SUPREME-HN: a retrospective biomarker study assessing the prognostic value of PD-L1 expression in patients with recurrent and/or metastatic squamous cell carcinoma of the head and neck.

BACKGROUND:Programmed cell death ligand-1 (PD-L1) expression on tumor cells (TCs) is associated with improved survival in patients with head and neck squamous cell carcinoma (HNSCC) treated with immunotherapy, although its role as a prognostic factor is controversial. This study investigates whether tumoral expression of PD-L1 is a prognostic marker in patients with recurrent and/or metastatic (R/M) HNSCC treated with standard chemotherapy. METHODS:This retrospective, multicenter, noninterventional study assessed PD-L1 expression on archival R/M HNSCC tissue samples using the VENTANA PD-L1 (SP263) Assay. PD-L1 high was defined as PD-L1 staining of ≥ 25% TC, with exploratory scoring at TC ≥ 10% and TC ≥ 50%. The primary objective of this study was to estimate the prognostic value of PD-L1 status in terms of overall survival (OS) in patients with R/M HNSCC. RESULTS:412 patients (median age, 62.0 years; 79.9% male; 88.2% Caucasian) were included from 19 sites in seven countries. 132 patients (32.0%) had TC ≥ 25% PD-L1 expression; 199 patients (48.3%) and 85 patients (20.6%) had TC ≥ 10% and ≥ 50%, respectively. OS did not differ significantly across PD-L1 expression (at TC ≥ 25% cutoff median OS: 8.2 months vs TC < 25%, 10.1 months, P = 0.55) or the ≥ 10% and ≥ 50% cutoffs (at TC ≥ 10%, median OS: 9.6 months vs TC < 10%, 9.4 months, P = 0.32, and at TC ≥ 50%, median OS 7.9 vs TC < 50%, 10.0 months, P = 0.39, respectively). CONCLUSIONS:PD-L1 expression, assessed using the VENTANA PD-L1 (SP263) Assay, was not prognostic of OS in patients with R/M HNSCC treated with standard of care chemotherapies. Trial registration ClinicalTrials.gov, NCT02543476. Registered September 4, 2015

Testing for Long-Run Relation between Economic Growth and Export Earnings of Cocoa in Ghana using Co-Integration Techniques

In this study, we explore the causal influence of export earnings of cocoa towards economic growth (i.e., gross domestic product (GDP)). The augmented Dickey–Fuller (ADF) and the Phillips–Perron (PP) unit root tests indicate that the two series are integrated of order one, I (1). The results of the trace and the maxi-eigenvalue cointegration test based on Johansen’s procedure indicate the existence of a cointegration between export earnings of cocoa and GDP. Thus, the two variables of the study have a long-run equilibrium relationship. The vector error correction model of order two, VECM (2), was considered as the “best” model after evaluating other competing models. It is observed that, in the long-run, previous year export earnings of cocoa is positively related to economic growth. In the short run, the results revealed that the previous GDP has positive effect on current GDP; and higher export earnings of cocoa have positive effect on GDP. Feedback causality is observed between economic growth (GDP) and export earnings of cocoa. This suggests a bi-directional causality from export earnings to economic growth (GDP). Keywords: Cointegration, VECM, Johansen, ADF, Causality

Subcontracting versus health and safety:An inverse relationship

The construction industry has an unenviable reputation of being one of the worst industries in the UK in respect of health and safety (H&S) performance. Among other factors, research points to subcontracting as one of the factors influencing safety performance on construction sites. With about 80% of construction works in the UK being subcontracted, clearly it has become imperative to investigate this inverse subcontracting-H&S relationship. This situation is exacerbated by the increasing complexity of construction technologies which inevitably implies growth in specialisation, hence an increase in subcontracting. A critique of literature on H&S and subcontracting shows that this phenomenon is attributable inter alia to the lack of resources by small subcontractors to enable them invest in H&S, ambiguities about H&S responsibilities arising from complex subcontracting relationships, and the fierce level of competition for contracts among subcontractors resulting in economic survival being prioritised over H&S. Putting these factors in context, the main arguments giving justification for the need for further research into this phenomenon are indicated. The critical research questions, research aim and objectives are also highlighted, thus setting the premise for research work to expound on these factors and offer suggestions for mitigating this inverse relationship

Factors impacting antiretroviral therapy adherence among human immunodeficiency virus-positive adolescents in Sub-Saharan Africa: a systematic review

