Infusing Problem-Based Learning (PBL) Into Science Methods Courses Across Virginia

This article outlines the results of a collaborative study of the effects of infusing problem-based learning (PBL) into K-12 science methods courses across four universities in Virginia. Changes in pre-service teachers\u27 attitudes surrounding science teaching were measured before and after completing a science methods course in which they experienced PBL first-hand as participants, and then practiced designing their own PBL units for use in their future classrooms. The results indicate that exposure to PBL enhances pre-service teachers\u27 knowledge of inquiry methods and self-efficacy in teaching science

Promoting responsibility, shaping behaviour: housing management, mixed communities and the construction of citizenship

This article examines housing policies aimed at establishing mixed income communities. Based on stakeholder interviews and case study analysis in England and Scotland, the article pays particular attention to the impact of interventions in housing management. The first part of the article considers the policy context for mixed communities and considers the conceptual basis underlying contemporary housing management through discourses of culture and social control. The second part considers how this agenda has resulted in the adoption of intensive management strategies within mixed communities; illustrated in the development of allocation policies, initiatives designed to tackle anti-social behaviour and proposals to develop sustainable communities. The main argument is given that the concept of mixed communities is based on the premise of social housing failure, citizenship has been defined largely in response to private sector interests. This approach to management has been a contributory factor in the construction of social housing as a form of second-class citizenship

SalmoNet, an integrated network of ten Salmonella enterica strains reveals common and distinct pathways to host adaptation

Salmonella enterica is a prominent bacterial pathogen with implications on human and animal health. Salmonella serovars could be classified as gastro-intestinal or extra-intestinal. Genome-wide comparisons revealed that extra-intestinal strains are closer relatives of gastro-intestinal strains than to each other indicating a parallel evolution of this trait. Given the complexity of the differences, a systems-level comparison could reveal key mechanisms enabling extra-intestinal serovars to cause systemic infections. Accordingly, in this work, we introduce a unique resource, SalmoNet, which combines manual curation, high-throughput data and computational predictions to provide an integrated network for Salmonella at the metabolic, transcriptional regulatory and protein-protein interaction levels. SalmoNet provides the networks separately for five gastro-intestinal and five extra-intestinal strains. As a multi-layered, multi-strain database containing experimental data, SalmoNet is the first dedicated network resource for Salmonella. It comprehensively contains interactions between proteins encoded in Salmonella pathogenicity islands, as well as regulatory mechanisms of metabolic processes with the option to zoom-in and analyze the interactions at specific loci in more detail. Application of SalmoNet is not limited to strain comparisons as it also provides a Salmonella resource for biochemical network modeling, host-pathogen interaction studies, drug discovery, experimental validation of novel interactions, uncovering new pathological mechanisms from emergent properties and epidemiological studies. SalmoNet is available at http://salmonet.org

Conserved genes and pathways in primary human fibroblast strains undergoing replicative and radiation induced senescence

Additional file 3: Figure S3. Regulation of genes of Arrhythmogenic right ventricular cardiomyopathy pathway during senescence induction in HFF strains Genes of the “Arrhythmogenic right ventricular cardiomyopathy” pathway which are significantly up- (green) and down- (red) regulated (log2 fold change >1) during irradiation induced senescence (120 h after 20 Gy irradiation) in HFF strains. Orange color signifies genes which are commonly up-regulated during both, irradiation induced and replicative senescence

PCB pollution continues to impact populations of orcas and other dolphins in European waters

Organochlorine (OC) pesticides and the more persistent polychlorinated biphenyls (PCBs) have well-established dose-dependent toxicities to birds, fish and mammals in experimental studies, but the actual impact of OC pollutants on European marine top predators remains unknown. Here we show that several cetacean species have very high mean blubber PCB concentrations likely to cause population declines and suppress population recovery. In a large pan-European meta-analysis of stranded (n = 929) or biopsied (n = 152) cetaceans, three out of four species:- striped dolphins (SDs), bottlenose dolphins (BNDs) and killer whales (KWs) had mean PCB levels that markedly exceeded all known marine mammal PCB toxicity thresholds. Some locations (e.g. western Mediterranean Sea, south-west Iberian Peninsula) are global PCB "hotspots" for marine mammals. Blubber PCB concentrations initially declined following a mid-1980s EU ban, but have since stabilised in UK harbour porpoises and SDs in the western Mediterranean Sea. Some small or declining populations of BNDs and KWs in the NE Atlantic were associated with low recruitment, consistent with PCB-induced reproductive toxicity. Despite regulations and mitigation measures to reduce PCB pollution, their biomagnification in marine food webs continues to cause severe impacts among cetacean top predators in European seas

“Moving with the story”: the haptics of reader experience and response to digital comics

The experience of reading digital comics differs from that of other reading in that it involves the interplay between text and art, both “on the page”, for example, as with the traditional comic book format, or “off the page” in interaction with devices, apps and “extras” the Alt Text in the webcomic, xkcd. This interplay and placement can communicate movement, stillness, suspense, bringing the reader along not only through content or story arc but also through the material affordances, the physical reality of the comic in combination with the technology. The findings of this exploratory study reveal both the varied reading experiences of digital comics as well as the shared experiences of haptic interactions and emotional perception and reaction through the use of devices, comics platforms and apps, and social media. Although webcomics, one type of digital comics, have long been a part of the evolution of hypertext, their place has not always been acknowledged in the scholarship. This research not only contributes towards an empirical, qualitative understanding of reader response to and experience of a range of digital comics including webcomics, but also addresses their role as an example of the haptics of hypertext fiction

"Webcomics Archive? Now I'm Interested": Comics Readers Seeking Information in Web Archives (Poster)

There is a longstanding tradition of understanding information needs and interaction behavior across different user groups to inform the design of digital products and services. There is a gap in such research of comics readers, specifically how they seek and interact with the information and interfaces of web-based archives provided by cultural institutions. For example, while information interaction research has now recognized that information-seeking for leisure and pleasure are important domains of study - consuming information based in fiction can help us escape to exciting worlds by captivating narratives - and while there have been studies of how people find fiction to read, there have to our knowledge been no user-centered studies on how people find and consume digital comics. This exploratory study provides an enriched understanding of the information needs and interaction behaviors of digital comics readers and how that understanding can inform the design of digital platforms to better support them

“Webcomics Archive? Now I’m Interested”: Comics Readers Seeking Information in Web Archives

There is a longstanding tradition of understanding information needs and interaction behavior across different user groups to inform the design of digital products and services. There is a gap in such research of comics readers, specifically how they seek and interact with the information and interfaces of web-based archives provided by cultural institutions. For example, while information interaction research has now recognized that information-seeking for leisure and pleasure are important domains of study - consuming information based in fiction can help us escape to exciting worlds by captivating narratives - and while there have been studies of how people find fiction to read, there have to our knowledge been no user-centered studies on how people find and consume digital comics. This exploratory study provides an enriched understanding of the information needs and interaction behaviors of digital comics readers and how that understanding can inform the design of digital platforms to better support them