Functionals in stochastic thermodynamics: how to interpret stochastic integrals

In stochastic thermodynamics standard concepts from macroscopic thermodynamics, such as heat, work, and entropy production, are generalized to small fluctuating systems by defining them on a trajectory-wise level. In Langevin systems with continuous state-space such definitions involve stochastic integrals along system trajectories, whose specific values depend on the discretization rule used to evaluate them (i.e. the 'interpretation' of the noise terms in the integral). Via a systematic mathematical investigation of this apparent dilemma, we corroborate the widely used standard interpretation of heat-and work-like functionals as Stratonovich integrals. We furthermore recapitulate the anomalies that are known to occur for entropy production in the presence of temperature gradients

DARCOF II. Danish research in Organic Food and Farming systems 2000-2005

The aim of this book is to present a comprehensive overview of the 41 research projects undertaken in the period 2000-2005 in the research programme DARCOF II.For each project there is a description of its background and objective in terms of which issues gave rise to the project and what the project aims to achieve. This is followed by a short description of the experiments or investigations that have been undertaken in the project. The general and applicable results derived from the project are finally described. For each project there is a reference to a project home page on www.darcof.dk. Via this page there is direct access to "Organic Eprints", which is the site containing all the project publications – both technical and scientific

Proton spin in a light-cone chiral quark model

We discuss the spin structure of the proton in a light-cone treatment of the chiral quark model. Based on the fact that the quark helicity ($\Delta q$) measured in polarized deep inelastic scattering experiments is actually the quark spin defined in the light-cone formalism, rather than the quark spin ($\Delta q_{QM}$) defined in the conventionally quark model (or in the rest frame of the nucleon), we calculate the $x$-dependence of the polarized quark distribution functions $\Delta q(x)$, and the polarized structure functions $g_1 (x)$. Special attention is focused on the Melosh-Wigner rotation due to the transversal motions of quarks inside the nucleon and its effects on the bare quark input. It is shown that our results match the experimental data well.Comment: 11 latex pages, 8 figures, final version published in PR

Beyond Concurrent Chemoradiation: The Emerging Role of PD-1/PD-L1 Inhibitors in Stage III Lung Cancer.

Concurrent chemoradiation (cCRT) with platinum-based chemotherapy is standard-of-care therapy for patients with stage III unresectable non-small cell lung cancer (NSCLC). Although cCRT is potentially curative, 5-year overall survival has hovered around 20%, despite extensive efforts to improve outcomes with increasing doses of conformal radiation and intensification of systemic therapy with either induction or consolidation chemotherapy. PD-1/PD-L1 immune checkpoint inhibitors have demonstrated unprecedented efficacy in patients with stage IV NSCLC. In addition, preclinical and early clinical evidence suggests that chemotherapy and radiation may work synergistically with anti-PD-1/PD-L1 therapy to promote antitumor immunity, which has led to the initiation of clinical trials testing these drugs in patients with stage III NSCLC. A preliminary report of a randomized phase III trial, the PACIFIC trial, demonstrated an impressive increase in median progression-free survival with consolidative durvalumab, a PD-L1 inhibitor, compared with observation after cCRT. Here, we discuss the clinical and translational implications of integrating PD-1/PD-L1 inhibitors in the management of patients with unresectable stage III NSCLC

Cool transition region loops observed by the Interface Region Imaging Spectrograph

We report on the first Interface Region Imaging Spectrograph (IRIS) study of cool transition region loops. This class of loops has received little attention in the literature. A cluster of such loops was observed on the solar disk in active region NOAA11934, in the Si IV 1402.8 \AA\ spectral raster and 1400 \AA\ slit-jaw (SJ) images. We divide the loops into three groups and study their dynamics and interaction. The first group comprises relatively stable loops, with 382--626\,km cross-sections. Observed Doppler velocities are suggestive of siphon flows, gradually changing from -10 km/s at one end to 20 km/s at the other end of the loops. Nonthermal velocities from 15 to 25 km/s were determined. These physical properties suggest that these loops are impulsively heated by magnetic reconnection occurring at the blue-shifted footpoints where magnetic cancellation with a rate of $10^{15}$ Mx/s is found. The released magnetic energy is redistributed by the siphon flows. The second group corresponds to two footpoints rooted in mixed-magnetic-polarity regions, where magnetic cancellation occurred at a rate of $10^{15}$ Mx/s and line profiles with enhanced wings of up to 200 km/s were observed. These are suggestive of explosive-like events. The Doppler velocities combined with the SJ images suggest possible anti-parallel flows in finer loop strands. In the third group, interaction between two cool loop systems is observed. Evidence for magnetic reconnection between the two loop systems is reflected in the line profiles of explosive events, and a magnetic cancellation rate of $3\times10^{15}$ Mx/s observed in the corresponding area. The IRIS observations have thus opened a new window of opportunity for in-depth investigations of cool transition region loops. Further numerical experiments are crucial for understanding their physics and their role in the coronal heating processes.Comment: Accepted for publication in Ap

Robust variance-constrained filtering for a class of nonlinear stochastic systems with missing measurements

The official published version of the article can be found at the link below.This paper is concerned with the robust filtering problem for a class of nonlinear stochastic systems with missing measurements and parameter uncertainties. The missing measurements are described by a binary switching sequence satisfying a conditional probability distribution, and the nonlinearities are expressed by the statistical means. The purpose of the filtering problem is to design a filter such that, for all admissible uncertainties and possible measurements missing, the dynamics of the filtering error is exponentially mean-square stable, and the individual steady-state error variance is not more than prescribed upper bound. A sufficient condition for the exponential mean-square stability of the filtering error system is first derived and an upper bound of the state estimation error variance is then obtained. In terms of certain linear matrix inequalities (LMIs), the solvability of the addressed problem is discussed and the explicit expression of the desired filters is also parameterized. Finally, a simulation example is provided to demonstrate the effectiveness and applicability of the proposed design approach.This work was supported in part by the Engineering and Physical Sciences Research Council (EPSRC) of the UK under Grant GR/S27658/01, the Royal Society of the UK and the Alexander von Humboldt Foundation of Germany

Systematic prioritization of considerations in making offshore software development outsourcing decisions

Thesis (M. Eng.)--Massachusetts Institute of Technology, Dept. of Electrical Engineering and Computer Science, 2005.Includes bibliographical references (leaves 43-45).Offshore outsourcing of software development projects has become increasingly prevalent over the past decade. In order to avoid potential pitfalls in outsourcing, companies must carefully select who to outsource to. Although general guidelines exist for those companies to consult, they are not customizable to the unique needs of each company and project. By assessing the type of a company's outsourceable project and its in-house capabilities regarding the project, the main outsourcing goal of the company is first determined. Depending on the goal, the essential issues to be considered in making outsourcing decisions are then prioritized systematically. Case studies have been conducted to support the set prioritization patterns, followed by an examination of current limitations and possible future work.by Bo S. Kim.M.Eng