Models of Assignment on Endocrine and Reproduction Block (1.5), Faculty of Medicine, Islamic University of Indonesia (FM IUI)

Background: Doctor\u27s competency in Indonesia covers seven pillars namely noble professionalism and ethics, self-development and selfcontrol, effective communication, information management, scientificfoundation of medicine, clinical skills, and problem management on public health. One of the efforts to achieve the competency especially on ethics, self development and information management competency, FM IUI has used assignment model in Block of 1.5.Objective: The study was conducted to describe the models of assignment to increase the ability of writing skill citation and bibliography using Mendeley, to avoid plagiarism using VIPER and to access journal using Clinical Key.Methods: This descriptive study focused on all students following Block 1.5 which consists of 45 male students and 95 female students. The research instrument was questionnaire for collecting data from all respondents after assignment finished.Results: Three models of assignment is used to increase the ability in writing using Mendeley, to avoid plagiarism using VIPER and to increase in accessing electronic journal (ClinicalKey). First week on Block of 1.5 was to introduce the assignment and practical work using CinicalKey, Mendeley and VIPER. The comparison between before and after assignment to use Mendeley, VIPER and ClinicalKey analyzed from questionnaire.Conclusion: The percentage of students in using Mendeley, ClinicalKey and VIPER has increased up to 90 %

BPS and non-BPS states in a supersymmetric Landau-Ginzburg theory

We analyze the spectrum of the N=(2,2) supersymmetric Landau-Ginzburg theory in two dimensions with superpotential W=X^{n+2}-lambda X^2. We find the full BPS spectrum of this theory by exploiting the direct connection between the UV and IR limits of the theory. The computation utilizes results from the Picard-Lefschetz theory of singularities and its extension to boundary singularities. The additional fact that this theory is integrable requires that the BPS states do not close under scattering. This observation fixes the masses of non-BPS states as well.Comment: 27 pages, 12 figure

Neurobehavioral function and low-level exposure to brominated flame retardants in adolescents : a cross-sectional study

Background: Animal and in vitro studies demonstrated a neurotoxic potential of brominated flame retardants, a group of chemicals used in many household and commercial products to prevent fire. Although the first reports of detrimental neurobehavioral effects in rodents appeared more than ten years ago, human data are sparse. Methods: As a part of a biomonitoring program for environmental health surveillance in Flanders, Belgium, we assessed the neurobehavioral function with the Neurobehavioral Evaluation System (NES-3), and collected blood samples in a group of high school students. Cross-sectional data on 515 adolescents (13.6-17 years of age) was available for the analysis. Multiple regression models accounting for potential confounders were used to investigate the associations between biomarkers of internal exposure to brominated flame retardants [serum levels of polybrominated diphenyl ether (PBDE) congeners 47, 99, 100, 153, 209, hexabromocyclododecane (HBCD), and tetrabromobisphenol A (TBBPA)] and cognitive performance. In addition, we investigated the association between brominated flame retardants and serum levels of FT3, FT4, and TSH. Results: A two-fold increase of the sum of serum PBDE's was associated with a decrease of the number of taps with the preferred-hand in the Finger Tapping test by 5.31 (95% CI: 0.56 to 10.05, p = 0.029). The effects of the individual PBDE congeners on the motor speed were consistent. Serum levels above the level of quantification were associated with an average decrease of FT3 level by 0.18 pg/mL (95% CI: 0.03 to 0.34, p = 0.020) for PBDE-99 and by 0.15 pg/mL (95% CI: 0.004 to 0.29, p = 0.045) for PBDE-100, compared with concentrations below the level of quantification. PBDE-47 level above the level of quantification was associated with an average increase of TSH levels by 10.1% (95% CI: 0.8% to 20.2%, p = 0.033), compared with concentrations below the level of quantification. We did not observe effects of PBDE's on neurobehavioral domains other than the motor function. HBCD and TBBPA did not show consistent associations with performance in the neurobehavioral tests. Conclusions: This study is one of few studies and so far the largest one investigating the neurobehavioral effects of brominated flame retardants in humans. Consistently with experimental animal data, PBDE exposure was associated with changes in the motor function and the serum levels of the thyroid hormones

Two-loop world-sheet corrections in AdS_5 x S^5 superstring

We initiate the computation of the 2-loop quantum AdS_5 x S^5 string corrections on the example of a certain string configuration in S^5 related by an analytic continuation to a folded rotating string in AdS_5 in the ``long string'' limit. The 2-loop term in the energy of the latter should represent the subleading strong-coupling correction to the cusp anomalous dimension and thus provide a further check of recent conjectures about the exact structure of the Bethe ansatz underlying the AdS/CFT duality. We use the conformal gauge and several choices of the \kappa-symmetry gauge. While we are unable to verify the cancellation of 2d UV divergences we compute the bosonic contribution to the effective action and also determine the non-trivial finite part of the fermionic contribution. Both the bosonic and the fermionic contributions to the string energy happen to be proportional to the Catalan's constant. The resulting value for 2-loop superstring prediction for the subleading coefficient a_2 in the scaling function matches the numerical value found in hep-th/0611135 from the BES equation.Comment: 48 pages, 1 Figure. v3: several mistakes corrected, the finite result for the 2-loop coefficient is found to agree with the numerical value found by Benna et al in hep-th/061113