© 2018 The Royal Society for Public Health. Published by Elsevier Ltd. All rights reserved.Objectives: Eighty-two percent of human immunodeficiency virus (HIV)–positive adolescents live in Sub-Saharan Africa (SSA). Despite the availability of antiretroviral therapy (ART), adherence levels are suboptimal, leading to poor outcomes. This systematic review investigated factors impacting ART adherence among adolescents in SSA, including religious beliefs and intimate relationships. Methods: A systematic review was conducted between June and August 2016 using eight electronic databases, including Cochrane and PubMed. Published, ongoing and unpublished research, conducted in SSA from 2004 to 2016, was identified and thematic analysis was used to summarise findings. Results: Eleven studies from eight SSA countries, published in English between 2011 and 2016, reported on factors impacting ART adherence among adolescents living with HIV (ALHIV). Forty-four barriers and 29 facilitators to adherence were identified, representing a complex web of factors. The main barriers were stigma, ART side-effects, lack of assistance and forgetfulness. Facilitators included caregiver support, peer support groups and knowledge of HIV status. Conclusions: Stigma reflects difficult relations between ALHIV and their HIV-negative peers and adults. Most interventions target only those with HIV, suggesting a policy shift towards the wider community could be beneficial. Recommendations include engaging religious leaders and schools to change negative societal attitudes. Limitations of the review include the urban settings and recruitment of predominantly vertically infected participants in most included studies. Therefore, the findings cannot be extrapolated to ALHIV residing in rural locations or horizontally infected ALHIV, highlighting the need for further research in those areas.Peer reviewedFinal Accepted Versio

Integrating Knowledge Graphs for Analysing Academia and Industry Dynamics

Academia and industry are constantly engaged in a joint effort for producing scientific knowledge that will shape the society of the future. Analysing the knowledge flow between them and understanding how they influence each other is a critical task for researchers, governments, funding bodies, investors, and companies. However, current corpora are unfit to support large-scale analysis of the knowledge flow between academia and industry since they lack of a good characterization of research topics and industrial sectors. In this short paper, we introduce the Academia/Industry DynAmics (AIDA) Knowledge Graph, which characterizes 14M papers and 8M patents according to the research topics drawn from the Computer Science Ontology. 4M papers and 5M patents are also classified according to the type of the author's affiliations (academy, industry, or collaborative) and 66 industrial sectors (e.g., automotive, financial, energy, electronics) obtained from DBpedia. AIDA was generated by an automatic pipeline that integrates several knowledge graphs and bibliographic corpora, including Microsoft Academic Graph, Dimensions, English DBpedia, the Computer Science Ontology, and the Global Research Identifier Database

Heterogeneous inter-organizational social capital: the case of Faraday Partnerships for technology transfer

Given its tripartite impact on society, industry, and university, the phenomenon of university-industry partnership (UIP) has become a valuable research endeavor. However, examining UIP-related literature shows limited understanding from a social capital (SC) perspective, albeit its relevance (as UIP comprises extensive social interaction) and capacity (being an important resource latent in networks system). Likewise, it is noticeable that research on inter-organizational SC has been predominantly conducted from the perspective of homogenous organizations (i.e., have consistent expectation, mission, and culture). However, the perspective of social interaction between heterogeneous organizations (i.e., belong to different sectors thus inherently different) is limited. We address these two gaps by investigating the idiosyncrasy of SC development in the setting of UIP, as a unique context for heterogeneous inter-organizational SC. We contribute to the literature by exposing the various facets of SC dynamics as evolve in this uncommon domain. Also, we identify four factors as moderating the interaction between the three dimensions of SC that eventually influence the dual processes of technology translation and transfer

Early and Late Strength Characterization of Portland Cement Containing Calcined Low-Grade Kaolin Clay

Heat treated low-grade kaolin clays are now considered as a suitable pozzolanic material to metakaolins. However their suitability as a good pozzolanic material depends on the geochemistry and structure of the clay which is usually influenced by the geographical environment. This study investigated a low-grade kaolin clay from Nyamebekyere in the Ashanti Region of Ghana. The influence of the calcined material on the early and late strength development of Portland cement was analyzed. The early 3- and 7-day strength as well as the late 28-day strength of Portland cement replaced with 20% by weight of the calcined material yielded the optimum strength values. Further analysis using Solid State Magic Angle Spinning Nuclear Magnetic Resonance (Ss MAS NMR) probed into the Aluminium (Al) environment to detect the presence and nature of Al hydrates using the optimum mixture proportion. The Ss MAS NMR results showed that the strength enhancement of the optimum mixture was due to the growth of stable monosulphate compounds at the octahedral environment resulting from metastable aluminate phases at the tetrahedral environment. For greater reliability on concrete strength performance, the study recommends the use of 20% calcined clay of Nyamebekyere clay as Portland cement replacement

