Working with OpenCL to Speed Up a Genetic Programming Financial Forecasting Algorithm: Initial Results

The genetic programming tool EDDIE has been shown to be a successful financial forecasting tool, however it has suffered from an increase in execution time as new features have been added. Speed is an important aspect in financial problems, especially in the field of algorithmic trading, where a delay in taking a decision could cost millions. To offset this performance loss, EDDIE has been modified to take advantage of multi-core CPUs and dedicated GPUs. This has been achieved by modifying the candidate solution evaluation to use an OpenCL kernel, allowing the parallel evaluation of solutions. Our computational results have shown improvements in the running time of EDDIE when the evaluation was delegated to the OpenCL kernel running on a multi-core CPU, with speed ups up to 21 times faster than the original EDDIE algorithm. While most previous works in the literature reported significantly improvements in performance when running an OpenCL kernel on a GPU device, we did not observe this in our results. Further investigation revealed that memory copying overheads and branching code in the kernel are potentially causes of the (under-)performance of the OpenCL kernel when running on the GPU device

Common parasites of farm animals : their prevention and treatment

Caption title.Digitized 2006 AES MoU

Identification and characterization of a novel extracellular matrix protein nephronectin that is associated with integrin alpha8beta1 in the embryonic kidney.

The epithelial-mesenchymal interactions required for kidney organogenesis are disrupted in mice lacking the integrin alpha8beta1. None of this integrin's known ligands, however, appears to account for this phenotype. To identify a more relevant ligand, a soluble integrin alpha8beta1 heterodimer fused to alkaline phosphatase (AP) has been used to probe blots and cDNA libraries. In newborn mouse kidney extracts, alpha8beta1-AP detects a novel ligand of 70-90 kD. This protein, named nephronectin, is an extracellular matrix protein with five EGF-like repeats, a mucin region containing a RGD sequence, and a COOH-terminal MAM domain. Integrin alpha8beta1 and several additional RGD-binding integrins bind nephronectin. Nephronectin mRNA is expressed in the ureteric bud epithelium, whereas alpha8beta1 is expressed in the metanephric mesenchyme. Nephronectin is localized in the extracellular matrix in the same distribution as the ligand detected by alpha8beta1-AP and forms a complex with alpha8beta1 in vivo. Thus, these results strongly suggest that nephronectin is a relevant ligand mediating alpha8beta1 function in the kidney. Nephronectin is expressed at numerous sites outside the kidney, so it may also have wider roles in development. The approaches used here should be generally useful for characterizing the interactions of novel extracellular matrix proteins identified through genomic sequencing projects

Validated helioseismic inversions for 3-D vector flows

According to time-distance helioseismology, information about internal fluid motions is encoded in the travel times of solar waves. The inverse problem consists of inferring 3-D vector flows from a set of travel-time measurements. Here we investigate the potential of time-distance helioseismology to infer 3-D convective velocities in the near-surface layers of the Sun. We developed a new Subtractive Optimally Localised Averaging (SOLA) code suitable for pipeline pseudo-automatic processing. Compared to its predecessor, the code was improved by accounting for additional constraints in order to get the right answer within a given noise level. The main aim of this study is to validate results obtained by our inversion code. We simulate travel-time maps using a snapshot from a numerical simulation of solar convective flows, realistic Born travel-time sensitivity kernels, and a realistic model of travel-time noise. These synthetic travel times are inverted for flows and the results compared with the known input flow field. Additional constraints are implemented in the inversion: cross-talk minimization between flow components and spatial localization of inversion coefficients. Using modes f, p1 through p4, we show that horizontal convective flow velocities can be inferred without bias, at a signal-to-noise ratio greater than one in the top 3.5 Mm, provided that observations span at least four days. The vertical component of velocity (v_z), if it were to be weak, is more difficult to infer and is seriously affected by cross-talk from horizontal velocity components. We emphasise that this cross-talk must be explicitly minimised in order to retrieve v_z in the top 1 Mm. We also show that statistical averaging over many different areas of the Sun allows for reliably measuring of average properties of all three flow components in the top 5.5 Mm of the convection zone.Comment: 14 pages main paper, 9 pages electronic supplement, 28 figures. Accepted for publication in Astronomy & Astrophysic

An analysis of binocular slant contrast

When a small frontoparallel surface (a test strip) is surrounded by a larger slanted surface (an inducer), the test strip is perceived as slanted in the direction opposite to the inducer. This has been called the depth-contrast effect, but we call it the slant-contrast effect. In nearly all demonstrations of this effect, the inducers slant is specified by stereoscopic signals, and other signals, such as the texture gradient, specify that it is frontoparallel. We present a theory of slant estimation that determines surface slant via linear combination of various slant estimators; the weight of each estimator is proportional to its reliability. The theory explains slant contrast because the absolute slant of the inducer and the relative slant between test strip and inducer are both estimated with greater reliability than the absolute slant of the test strip. The theory predicts that slant contrast will be eliminated if the signals specifying the inducers slant are consistent with one another. It also predicts reversed slant contrast if the inducers slant is specified by nonstereoscopic signals rather than by stereo signals. These predictions were tested and confirmed in three experiments. The first showed that slant contrast is greatly reduced when the stereo- and nonstereo-specified slants of the inducer are made consistent with one another. The second showed that slant contrast is eliminated altogether when the stimulus consists of real planes rather than images on a display screen. The third showed that slant contrast is reversed when the nonstereo-specified slant of the inducer varies and the stereo-specified slant is zero. We conclude that slant contrast is a byproduct of the visual systems reconciliation of conflicting information while it attempts to determine surface slant

Understanding Treatment Burden and Quality of Life Impact of Participating in an Early-Phase Pediatric Oncology Clinical Trial: A Pilot Study

PURPOSE: Early-phase clinical trials (EPTs) have led to new, more effective treatment options for children with cancer. Despite the extensive use of EPTs in pediatric oncology, little is known about parent and child experiences during EPT participation. The purposes of this pilot study were to assess the feasibility and preliminary results of having children with cancer and their parents complete measures of treatment burden and quality of life (QOL) concurrent with EPT participation. METHODS: In this descriptive, longitudinal, pilot study, parents and children were followed for the first 60 days of an EPT. Feasibility was assessed by participant enrollment and retention and completion of measures. Measures completed included the following: demographic form (completed at baseline); Diary of Trial Experiences to capture treatment burden (completed ongoing); and PedsQL™ Quality of Life Inventories, Cancer Modules, and Family Impact Module (completed at baseline, post-first disease evaluation, and off-study). Data were analyzed using descriptive statistics. RESULTS: Feasibility goals of enrollment, retention, and measure completion were partially met. Preliminary treatment burden and QOL results are provided. CONCLUSIONS: While QOL assessments may provide insight into EPT experiences, future studies need to be conducted at multiple sites and enrollment goals must account for participant attrition

Vlasov Equation In Magnetic Field

The linearized Vlasov equation for a plasma system in a uniform magnetic field and the corresponding linear Vlasov operator are studied. The spectrum and the corresponding eigenfunctions of the Vlasov operator are found. The spectrum of this operator consists of two parts: one is continuous and real; the other is discrete and complex. Interestingly, the real eigenvalues are infinitely degenerate, which causes difficulty solving this initial value problem by using the conventional eigenfunction expansion method. Finally, the Vlasov equation is solved by the resolvent method.Comment: 15 page