Lassoing and corraling rooted phylogenetic trees

The construction of a dendogram on a set of individuals is a key component of a genomewide association study. However even with modern sequencing technologies the distances on the individuals required for the construction of such a structure may not always be reliable making it tempting to exclude them from an analysis. This, in turn, results in an input set for dendogram construction that consists of only partial distance information which raises the following fundamental question. For what subset of its leaf set can we reconstruct uniquely the dendogram from the distances that it induces on that subset. By formalizing a dendogram in terms of an edge-weighted, rooted phylogenetic tree on a pre-given finite set X with |X|>2 whose edge-weighting is equidistant and a set of partial distances on X in terms of a set L of 2-subsets of X, we investigate this problem in terms of when such a tree is lassoed, that is, uniquely determined by the elements in L. For this we consider four different formalizations of the idea of "uniquely determining" giving rise to four distinct types of lassos. We present characterizations for all of them in terms of the child-edge graphs of the interior vertices of such a tree. Our characterizations imply in particular that in case the tree in question is binary then all four types of lasso must coincide

Strings on type IIB pp-wave backgrounds with interacting massive theories on the worldsheet

We consider superstring theories on pp-wave backgrounds which result in an integrable ${\cal N}=(2,2)$ supersymmetric Landau-Ginzburg theory on the worldsheet. We obtain exact eigenvalues of the light-cone gauge superstring hamiltonian in the massive and interacting world-sheet theory with superpotential $Z^3-Z$. We find the modes of the supergravity part of the string spectrum, and their space-time interpretation. Because the system is effectively at strong coupling on the worldsheet, these modes are not in one-to-one correspondence with the usual type IIB supergravity modes in the $p_{-} \to 0$ limit. However, the above correspondence holds in the $\alpha'\to 0$ limit.Comment: 20 pages, 1 figure; minor changes, comments adde

Infinite spin limit of semiclassical string states

Motivated by recent works of Hofman and Maldacena and Dorey we consider a special infinite spin limit of semiclassical spinning string states in AdS5 x S5. We discuss examples of known folded and circular 2-spin string solutions and demonstrate explicitly that the 1-loop superstring correction to the classical expression for the energy vanishes in the limit when one of the spins is much larger that the other. We also give a general discussion of this limit at the level of integral equations describing finite gap solutions of the string sigma model and argue that the corresponding asymptotic form of the string and gauge Bethe equations is the same.Comment: 38 pages, 3 figures; v2: comments on derivation of bound states of magnons from discrete Bethe equations added in section 4 and appendix C, references added, Imperial-TP-AT-6-4, HUTP-06/A002

An evolutionarily-unique heterodimeric voltage-gated cation channel found in aphids

We describe the identification in aphids of a unique heterodimeric voltage-gated sodium channel which has an atypical ion selectivity filter and, unusually for insect channels, is highly insensitive to tetrodotoxin. We demonstrate that this channel has most likely arisen by adaptation (gene fission or duplication) of an invertebrate ancestral mono(hetero)meric channel. This is the only identifiable voltage-gated sodium channel homologue in the aphid genome(s), and the channel's novel selectivity filter motif (DENS instead of the usual DEKA found in other eukaryotes) may result in a loss of sodium selectivity, as indicated experimentally in mutagenised Drosophila channels

DISTMIX: direct imputation of summary statistics for unmeasured SNPs from mixed ethnicity cohorts

Motivation: To increase the signal resolution for large-scale meta-analyses of genome-wide association studies, genotypes at unmeasured single nucleotide polymorphisms (SNPs) are commonly imputed using large multi-ethnic reference panels. However, the ever increasing size and ethnic diversity of both reference panels and cohorts makes genotype imputation computationally challenging for moderately sized computer clusters. Moreover, genotype imputation requires subject-level genetic data, which unlike summary statistics provided by virtually all studies, is not publicly available. While there are much less demanding methods which avoid the genotype imputation step by directly imputing SNP statistics, e.g. Directly Imputing summary STatistics (DIST) proposed by our group, their implicit assumptions make them applicable only to ethnically homogeneous cohorts. Results: To decrease computational and access requirements for the analysis of cosmopolitan cohorts, we propose DISTMIX, which extends DIST capabilities to the analysis of mixed ethnicity cohorts. The method uses a relevant reference panel to directly impute unmeasured SNP statistics based only on statistics at measured SNPs and estimated/user-specified ethnic proportions. Simulations show that the proposed method adequately controls the Type I error rates. The 1000 Genomes panel imputation of summary statistics from the ethnically diverse Psychiatric Genetic Consortium Schizophrenia Phase 2 suggests that, when compared to genotype imputation methods, DISTMIX offers comparable imputation accuracy for only a fraction of computational resources

Alemtuzumab preconditioning with tacrolimus monotherapy - The impact of serial monitoring for donor-specific antibody

BACKGROUND. Antibody preconditioning with tacrolimus monotherapy has allowed many renal allograft recipients to be maintained on spaced weaning. METHODS. Of 279 renal allograft recipients transplanted between March 2003 and December 2004, 222 (80%) had spaced weaning (i.e., reduction of tacrolimus monotherapy dosing to every other day, three times a week, twice a week, or once a week) attempted. Routine monitoring for donor-specific antibody (DSA) was begun in September 2004. Mean follow-up is 34±6.5 months after transplantation and 26±8.1 months after the initiation of spaced weaning. RESULTS. One hundred and twenty-two (44%) patients remained on spaced weaning. One- and 2-year actual patient/graft survival was 99%/99%, and 97%/96%. Fifty-six (20%) patients experienced acute rejection after initiation of spaced weaning. One- and 2-year actual patient/graft survival was 100%/98%, and 94%/78%. Forty-two (15%) patients with stable renal function had spaced weaning stopped because of the development of DSA, which disappeared in 17 (40%). One- and 2-year actual patient and graft survival was 100% and 100%. CONCLUSION. Adult renal transplant recipients who are able to be maintained on spaced weaning have excellent outcomes. Patients with stable renal function who have reversal of weaning because of the development of DSA also have excellent outcomes. Routine monitoring for DSA may allow patients to avoid late rejection after spaced weaning. © 2008 Lippincott Williams & Wilkins, Inc