Invasive bacterial infections in Gambians with sickle cell anaemia in an era of widespread Pneumococcal and Haemophilus influenzae type B vaccination

Background: There is relatively little data on the aetiology of bacterial infections in patients with sickle cell anaemia (SCA) in West Africa, and no data from countries that have implemented conjugate vaccines against both Streptococcus pneumoniae and Haemophilus influenzae type b (Hib). Methods: We conducted a retrospective analysis of SCA patients admitted to the Medical Research Council Unit, The Gambia during a five-year period when there was high coverage of Hib and Pneumococcal conjugate vaccination. We evaluated 161 admissions of 126 patients between April 2010 and April 2015. Results: Pathogenic bacteria were identified in blood cultures from 11 of the 131 admissions that had cultures taken (8.4%, 95% CI 4.5-14.1%). The most frequent isolate was Salmonella Typhimurium (6/11; 54.5%), followed by Staphylococcus aureus (2/11; 18.2%) and other enteric Gram-negative pathogens (2/11; 18.2%) and there was one case of H. influenzae non-type b bacteraemia (1/11; 9.1%). There were no episodes of bacteraemia caused by S. pneumoniae or Hib. Conclusions: The low prevalence of S. pneumoniae and Hib, and the predominance of non-typhoidal Salmonella as a cause of bacteraemia suggest the need to reconsider optimal antimicrobial prophylaxis and the empirical treatment regimens for patients with SCA

Variations in agronomic and grain quality traits of rice grown under irrigated lowland conditions in West Africa

Rice breeding in West Africa has been largely skewed toward yield enhancement and stress tolerance. This has led to the variable grain quality of locally produced rice in the region. This study sought to assess variations in the agronomic and grain quality traits of some rice varieties grown in this region, with a view to identifying sources of high grain yield and quality that could serve as potential donors in their breeding programs. Forty‐five varieties were grown under irrigated conditions in Benin and Senegal with two trials in each country. There were wide variations in agronomic and grain quality traits among the varieties across the trials. Cluster analysis using paddy yield, head rice yield, and chalkiness revealed that 68% of the total variation could be explained by five varietal groupings. One group comprising seven varieties (Afrihikari, BG90‐2, IR64, Sahel 108, WAT311‐WAS‐B‐B‐23‐7‐1, WAT339‐TGR‐5‐2, and WITA 10) had high head rice yield and low chalkiness. Of the varieties in this group, Sahel 108 had the highest paddy yield in three of the four trials. IR64 and Afrihikari had intermediate and low amylose content, respectively, with the rest being high‐amylose varieties. Another group of varieties consisting of B6144F‐MR‐6‐0‐0, C74, IR31851‐96‐2‐3‐2‐1, ITA222, Jaya, Sahel 305, WITA 1, and WITA 2 had high paddy yield but poor head rice yield and chalkiness. The use of materials from these two groups of varieties could accelerate breeding for high yielding rice varieties with better grain quality for local production in West Africa

A four-month gatifloxacin-containing regimen for treating tuberculosis.

BACKGROUND: Shortening the course of treatment for tuberculosis would be a major improvement for case management and disease control. This phase 3 trial assessed the efficacy and safety of a 4-month gatifloxacin-containing regimen for treating rifampin-sensitive pulmonary tuberculosis. METHODS: We conducted a noninferiority, randomized, open-label, controlled trial involving patients 18 to 65 years of age with smear-positive, rifampin-sensitive, newly diagnosed pulmonary tuberculosis in five sub-Saharan African countries. A standard 6-month regimen that included ethambutol during the 2-month intensive phase was compared with a 4-month regimen in which gatifloxacin (400 mg per day) was substituted for ethambutol during the intensive phase and was continued, along with rifampin and isoniazid, during the continuation phase. The primary efficacy end point was an unfavorable outcome (treatment failure, recurrence, or death or study dropout during treatment) measured 24 months after the end of treatment, with a noninferiority margin of 6 percentage points, adjusted for country. RESULTS: A total of 1836 patients were assigned to the 4-month regimen (experimental group) or the standard regimen (control group). Baseline characteristics were well balanced between the groups. At 24 months after the end of treatment, the adjusted difference in the risk of an unfavorable outcome (experimental group [21.0%] minus control group [17.2%]) in the modified intention-to-treat population (1356 patients) was 3.5 percentage points (95% confidence interval, -0.7 to 7.7). There was heterogeneity across countries (P=0.02 for interaction, with differences in the rate of an unfavorable outcome ranging from -5.4 percentage points in Guinea to 12.3 percentage points in Senegal) and in baseline cavitary status (P=0.04 for interaction) and body-mass index (P=0.10 for interaction). The standard regimen, as compared with the 4-month regimen, was associated with a higher dropout rate during treatment (5.0% vs. 2.7%) and more treatment failures (2.4% vs. 1.7%) but fewer recurrences (7.1% vs. 14.6%). There was no evidence of increased risks of prolongation of the QT interval or dysglycemia with the 4-month regimen. CONCLUSIONS: Noninferiority of the 4-month regimen to the standard regimen with respect to the primary efficacy end point was not shown. (Funded by the Special Program for Research and Training in Tropical Diseases and others; ClinicalTrials.gov number, NCT00216385.)

