The economic impact of the Budapest Airport on the local economy

Airports have an unquestionably dominant role in the transport of the 21st century; air transport is the heart of the modern, globalised economy. Beyond this primary function, the international literature also emphasises the considerable economic and economy development effects of airports. The significant airports of the world not only facilitate the local economy but fundamentally determine that. The aim of the analysis is not only the study of the economic impact of the Budapest Ferihegy International Airport, but also examining the economic impact of the complex system of the companies operating at the airport and complementing each other. First of all, we discuss the methods and concepts to be applied in the analysis of the economic impact of the Budapest Airport. Although the methods and the terminology is fairly uniform in the course of the general review studies, the actual pieces of research can mean something different by the same concepts or they may examine the same thing with different concepts.

Longitudinal Tomographic Reconstruction of LHC-type Bunches in the SPS

Longitudinal tomographic reconstruction on the basis of measured profiles is an important technique to measure the particle density distribution of a bunch in longitudinal phase space. This measurement technique, well established in all circular machines of the PS complex, has been applied to the SPS for the first time. Due to recent improvements of the data acquisition of the signals from the longitudinal pick-ups in the SPS and a new LHC type wall current monitor, the quality of the bunch profiles is now more appropriate for tomography. Longitudinal beam signals from the wall current pick-ups APWL-10 and WC-2 are used as input for the reconstruction algorithm. It is shown that, due to short bunches and long cables in the SPS, the correction of the signal with the transfer function of the transmission system is indispensable. The analysis of the longitudinal distribution of a batch of 48 bunches of an LHC type beam at injection into the SPS, averaged over more than ten cycles, showed that any systematic variation of the bunch parameters along the batch is shadowed by statistical errors due to the quality of the measured bunch profiles. Avoiding the long coaxial cables from the SPS tunnel to the surface is a crucial issue for improving the quality of the bunch profiles suitable for tomographic reconstruction

Serendipitous Discovery of Light-Induced \u3cem\u3e(In Situ)\u3c/em\u3e Formation of An Azo-Bridged Dimeric Sulfonated Naphthol as a Potent PTP1B Inhibito

Background Protein tyrosine phosphatases (PTPs) like dual specificity phosphatase 5 (DUSP5) and protein tyrosine phosphatase 1B (PTP1B) are drug targets for diseases that include cancer, diabetes, and vascular disorders such as hemangiomas. The PTPs are also known to be notoriously difficult targets for designing inihibitors that become viable drug leads. Therefore, the pipeline for approved drugs in this class is minimal. Furthermore, drug screening for targets like PTPs often produce false positive and false negative results. Results Studies presented herein provide important insights into: (a) how to detect such artifacts, (b) the importance of compound re-synthesis and verification, and (c) how in situ chemical reactivity of compounds, when diagnosed and characterized, can actually lead to serendipitous discovery of valuable new lead molecules. Initial docking of compounds from the National Cancer Institute (NCI), followed by experimental testing in enzyme inhibition assays, identified an inhibitor of DUSP5. Subsequent control experiments revealed that this compound demonstrated time-dependent inhibition, and also a time-dependent change in color of the inhibitor that correlated with potency of inhibition. In addition, the compound activity varied depending on vendor source. We hypothesized, and then confirmed by synthesis of the compound, that the actual inhibitor of DUSP5 was a dimeric form of the original inhibitor compound, formed upon exposure to light and oxygen. This compound has an IC50 of 36 μM for DUSP5, and is a competitive inhibitor. Testing against PTP1B, for selectivity, demonstrated the dimeric compound was actually a more potent inhibitor of PTP1B, with an IC50 of 2.1 μM. The compound, an azo-bridged dimer of sulfonated naphthol rings, resembles previously reported PTP inhibitors, but with 18-fold selectivity for PTP1B versus DUSP5. Conclusion We report the identification of a potent PTP1B inhibitor that was initially identified in a screen for DUSP5, implying common mechanism of inhibitory action for these scaffolds

Curvature-direction measures of self-similar sets

We obtain fractal Lipschitz-Killing curvature-direction measures for a large class of self-similar sets F in R^d. Such measures jointly describe the distribution of normal vectors and localize curvature by analogues of the higher order mean curvatures of differentiable submanifolds. They decouple as independent products of the unit Hausdorff measure on F and a self-similar fibre measure on the sphere, which can be computed by an integral formula. The corresponding local density approach uses an ergodic dynamical system formed by extending the code space shift by a subgroup of the orthogonal group. We then give a remarkably simple proof for the resulting measure version under minimal assumptions.Comment: 17 pages, 2 figures. Update for author's name chang

