Evaluation of the usefulness of a computer‐based learning program to support student learning in pharmacology

This study aims to evaluate the effectiveness of a computer‐based teaching program in supporting and enhancing traditional teaching methods. The program covers the pharmacology of inflammation and has been evaluated with a group of second‐year medical students at a UK university. The study assessed subject‐specific knowledge using a pre‐ and post‐test and surveyed, by questionnaire, students’ perceptions of the usefulness of the program to support learning before and after use. The use of computers for learning amongst this cohort of students was widespread. The results demonstrated an increase in students ‘ knowledge of the pharmacology of inflammation, coupled with a positive attitude towards the CBL program they had used and the advantages that this mode of study may provide in enabling students to manage their own learning. However, students did not feel that the program could substitute for traditional teaching (lectures)

The ADHM Construction of Instantons on Noncommutative Spaces

We present an account of the ADHM construction of instantons on Euclidean space-time $\mathbb{R}^4$ from the point of view of noncommutative geometry. We recall the main ingredients of the classical construction in a coordinate algebra format, which we then deform using a cocycle twisting procedure to obtain a method for constructing families of instantons on noncommutative space-time, parameterised by solutions to an appropriate set of ADHM equations. We illustrate the noncommutative construction in two special cases: the Moyal-Groenewold plane $\mathbb{R}^4_\hbar$ and the Connes-Landi plane $\mathbb{R}^4_\theta$.Comment: Latex, 40 page

Differential and Twistor Geometry of the Quantum Hopf Fibration

We study a quantum version of the SU(2) Hopf fibration $S^7 \to S^4$ and its associated twistor geometry. Our quantum sphere $S^7_q$ arises as the unit sphere inside a q-deformed quaternion space $\mathbb{H}^2_q$. The resulting four-sphere $S^4_q$ is a quantum analogue of the quaternionic projective space $\mathbb{HP}^1$. The quantum fibration is endowed with compatible non-universal differential calculi. By investigating the quantum symmetries of the fibration, we obtain the geometry of the corresponding twistor space $\mathbb{CP}^3_q$ and use it to study a system of anti-self-duality equations on $S^4_q$, for which we find an `instanton' solution coming from the natural projection defining the tautological bundle over $S^4_q$.Comment: v2: 38 pages; completely rewritten. The crucial difference with respect to the first version is that in the present one the quantum four-sphere, the base space of the fibration, is NOT a quantum homogeneous space. This has important consequences and led to very drastic changes to the paper. To appear in CM

Simulated kinetic effects of the corona and solar cycle on high altitude ion transport at Mars

Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/99008/1/jgra50358.pd

Single-chain factor XII exhibits activity when complexed to polyphosphate

© 2014 The Authors. Journal of Thrombosis and Haemostasis published by Wiley Periodicals, Inc. on behalf of International Society on Thrombosis and Haemostasis.Peer reviewedPublisher PD

Quantisation of twistor theory by cocycle twist

We present the main ingredients of twistor theory leading up to and including the Penrose-Ward transform in a coordinate algebra form which we can then `quantise' by means of a functorial cocycle twist. The quantum algebras for the conformal group, twistor space CP^3, compactified Minkowski space CMh and the twistor correspondence space are obtained along with their canonical quantum differential calculi, both in a local form and in a global *-algebra formulation which even in the classical commutative case provides a useful alternative to the formulation in terms of projective varieties. We outline how the Penrose-Ward transform then quantises. As an example, we show that the pull-back of the tautological bundle on CMh pulls back to the basic instanton on S^4\subset CMh and that this observation quantises to obtain the Connes-Landi instanton on \theta-deformed S^4 as the pull-back of the tautological bundle on our \theta-deformed CMh. We likewise quantise the fibration CP^3--> S^4 and use it to construct the bundle on \theta-deformed CP^3 that maps over under the transform to the \theta-deformed instanton.Comment: 68 pages 0 figures. Significant revision now has detailed formulae for classical and quantum CP^

