Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles

Notch is a highly conserved transmembrane protein that is involved in cell fate decisions and is found in organisms ranging from Drosophila to humans. A human homologue of Notch, TAN1, was initially identified at the chromosomal breakpoint of a subset of T-cell lymphoblastic leukemias/lymphomas containing a t(7;9) chromosomal translocation; however, its role in oncogenesis has been unclear. Using a bone marrow reconstitution assay with cells containing retrovirally transduced TAN1 alleles, we analyzed the oncogenic potential of both nuclear and extranuclear forms of truncated TAN1 in hematopoietic cells. Although the Moloney leukemia virus long terminal repeat drives expression in most hematopoietic cell types, retroviruses encoding either form of the TAN1 protein induced clonal leukemias of exclusively immature T cell phenotypes in approximately 50% of transplanted animals. All tumors overexpressed truncated TAN1 of the size and subcellular localization predicted from the structure of the gene. These results show that TAN1 is an oncoprotein and suggest that truncation and overexpression are important determinants of transforming activity. Moreover, the murine tumors caused by TAN1 in the bone marrow transplant model are very similar to the TAN1-associated human tumors and suggest that TAN1 may be specifically oncotropic for T cells

A TV-Gaussian prior for infinite-dimensional Bayesian inverse problems and its numerical implementations

Many scientific and engineering problems require to perform Bayesian inferences in function spaces, in which the unknowns are of infinite dimension. In such problems, choosing an appropriate prior distribution is an important task. In particular we consider problems where the function to infer is subject to sharp jumps which render the commonly used Gaussian measures unsuitable. On the other hand, the so-called total variation (TV) prior can only be defined in a finite dimensional setting, and does not lead to a well-defined posterior measure in function spaces. In this work we present a TV-Gaussian (TG) prior to address such problems, where the TV term is used to detect sharp jumps of the function, and the Gaussian distribution is used as a reference measure so that it results in a well-defined posterior measure in the function space. We also present an efficient Markov Chain Monte Carlo (MCMC) algorithm to draw samples from the posterior distribution of the TG prior. With numerical examples we demonstrate the performance of the TG prior and the efficiency of the proposed MCMC algorithm

Shear velocity structure of central Antarctica from teleseismic Rayleigh waves

第2回極域科学シンポジウム/第31回極域地学シンポジウム 11月16日（水） 国立国語研究

Improved water and land management in the Ethiopian highlands and its impact on downstream stakeholders dependent on the Blue Nile

Improved water and land management in the Ethiopian highlands and its impact on downstream stakeholders dependent on the Blue Nile – short title Upstream-Downstream in Blue Nile River project is one of the projects in the Nile Basin supported by the CPWF. It was implemented during from 2007 to 2009 through a partnership of 8 institutions. The Blue Nile is the major tributary of the Nile River, contributing about 62% of the Nile flow at Aswan. About two thirds of the area of this densely populated basin is in the highlands and hence receives fairly high levels of annual rainfall of 800 to 2,200 mm. However, the rainfall is erratic in terms of both spatial and temporal distribution with prolonged dry spells and drought often leading to crop failures. Currently, water resources are only marginally exploited in the upper basin but are much more developed in the downstream reaches. The population, located in the downstream part of the Blue Nile, is dependent on the river water for supplementary irrigation and energy production. Canal and reservoir siltation is a major problem, adding the burdens of poor riparian farmers. This project was envisaged to improve the scientific understanding of the land and water resources of the basin, and hypothesized that with increased scientific knowledge of the hydrological, watershed, and institutional processes of the Blue Nile in Ethiopia (Abbay), constraints to up-scaling adaptable best practices and promising technologies (technical, socio-economic, institutional) could be overcome, which will result in significant positive impacts for both upstream and downstream communities and state

Ross ice shelf vibrations

Author Posting. © American Geophysical Union, 2015. This article is posted here by permission of American Geophysical Union for personal use, not for redistribution. The definitive version was published in Geophysical Research Letters 42 (2015): 7589–7597, doi:10.1002/2015GL065284.Broadband seismic stations were deployed across the Ross Ice Shelf (RIS) in November 2014 to study ocean gravity wave-induced vibrations. Initial data from three stations 100 km from the RIS front and within 10 km of each other show both dispersed infragravity (IG) wave and ocean swell-generated signals resulting from waves that originate in the North Pacific. Spectral levels from 0.001 to 10 Hz have the highest accelerations in the IG band (0.0025–0.03 Hz). Polarization analyses indicate complex frequency-dependent particle motions, with energy in several frequency bands having distinctly different propagation characteristics. The dominant IG band signals exhibit predominantly horizontal propagation from the north. Particle motion analyses indicate retrograde elliptical particle motions in the IG band, consistent with these signals propagating as Rayleigh-Lamb (flexural) waves in the ice shelf/water cavity system that are excited by ocean wave interactions nearer the shelf front.Bromirski, Diez, and Gerstoft were supported by NSF grant PLR 1246151. Stephen and Bolmer were supported by NSF grant PLR-1246416. Wiens, Aster, and Nyblade were supported under NSF grants PLR-1142518, 1141916, and 1142126, respectively. Bromirski also received support from the California Department of Parks and Recreation, Division of Boating and Waterways under contract 11-106-107. The NIB data were collected under NSF grant OPP-0229546 and were downloaded from the IRIS DMC archives.2016-03-1

