The flammability of electronic components in spacecraft environments Final report, 15 Mar. - 15 Oct. 1968

Mathematical model for combustion at zero gravity in spacecraft environment

An Interactive Tool to Explore and Improve the Ply Number of Drawings

Given a straight-line drawing $\Gamma$ of a graph $G=(V,E)$, for every vertex $v$ the ply disk $D_v$ is defined as a disk centered at $v$ where the radius of the disk is half the length of the longest edge incident to $v$. The ply number of a given drawing is defined as the maximum number of overlapping disks at some point in $\mathbb{R}^2$. Here we present a tool to explore and evaluate the ply number for graphs with instant visual feedback for the user. We evaluate our methods in comparison to an existing ply computation by De Luca et al. [WALCOM'17]. We are able to reduce the computation time from seconds to milliseconds for given drawings and thereby contribute to further research on the ply topic by providing an efficient tool to examine graphs extensively by user interaction as well as some automatic features to reduce the ply number.Comment: Appears in the Proceedings of the 25th International Symposium on Graph Drawing and Network Visualization (GD 2017

Bandpass Filters on a Modified Multilayer Coplanar Line

The design of compact multilayer coplanar line bandpass filters is presented. These very compact filters make use of the two sides of the substrate of the modified coplanar line. In addition, a transmission zero has been introduced to the filter response, either by extending the metalization under the ground planes, or by employing additional capacitive coupling between the different parts of the filter structure. A good agreement between the simulated and measured responses has been achieved

An Agent-Based Computational Bioeconomic Model of Plant Disease Diffusion and Control: Grapevine Leafroll Disease

WP 2013-11 February 2013JEL Classification Codes: C15; C63; D24; Q1

Transanal total mesorectal excision with triangle rules: a road map to prevent injuries

[Extract] Transanal total mesorectal excision (TaTME) is presented as a promising new surgical technique for the approach to the distal rectum, providing the ability to perform a highquality resection, with technical advantages over the laparoscopic approach. However, the new surgical anatomy of the TaTME resection complicates surgical understanding and increases the risks of inadvertent injuries to important anatomic structures...info:eu-repo/semantics/publishedVersio

Remarks on symplectic circle actions, torsion and loops

We study loops of symplectic diffeomorphisms of closed symplectic manifolds. Our main result, which is valid for a large class of symplectic manifolds, shows that the flux of a symplectic loop vanishes whenever its orbits are contractible. As a consequence, we obtain a new vanishing result for the flux group and new instances where the presence of a fixed point of a symplectic circle action is a sufficient condition for it to be Hamiltonian. We also obtain applications to symplectic torsion, more precisely, non-trivial elements of $\mathrm{Symp}_{0}(M,\omega)$ that have finite order.Comment: 16 page

Evidence for Two Modes of Synergistic Induction of Apoptosis by Mapatumumab and Oxaliplatin in Combination with Hyperthermia in Human Colon Cancer Cells

Colorectal cancer is the third leading cause of cancer-related mortality in the world-- the main cause of death from colorectal cancer is hepatic metastases, which can be treated with isolated hepatic perfusion (IHP). Searching for the most clinically relevant approaches for treating colorectal metastatic disease by isolated hepatic perfusion (IHP), we developed the application of oxaliplatin concomitantly with hyperthermia and humanized death receptor 4 (DR4) antibody mapatumumab (Mapa), and investigated the molecular mechanisms of this multimodality treatment in human colon cancer cell lines CX-1 and HCT116 as well as human colon cancer stem cells Tu-12, Tu-21 and Tu-22. We showed here, in this study, that the synergistic effect of the multimodality treatment-induced apoptosis was caspase dependent and activated death signaling via both the extrinsic apoptotic pathway and the intrinsic pathway. Death signaling was activated by c-Jun N-terminal kinase (JNK) signaling which led to Bcl-xL phosphorylation at serine 62, decreasing the anti-apoptotic activity of Bcl-xL, which contributed to the intrinsic pathway. The downregulation of cellular FLICE inhibitory protein long isoform (c-FLIPL) in the extrinsic pathway was accomplished through ubiquitination at lysine residue (K) 195 and protein synthesis inhibition. Overexpression of c-FLIPL mutant (K195R) and Bcl-xL mutant (S62A) completely abrogated the synergistic effect. The successful outcome of this study supports the application of multimodality strategy to patients with colorectal hepatic metastases who fail to respond to standard chemoradiotherapy that predominantly targets the mitochondrial apoptotic pathway. © 2013 Song et al

First narrow-band search for continuous gravitational waves from known pulsars in advanced detector data

Spinning neutron stars asymmetric with respect to their rotation axis are potential sources of continuous gravitational waves for ground-based interferometric detectors. In the case of known pulsars a fully coherent search, based on matched filtering, which uses the position and rotational parameters obtained from electromagnetic observations, can be carried out. Matched filtering maximizes the signalto- noise (SNR) ratio, but a large sensitivity loss is expected in case of even a very small mismatch between the assumed and the true signal parameters. For this reason, narrow-band analysis methods have been developed, allowing a fully coherent search for gravitational waves from known pulsars over a fraction of a hertz and several spin-down values. In this paper we describe a narrow-band search of 11 pulsars using data from Advanced LIGO’s first observing run. Although we have found several initial outliers, further studies show no significant evidence for the presence of a gravitational wave signal. Finally, we have placed upper limits on the signal strain amplitude lower than the spin-down limit for 5 of the 11 targets over the bands searched; in the case of J1813-1749 the spin-down limit has been beaten for the first time. For an additional 3 targets, the median upper limit across the search bands is below the spin-down limit. This is the most sensitive narrow-band search for continuous gravitational waves carried out so far

On the Hofer-Zehnder conjecture for semipositive symplectic manifolds

We show that, on a closed semipositive symplectic manifold with semisimple quantum homology, any Hamiltonian diffeomorphism possessing more contractible fixed points, counted homologically, than the total Betti number of the manifold, must have infinitely many periodic points. This generalizes to the semipositive setting the beautiful result of Shelukhin on the Hofer-Zehnder conjecture.Comment: 30 page