A Cenozoic-style scenario for the end-Ordovician glaciation

The end-Ordovician was an enigmatic interval in the Phanerozoic, known for massive glaciation potentially at elevated CO2 levels, biogeochemical cycle disruptions recorded as large isotope anomalies and a devastating extinction event. Ice-sheet volumes claimed to be twice those of the Last Glacial Maximum paradoxically coincided with oceans as warm as today. Here we argue that some of these remarkable claims arise from undersampling of incomplete geological sections that led to apparent temporal correlations within the relatively coarse resolution capability of Palaeozoic biochronostratigraphy. We examine exceptionally complete sedimentary records from two, low and high, palaeolatitude settings. Their correlation framework reveals a Cenozoic-style scenario including three main glacial cycles and higher-order phenomena. This necessitates revision of mechanisms for the end-Ordovician events, as the first extinction is tied to an early phase of melting, not to initial cooling, and the largest δ13C excursion occurs during final deglaciation, not at the glacial apex

Management of Occupational Manganism: Consensus of an Experts' Panel

Studies and Research Projects / Report R-417, Montréal, IRSST http://www.irsst.qc.ca/en/_publicationirsst_100134.html (Lucchini R was a member of the Expert Panel

CARMA1 is a novel regulator of T-ALL disease and leukemic cell migration to the CNS

No abstract available

Multiple scattering of polarized radiation by non-spherical grains: first results

We present the first numerical radiative transfer simulation of multiple light scattering in dust configurations containing aligned non-spherical (spheroidal) dust grains. Such models are especially important if one wants to explain the circular polarization of light, observed in a variety of astronomical objects. The radiative transfer problem is solved on the basis of the Monte Carlo method. Test simulations, confirming the correct numerical implementation of the scattering mechanism, are presented. As a first application, we investigate the linear and circular polarization of light coming from a spherical circumstellar shell. This shell contains perfectly aligned prolate or oblate spheroidal grains. The most remarkable features of the simulated linear polarization maps are so-called polarization null points where the reversal of polarization occurs. They appear in the case when the grain alignment axis is perpendicular to the line of sight. The maps of circular polarization have a sector-like structure with maxima at the ends of lines inclined to the grain alignment axis by \pm 45\degr.Comment: 13 pages, 14 figures, accepted by A&

Optical turbulence simulations at Mt Graham using the Meso-NH mode

The mesoscale model Meso-NH is used to simulate the optical turbulence at Mt Graham (Arizona, USA), site of the Large Binocular Telescope. Measurements of the CN2-profiles obtained with a generalized scidar from 41 nights are used to calibrate and quantify the model's ability to reconstruct the optical turbulence. The measurements are distributed over different periods of the year, permitting us to study the model's performance in different seasons. A statistical analysis of the simulations is performed for all the most important astroclimatic parameters: the CN2-profiles, the seeing {\epsilon}, the isoplanatic angle {\theta}0 and the wavefront coherence time {\tau}0. The model shows a general good ability in reconstructing the morphology of the optical turbulence (the shape of the vertical distribution of CN2) as well as the strength of all the integrated astroclimatic parameters. The relative error (with respect to measurements) of the averaged seeing on the whole atmosphere for the whole sample of 41 nights is within 9.0 %. The median value of the relative error night by night is equal to 18.7 %, so that the model still maintains very good performances. Comparable percentages are observed in partial vertical slabs (free atmosphere and boundary layer) and in different seasons (summer and winter). We prove that the most urgent problem, at present, is to increase the ability of the model in reconstructing very weak and very strong turbulence conditions in the high atmosphere. This mainly affects the model's performances for the isoplanatic angle predictions, for which the median value of the relative error night by night is equal to 35.1 %. No major problems are observed for the other astroclimatic parameters. A variant to the standard calibration method is tested but we find that it does not provide better results, confirming the solid base of the standard method.Comment: 12 pages, 12 figures. The definitive version can be found at: http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2966.2010.18097.x/abstrac

Effect of oleic acid supplementation on prostaglandin production in maternal endometrial and fetal allantochorion cells isolated from late gestation ewes

Elevated circulating non-esterified fatty acids including oleic acid (OA) are associated with many pregnancy related complications. Prostaglandins (PGs) play crucial roles during parturition. We investigated the effect of OA supplementation on PG production using an in vitro model of ovine placenta

Thermally nucleated magnetic reversal in CoFeB/MgO nanodots

Power consumption is the main limitation in the development of new high performance random access memory for portable electronic devices. Magnetic RAM (MRAM) with CoFeB/MgO based magnetic tunnel junctions (MTJs) is a promising candidate for reducing the power consumption given its non-volatile nature while achieving high performance. The dynamic properties and switching mechanisms of MTJs are critical to understanding device operation and to enable scaling of devices below 30 nm in diameter. Here we show that the magnetic reversal mechanism is incoherent and that the switching is thermally nucleated at device operating temperatures. Moreover, we find an intrinsic thermal switching field distribution arising on the sub-nanosecond time-scale even in the absence of size and anisotropy distributions or material defects. These features represent the characteristic signature of the dynamic properties in MTJs and give an intrinsic limit to reversal reliability in small magnetic nanodevices

Evaluation of the current knowledge limitations in breast cancer research: a gap analysis

BACKGROUND A gap analysis was conducted to determine which areas of breast cancer research, if targeted by researchers and funding bodies, could produce the greatest impact on patients. METHODS Fifty-six Breast Cancer Campaign grant holders and prominent UK breast cancer researchers participated in a gap analysis of current breast cancer research. Before, during and following the meeting, groups in seven key research areas participated in cycles of presentation, literature review and discussion. Summary papers were prepared by each group and collated into this position paper highlighting the research gaps, with recommendations for action. RESULTS Gaps were identified in all seven themes. General barriers to progress were lack of financial and practical resources, and poor collaboration between disciplines. Critical gaps in each theme included: (1) genetics (knowledge of genetic changes, their effects and interactions); (2) initiation of breast cancer (how developmental signalling pathways cause ductal elongation and branching at the cellular level and influence stem cell dynamics, and how their disruption initiates tumour formation); (3) progression of breast cancer (deciphering the intracellular and extracellular regulators of early progression, tumour growth, angiogenesis and metastasis); (4) therapies and targets (understanding who develops advanced disease); (5) disease markers (incorporating intelligent trial design into all studies to ensure new treatments are tested in patient groups stratified using biomarkers); (6) prevention (strategies to prevent oestrogen-receptor negative tumours and the long-term effects of chemoprevention for oestrogen-receptor positive tumours); (7) psychosocial aspects of cancer (the use of appropriate psychosocial interventions, and the personal impact of all stages of the disease among patients from a range of ethnic and demographic backgrounds). CONCLUSION Through recommendations to address these gaps with future research, the long-term benefits to patients will include: better estimation of risk in families with breast cancer and strategies to reduce risk; better prediction of drug response and patient prognosis; improved tailoring of treatments to patient subgroups and development of new therapeutic approaches; earlier initiation of treatment; more effective use of resources for screening populations; and an enhanced experience for people with or at risk of breast cancer and their families. The challenge to funding bodies and researchers in all disciplines is to focus on these gaps and to drive advances in knowledge into improvements in patient care