Crustal and Upper-mantle Structure Beneath Ice-covered Regions in Antarctica from S-wave Receiver Functions and Implications for Heat Flow

S-wave receiver functions (SRFs) are used to investigate crustal and upper-mantle structure beneath several ice-covered areas of Antarctica. Moho S-to-P (Sp) arrivals are observed at ~6–8 s in SRF stacks for stations in the Gamburtsev Mountains (GAM) and Vostok Highlands (VHIG), ~5–6 s for stations in the Transantarctic Mountains (TAM) and the Wilkes Basin (WILK), and ~3–4 s for stations in the West Antarctic Rift System (WARS) and the Marie Byrd Land Dome (MBLD). A grid search is used to model the Moho Sp conversion time with Rayleigh wave phase velocities from 18 to 30 s period to estimate crustal thickness and mean crustal shear wave velocity. The Moho depths obtained are between 43 and 58 km for GAM, 36 and 47 km for VHIG, 39 and 46 km for WILK, 39 and 45 km for TAM, 19 and 29 km for WARS and 20 and 35 km for MBLD. SRF stacks for GAM, VHIG, WILK and TAM show little evidence of Sp arrivals coming from upper-mantle depths. SRF stacks for WARS and MBLD show Sp energy arriving from upper-mantle depths but arrival amplitudes do not rise above bootstrapped uncertainty bounds. The age and thickness of the crust is used as a heat flow proxy through comparison with other similar terrains where heat flow has been measured. Crustal structure in GAM, VHIG and WILK is similar to Precambrian terrains in other continents where heat flow ranges from ~41 to 58 mW m−2, suggesting that heat flow across those areas of East Antarctica is not elevated. For the WARS, we use the Cretaceous Newfoundland–Iberia rifted margins and the Mesozoic-Tertiary North Sea rift as tectonic analogues. The low-to-moderate heat flow reported for the Newfoundland–Iberia margins (40–65 mW m−2) and North Sea rift (60–85 mW m−2) suggest that heat flow across the WARS also may not be elevated. However, the possibility of high heat flow associated with localized Cenozoic extension or Cenozoic-recent magmatic activity in some parts of the WARS cannot be ruled out

Farmer access to irrigation scheduling advice leads to sustainable intensification of high value crops

United States Agency for International Developmen

Podoconiosis and soil-transmitted helminths (STHs): double burden of neglected tropical diseases in Wolaita zone, rural southern Ethiopia

Background Both podoconiosis and soil-transmitted helminth (STH) infections occur among barefoot people in areas of extreme poverty; however, their co-morbidity has not previously been investigated. We explored the overlap of STH infection and podoconiosis in Southern Ethiopia and quantified their separate and combined effects on prevalent anemia and hemoglobin levels in podoconiosis patients and health controls from the same area. Methods and Principal Findings A two-part comparative cross-sectional study was conducted in Wolaita zone, southern Ethiopia. Data were collected from adult patients presenting with clinically confirmed podoconiosis, and unmatched adult neighborhood controls living in the same administrative area. Information on demographic and selected lifestyle factors was collected using interviewer-administered questionnaires. Stool samples were collected and examined qualitatively using the modified formalin-ether sedimentation method. Hemoglobin level was determined using two different methods: hemoglobinometer and automated hematology analyzer. A total of 913 study subjects (677 podoconiosis patients and 236 controls) participated. The prevalence of any STH infection was 47.6% among patients and 33.1% among controls (p<0.001). The prevalence of both hookworm and Trichuris trichiura infections was significantly higher in podoconiosis patients than in controls (AOR 1.74, 95% CI 1.25 to2.42, AOR 6.53, 95% CI 2.34 to 18.22, respectively). Not wearing shoes and being a farmer remained significant independent predictors of infection with any STH. There was a significant interaction between STH infection and podoconiosis on reduction of hemoglobin level (interaction p value = 0.002). Conclusions Prevalence of any STH and hookworm infection was higher among podoconiosis patients than among controls. A significant reduction in hemoglobin level was observed among podoconiosis patients co-infected with hookworm and ‘non-hookworm STH’. Promotion of consistent shoe-wearing practices may have double advantages in controlling both podoconiosis and hookworm infection in the study area