Piecewise Linear Models for the Quasiperiodic Transition to Chaos

We formulate and study analytically and computationally two families of piecewise linear degree one circle maps. These families offer the rare advantage of being non-trivial but essentially solvable models for the phenomenon of mode-locking and the quasi-periodic transition to chaos. For instance, for these families, we obtain complete solutions to several questions still largely unanswered for families of smooth circle maps. Our main results describe (1) the sets of maps in these families having some prescribed rotation interval; (2) the boundaries between zero and positive topological entropy and between zero length and non-zero length rotation interval; and (3) the structure and bifurcations of the attractors in one of these families. We discuss the interpretation of these maps as low-order spline approximations to the classic ``sine-circle'' map and examine more generally the implications of our results for the case of smooth circle maps. We also mention a possible connection to recent experiments on models of a driven Josephson junction.Comment: 75 pages, plain TeX, 47 figures (available on request

A Metric Discrepancy Result With Given Speed

It is known that the discrepancy DN{ kx} of the sequence { kx} satisfies NDN{ kx} = O((log N) (log log N) 1 + ε) a.e. for all ε> 0 , but not for ε= 0. For nk= θk, θ> 1 we have NDN{ nkx} ≦ (Σ θ+ ε) (2 Nlog log N) 1 / 2 a.e. for some 0 0 , but not for ε 0 , there exists a sequence { nk} of positive integers such that NDN{ nkx} ≦ (Σ + ε) Ψ (N) eventually holds a.e. for ε> 0 , but not for ε< 0. We also consider a similar problem on the growth of trigonometric sums. © 2016, Akadémiai Kiadó, Budapest, Hungary

Identification of inhibitors that target dual-specificity phosphatase 5 provide new insights into the binding requirements for the two phosphate pockets

Background: Dual-specificity phosphatase-5 (DUSP5) plays a central role in vascular development and disease. We present a p-nitrophenol phosphate (pNPP) based enzymatic assay to screen for inhibitors of the phosphatase domain of DUSP5. Methods: pNPP is a mimic of the phosphorylated tyrosine on the ERK2 substrate (pERK2) and binds the DUSP5 phosphatase domain with a Km of 7.6 ± 0.4 mM. Docking followed by inhibitor verification using the pNPP assay identified a series of polysulfonated aromatic inhibitors that occupy the DUSP5 active site in the region that is likely occupied by the dual-phosphorylated ERK2 substrate tripeptide (pThr-Glu-pTyr). Secondary assays were performed with full length DUSP5 with ERK2 as substrate. Results: The most potent inhibitor has a naphthalene trisulfonate (NTS) core. A search for similar compounds in a drug database identified suramin, a dimerized form of NTS. While suramin appears to be a potent and competitive inhibitor (25 ± 5 μM), binding to the DUSP5 phosphatase domain more tightly than the monomeric ligands of which it is comprised, it also aggregates. Further ligand-based screening, based on a pharmacophore derived from the 7 Å separation of sulfonates on inhibitors and on sulfates present in the DUSP5 crystal structure, identified a disulfonated and phenolic naphthalene inhibitor (CSD3 _2320) with IC50 of 33 μM that is similar to NTS and does not aggregate. Conclusions: The new DUSP5 inhibitors we identify in this study typically have sulfonates 7 Å apart, likely positioning them where the two phosphates of the substrate peptide (pThr-Glu-pTyr) bind, with one inhibitor also positioning a phenolic hydroxyl where the water nucleophile may reside. Polysulfonated aromatic compounds do not commonly appear in drugs and have a tendency to aggregate. One FDA-approved polysulfonated drug, suramin, inhibits DUSP5 and also aggregates. Docking and modeling studies presented herein identify polysulfonated aromatic inhibitors that do not aggregate, and provide insights to guide future design of mimics of the dual-phosphate loops of the ERK substrates for DUSPs. Keywords: DUSP5, Phosphatase, Drug discovery, Docking, Suramin, Vascular anomalie

Transverse Impedance of LHC Collimators

The transverse impedance in the LHC is expected to be dominated by the numerous collimators, most of which are made of Fibre-Reinforced-Carbon to withstand the impacts of high intensity proton beams in case of failures, and which will be moved very close to the beam, with full gaps of few millimetres, in order to protect surrounding super-conducting equipments. We present an estimate of the transverse resistive-wall impedance of the LHC collimators, the total impedance in the LHC at injection and top energy, the induced coupled-bunch growth rates and tune shifts, and finally the result of the comparison of the theoretical predictions with measurements performed in 2004 and 2006 on a prototype collimator installed in the SPS

First Results for the Beam Commissioning of the CERN Multi-Turn Extraction

The Multi-Turn Extraction (MTE), a new type of extraction based on beam trapping inside stable islands in horizontal phase space, has been commissioned during the 2008 run of the CERN Proton Synchrotron. Both singleand multi-bunch beams with a total intensity up to 1.4 1013 protons have been extracted with efficiencies up to 98%. Furthermore, injection tests in the CERN Super Proton Synchrotron were performed, with the beam then accelerated and extracted to produce neutrinos for the CERN Neutrino-to-Gran Sasso experiments. The results of the extensive measurement campaign are presented and discussed in detail