Aménagements hydro-agricoles et santé (vallée du fleuve Sénégal)

Près de 1 500 personnes résidant dans les villages rattachés au périmètre irrigué MO 6bis (périmètre de Diomandou, département de Podor) ont fait l'objet de prélèvements d'urine et/ou de selle afin de déterminer la prévalence de la bilharziose urinaire, de la bilharziose intestinale ainsi que des autres parasitoses entériques. Chez les riverains du périmètre, 1 295 urines ont été examinées, parmi lesquelles sept contenaient des oeufs viables de #Schistosoma haematobium$, ce qui représente un taux de prévalence de 0,5$, ce qui correspond à un indice d'infestation de 0,1%. Il s'agissait là aussi d'un individu dont la contamination avait eu lieu en dehors de la zone d'étude. #Eschirichia coli$est la parasite entérique le plus répandu avec 17,2$, #Strongyloïdes stercoralis, #Ascaris lumbricoïdes et #Trichiuris trichiura$ sont rares et ne concernent qu'un peu moins de 2% des sujets examinés. Ces résultats démontrent l'absence, pour l'instant tout au moins, de foyers de transmission des bilharzioses dans les villages du périmètre de Diomandou. Le risque d'apparition de ces maladies est cependant important et dépend à la fois de l'évolution des infrastructures et de l'éventuelle apparition d'hôtes intermédiaires encore absent du réseau hydrographique de ce périmètre mis en place récemment. (Résumé d'auteur

Species occurrence of cetaceans in Guinea, including humpback whales with southern hemisphere seasonality

An initial inventory of the dolphins and whales occurring in Guinea's coastal waters is documented primarily from specimens and photographic evidence obtained from strandings and by-catches. Seven species are fully validated, four odontocetes, Tursiops truncatus, Sousa teuszii, Stenella frontalis, Kogia breviceps and three balaenopterid whales: Balaenoptera brydei, Balaenoptera acutorostrata and Megaptera novaeangliae. Another three reported species (Globicephala macrorhynchus, Steno bredanensis and Delphinus delphis) are insufficiently supported but thought to be valid. Small cetaceans landed as by-catch and a stranded whale were used for human consumption, but no evidence of substantial takes, directed or by-catch, was found. However, concern is raised about even minimal takes of the vulnerable Atlantic humpback dolphin. The seasonal presence of three confirmed humpback whales, two strandings (July and September) and a sighting (October), is synchronous with the species' southern hemisphere wintering/breeding season in low latitudes. We hypothesize that these whales may comprise the north-westernmost range of the population that breeds/overwinters in coastal waters of the Bight of Benin, northern Gulf of Guinea

Holographic Entanglement Entropy at Finite Temperature

Using a holographic proposal for the entanglement entropy we study its behavior in various supergravity backgrounds. We are particularly interested in the possibility of using the entanglement entropy as way to detect transitions induced by the presence horizons. We consider several geometries with horizons: the black hole in $AdS_3$, nonextremal Dp-branes, dyonic black holes asymptotically to $AdS_4$ and also Schwarzschild black holes in global $AdS_p$ coordinates. Generically, we find that the entanglement entropy does not exhibit a transition, that is, one of the two possible configurations always dominates.Comment: v3: 31 pp, ten figures, modified to match version accepted by IJMP

The cetaceans of Guinea, a first check-list of documented species. Scientific Committee document SC/58/O15, International Whaling Commission, May-June 2006, St. Kitts

A CMS workshop on West African Cetacea (Conakry, May 2000), called for i.a. ‘carrying out .. inventory of cetacean species; collection, treatment and compilation of data for each state.’ The present paper is a preliminary faunal checklist of cetaceans occurring in Guinea’s EEZ. Information was gleaned from strandings, bycatches, scientific and opportunistic sightings and a literature review. Ten species are included for which supporting voucher material and data were available for examination. These are, three baleen whales: Balaenoptera brydei, Balaenoptera acutorostrata and Megaptera novaeangliae; and seven species of odontocetes: Kogia breviceps, Tursiops truncatus, Sousa teuszii, Stenella frontalis, Delphinus delphis, Steno bredanensis and Globicephala macrorhynchus. Another two species, Physeter macrocephalus and Stenella attenuate were sighted off Guinea but no photographic evidence was obtained. The current account is thought to reflect an incomplete picture of Guinea’s cetacean biodiversity. Future surveys are expected to update and investigate spatial and temporal distribution patterns for each species along Guinea’s coast. A few bycatches landed by artisanal fishers were utilised locally, but there are no signs of any substantial captures. Nonetheless, monitoring should be continued. The set-up of a national reference collection and database is recommended. The population identities of the encountered Atlantic humpback dolphin, minke whale and humpback whale are of particular interest

Dipole Coupling Effect of Holographic Fermion in the Background of Charged Gauss-Bonnet AdS Black Hole

We investigate the holographic fermions in the charged Gauss-Bonnet $AdS_{d}$ black hole background with the dipole coupling between fermion and gauge field in the bulk. We show that in addition to the strength of the dipole coupling, the spacetime dimension and the higher curvature correction in the gravity background also influence the onset of the Fermi gap and the gap distance. We find that the higher curvature effect modifies the fermion spectral density and influences the value of the Fermi momentum for the appearance of the Fermi surface. There are richer physics in the boundary fermion system due to the modification in the bulk gravity.Comment: 16 pages, accepted for publication in JHE