Promoting Partnership with Traditional Authorities in Development Projects: A Model for Community Infrastructure Project Delivery in Ghana

Promoting partnership with traditional Authority Project (PPTAP) was designed to translate into reality the vision of having our traditional leaders play pivotal roles in community devel­opment. The project was to test the role that chiefs, queen mothers and other opinion leaders could play in the decentralization of community development. In spite of the presence of some challenges with respect to project implementation such as slow pace in the payment of coun­terpart fund contribution, this novelty achieved spectacular successes. This paper discusses the results of a questionnaire survey that looked at the role played by traditional authorities and community involvement in infrastructure development for 40 selected communities in Ashanti region under the PPTAP, with support from the International Development Agency (IDA) of the World Bank and the Government of Ghana. The paper concludes that the inclusion of tradi­tional authorities in beneficiary communities helped in an accurate identification of community needs, minimization of cost incurred and high-quality workmanship as well as strengthened ownership. For community based development, the paper recommends a Tripartite Partnership (TTP), where Traditional Authorities work in tandem with the Public and Private Sector to ensure sustainable national development. PPTAP presents an excellent framework for such TPP arrangements. Keywords: Traditional Authorities, Community Based Project, Infrastructure, Developmen

Resting electrocardiographic and echocardiographic findings in an urban community in the Gambia

The presence of Left Ventricular Hypertrophy (LVH) in a patient with systemic hypertension deserves serious attention and makes its clinical diagnosis a priority. Over the years various criteriahave been proposed for the electrographic (ECG) diagnosis of LVH and the sensitivity and specificity of these criteria have been extensively studied in Caucasians. Recent evidence indicates that they areinapplicable to people of African descent. Unlike echocardiography (ECHO), the ECG is generally available, cheap but has a lower sensitivity in detecting LVH compared to echocardiography. Thisstudy was conducted to evaluate ECG criteria against 2-dimensional (2-D) guided M-mode echocardiography in the diagnosis of LVH in adult Gambians. Secondly, to determine the ECG criteria usingthe Minnesota, Araoye, Sokolow and Lyon or Wolff criteria with the overall best accuracy for the diagnosis of LVH. Two hundred and eight (208) consecutive patients with systemic hypertension (BP.140/90mmHg) with or without treatment and an age matched group of 108 non-hypertensive patients were enrolled from outpatient clinics. A questionnaire was filled. All patients were investigated with 2-D guided M-mode echocardiography and a standard 12-1ead ECG. Anthropometric measurements were also taken. The gold standard was the Penn formula to determine the left ventricular mass index (of 125 g/m2 in males and 110 g/m2 in females as the cut-off for LVH). Using this gold standard the prevalence of echocardiographic LVH was 47.5% and 27.8 % in the hypertensives and non-hypertensives respectively (P 0.05). Sokolow and Lyon criterion had overall best accuracy for the electrocardiographic diagnosis of left ventricular hypertrophyin hypertensives and is further recommended for use as such. But for non-hypertensives, the Wolff criterion had overall best accuracy

ResearchFlow: Understanding the Knowledge Flow between Academia and Industry

Understanding, monitoring, and predicting the flow of knowledge between academia and industry is of critical importance for a variety of stakeholders, including governments, funding bodies, researchers, investors, and companies. To this purpose, we introduce ResearchFlow, an approach that integrates semantic technologies and machine learning to quantifying the diachronic behaviour of research topics across academia and industry. ResearchFlow exploits the novel Academia/Industry DynAmics (AIDA) Knowledge Graph in order to characterize each topic according to the frequency in time of the related i) publications from academia, ii) publications from industry, iii) patents from academia, and iv) patents from industry. This representation is then used to produce several analytics regarding the academia/industry knowledge flow and to forecast the impact of research topics on industry. We applied ResearchFlow to a dataset of 3.5M papers and 2M patents in Computer Science and highlighted several interesting patterns. We found that 89.8% of the topics first emerge in academic publications, which typically precede industrial publications by about 5.6 years and industrial patents by about 6.6 years. However this does not mean that academia always dictates the research agenda. In fact, our analysis also shows that industrial trends tend to influence academia more than academic trends affect industry. We evaluated ResearchFlow on the task of forecasting the impact of research topics on the industrial sector and found that its granular characterization of topics improves significantly the performance with respect to alternative solutions