Efficacy, Safety, and Timing of Anticoagulant Thromboprophylaxis for the Prevention of Venous Thromboembolism in Patients With Acute Spinal Cord Injury: A Systematic Review

Study Design: Systematic review. Objectives: The objective of this study was to answer 5 key questions: What is the comparative effectiveness and safety of (1a) anticoagulant thromboprophylaxis compared to no prophylaxis, placebo, or another anticoagulant strategy for preventing deep vein thrombosis (DVT) and pulmonary embolism (PE) after acute spinal cord injury (SCI)? (1b) Mechanical prophylaxis strategies alone or in combination with other strategies for preventing DVT and PE after acute SCI? (1c) Prophylactic inferior vena cava filter insertion alone or in combination with other strategies for preventing DVT and PE after acute SCI? (2) What is the optimal timing to initiate and/or discontinue anticoagulant, mechanical, and/or prophylactic inferior vena cava filter following acute SCI? (3) What is the cost-effectiveness of these treatment options? Methods: A systematic literature search was conducted to identify studies published through February 28, 2015. We sought randomized controlled trials evaluating efficacy and safety of antithrombotic strategies. Strength of evidence was evaluated using the Grading of Recommendations Assessment, Development and Evaluation (GRADE) system. Results: Nine studies satisfied inclusion criteria. We found a trend toward lower risk of DVT in patients treated with enoxaparin. There were no significant differences in rates of DVT, PE, bleeding, and mortality between patients treated with different types of low-molecular-weight heparin or between low-molecular-weight heparin and unfractionated heparin. Combined anticoagulant and mechanical prophylaxis initiated within 72 hours of SCI resulted in lower risk of DVT than treatment commenced after 72 hours of injury. Conclusion: Prophylactic treatments can be used to lower the risk of venous thromboembolic events in patients with acute SCI, without significant increase in risk of bleeding and mortality and should be initiated within 72 hours. © 2017, © The Author(s) 2017

Offenders' Crime Narratives across Different Types of Crimes

The current study explores the roles offenders see themselves playing during an offence and their relationship to different crime types. One hundred and twenty incarcerated offenders indicated the narrative roles they acted out whilst committing a specific crime they remembered well. The data were subjected to Smallest Space Analysis (SSA) and four themes were identified: Hero, Professional, Revenger and Victim in line with the recent theoretical framework posited for Narrative Offence Roles (Youngs & Canter, 2012). Further analysis showed that different subsets of crimes were more like to be associated with different narrative offence roles. Hero and Professional were found to be associated with property offences (theft, burglary and shoplifting), drug offences and robbery and Revenger and Victim were found to be associated with violence, sexual offences and murder. The theoretical implications for understanding crime on the basis of offenders' narrative roles as well as practical implications are discussed

Coastal cliff ground motions and response to extreme storm waves

Coastal cliff erosion from storm waves is observed worldwide, but the processes are notoriously difficult to measure during extreme storm wave conditions when most erosion normally occurs, limiting our understanding of cliff processes. Over January–February 2014, during the largest Atlantic storms in at least 60 years with deepwater significant wave heights of 6–8 m, cliff-top ground motions showed vertical ground displacements in excess of 50–100 µm; an order of magnitude larger than observations made previously. Repeat terrestrial laser scanner surveys over a 2 week period encompassing the extreme storms gave a cliff face volume loss of 2 orders of magnitude larger than the long-term erosion rate. The results imply that erosion of coastal cliffs exposed to extreme storm waves is highly episodic and that long-term rates of cliff erosion will depend on the frequency and severity of extreme storm wave impacts

A Survey of Satisfiability Modulo Theory

Satisfiability modulo theory (SMT) consists in testing the satisfiability of first-order formulas over linear integer or real arithmetic, or other theories. In this survey, we explain the combination of propositional satisfiability and decision procedures for conjunctions known as DPLL(T), and the alternative "natural domain" approaches. We also cover quantifiers, Craig interpolants, polynomial arithmetic, and how SMT solvers are used in automated software analysis.Comment: Computer Algebra in Scientific Computing, Sep 2016, Bucharest, Romania. 201