-bias trigger. Charm jets are identified by the presence of a D0^0 meson among their constituents. The D0^0 mesons are reconstructed from their hadronic decay D0^0\rightarrowKπ+^{-}\pi^{+}. The D0^0-meson tagged jets are reconstructed using tracks of charged particles (track-based jets) with the anti-kTk_{\mathrm{T}} algorithm in the jet transverse momentum range 5<pT,jetch<305<p_{\rm{T,jet}}^{\mathrm{ch}}<30 GeV/c{\rm GeV/}c and pseudorapidity ηjet<0.5|\eta_{\rm jet}|<0.5. The fraction of charged jets containing a D0^0-meson increases with pT,jetchp_{\rm{T,jet}}^{\rm{ch}} from 0.042±0.004(stat)±0.006(syst)0.042 \pm 0.004\, \mathrm{(stat)} \pm 0.006\, \mathrm{(syst)} to 0.080±0.009(stat)±0.008(syst)0.080 \pm 0.009\, \rm{(stat)} \pm 0.008\, \rm{(syst)}. The distribution of D0^0-meson tagged jets as a function of the jet momentum fraction carried by the D0^0 meson in the direction of the jet axis (zchz_{||}^{\mathrm{ch}}) is reported for two ranges of jet transverse momenta, 5<pT,jetch<155<p_{\rm{T,jet}}^{\rm{ch}}<15 GeV/c{\rm GeV/}c and 15<pT,jetch<3015<p_{\rm{T,jet}}^{\rm{ch}}<30 GeV/c{\rm GeV/}c in the intervals 0.2<zch<1.00.2<z_{||}^{\rm{ch}}<1.0 and 0.4<zch<1.00.4<z_{||}^{\rm{ch}}<1.0, respectively. The data are compared with results from Monte Carlo event generators (PYTHIA 6, PYTHIA 8 and Herwig 7) and with a Next-to-Leading-Order perturbative Quantum Chromodynamics calculation, obtained with the POWHEG method and interfaced with PYTHIA 6 for the generation of the parton shower, fragmentation, hadronisation and underlying event.Comment: 29 pages, 8 captioned figures, 3 tables, authors from page 24, published version, figures at http://alice-publications.web.cern.ch/node/525

    CD20 and CD19 targeted vectors induce minimal activation of resting B lymphocytes

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    B lymphocytes are an important cell population of the immune system. However, until recently it was not possible to transduce resting B lymphocytes with retro- or lentiviral vectors, making them unsusceptible for genetic manipulations by these vectors. Lately, we demonstrated that lentiviral vectors pseudotyped with modified measles virus (MV) glycoproteins hemagglutinin, responsible for receptor recognition, and fusion protein were able to overcome this transduction block. They use either the natural MV receptors, CD46 and signaling lymphocyte activation molecule (SLAM), for cell entry (MV-LV) or the vector particles were further modified to selectively enter via the CD20 molecule, which is exclusively expressed on B lymphocytes (CD20-LV). It has been shown previously that transduction by MV-LV does not induce B lymphocyte activation. However, if this is also true for CD20-LV is still unknown. Here, we generated a vector specific for another B lymphocyte marker, CD19, and compared its ability to transduce resting B lymphocytes with CD20-LV. The vector (CD19ds-LV) was able to stably transduce unstimulated B lymphocytes, albeit with a reduced efficiency of about 10% compared to CD20-LV, which transduced about 30% of the cells. Since CD20 as well as CD19 are closely linked to the B lymphocyte activation pathway, we investigated if engagement of CD20 or CD19 molecules by the vector particles induces activating stimuli in resting B lymphocytes. Although, activation of B lymphocytes often involves calcium influx, we did not detect elevated calcium levels. However, the activation marker CD71 was substantially up-regulated upon CD20-LV transduction and most importantly, B lymphocytes transduced with CD20-LV or CD19ds-LV entered the G1b phase of cell cycle, whereas untransduced or MV-LV transduced B lymphocytes remained in G0. Hence, CD20 and CD19 targeting vectors induce activating stimuli in resting B lymphocytes, which most likely renders them susceptible for lentiviral vector transduction

    INFN What Next: Ultra-relativistic Heavy-Ion Collisions

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    This document was prepared by the community that is active in Italy, within INFN (Istituto Nazionale di Fisica Nucleare), in the field of ultra-relativistic heavy-ion collisions. The experimental study of the phase diagram of strongly-interacting matter and of the Quark-Gluon Plasma (QGP) deconfined state will proceed, in the next 10-15 years, along two directions: the high-energy regime at RHIC and at the LHC, and the low-energy regime at FAIR, NICA, SPS and RHIC. The Italian community is strongly involved in the present and future programme of the ALICE experiment, the upgrade of which will open, in the 2020s, a new phase of high-precision characterisation of the QGP properties at the LHC. As a complement of this main activity, there is a growing interest in a possible future experiment at the SPS, which would target the search for the onset of deconfinement using dimuon measurements. On a longer timescale, the community looks with interest at the ongoing studies and discussions on a possible fixed-target programme using the LHC ion beams and on the Future Circular Collider.Comment: 99 pages, 56 figure

    Multiplicity dependence of jet-like two-particle correlations in p-Pb collisions at sNN\sqrt{s_{NN}} = 5.02 TeV

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    Two-particle angular correlations between unidentified charged trigger and associated particles are measured by the ALICE detector in p-Pb collisions at a nucleon-nucleon centre-of-mass energy of 5.02 TeV. The transverse-momentum range 0.7 <pT,assoc<pT,trig< < p_{\rm{T}, assoc} < p_{\rm{T}, trig} < 5.0 GeV/cc is examined, to include correlations induced by jets originating from low momen\-tum-transfer scatterings (minijets). The correlations expressed as associated yield per trigger particle are obtained in the pseudorapidity range η<0.9|\eta|<0.9. The near-side long-range pseudorapidity correlations observed in high-multiplicity p-Pb collisions are subtracted from both near-side short-range and away-side correlations in order to remove the non-jet-like components. The yields in the jet-like peaks are found to be invariant with event multiplicity with the exception of events with low multiplicity. This invariance is consistent with the particles being produced via the incoherent fragmentation of multiple parton--parton scatterings, while the yield related to the previously observed ridge structures is not jet-related. The number of uncorrelated sources of particle production is found to increase linearly with multiplicity, suggesting no saturation of the number of multi-parton interactions even in the highest multiplicity p-Pb collisions. Further, the number scales in the intermediate multiplicity region with the number of binary nucleon-nucleon collisions estimated with a Glauber Monte-Carlo simulation.Comment: 23 pages, 6 captioned figures, 1 table, authors from page 17, published version, figures at http://aliceinfo.cern.ch/ArtSubmission/node/161
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