Impacts of technological interventions on fish production and biodiversity of seasonal floodplains in Bangladesh

The Community-based Fish Culture in Seasonal Floodplains and Irrigation Systems (CBFC) project is a five year research project supported by the Challenge Program on Water and Food (CPWF), with the aim of increasing productivity of seasonally occurring water bodies through aquaculture. The project has been implemented in Bangladesh, Cambodia, China, Mali and Vietnam, where technical and institutional options for community based aquaculture have been tested. The project began in 2005 and was completed in March 2010. The objective of the study was to determine the impacts of technological interventions in the floodplains on fish yield and biodiversity benefiting the poor fisher folk and other community people. Technological interventions for fish culture in the floodplains included (a) the installation of low-cost large meshed bamboo fencing at water inlet and outlet points, and setting of ring culverts for maintaining suitable levels of water for fish culture without hampering the production of rice in the upland areas of the floodplains (b) stocking of larger fingerlings at suitable stocking densities of endemic (rohu, catla, mrigal) and exotic (silver carp, bighead carp, common carp/mirror carp) species at 31-48 kg/ha (c) post stocking management; use of extra fencing during over flooding and mobile guarding using boats (d) harvesting management; regulations in harvest for certain period, use of multiple harvesting techniques. These interventions were carried out through CB participation with initial technological and financial support from the Challenge Program Project (CP35).Flood plains, Freshwater aquaculture

CPWF publication policies and guidelines: Version 1.2

The Challenge Program on Water and Food (CPWF) was launched in 2002 as a reform initiative of the Consultative Group on International Agricultural Research (CGIAR). The CPWF aims to increase the resilience of social and ecological systems through better water management for food production (crops, fisheries, and livestock). Since 2002, the program has evolved from a range of research projects to an integrated research program that focuses on specific development challenges in six river basins around the world: Andes, Ganges, Limpopo, Mekong, Nile and Volta. Publishing and documenting research is an important part of the research for development process. It is increasingly recognized that interim results can be important for development practitioners and that communication strategies need to be integrated from the beginning of the research process rather than seen as a by-­‐product For this reason, the CPWF strongly encourages the publication of research results, both intermediary and final. It is important to share the CPWF's findings and demonstrate our achievements to our stakeholders, extension agents, donors, policy makers, and other researchers.The guidelines should be seen as a complement to the CPWF Information and Communication Strategy and a range of other guidelines that have been developed including: • Internal knowledge-­‐sharing guidelines; • Identity guidelines (to be developed); and • Working Paper series, notes for contributors. The guidelines are intended for CPWF partners working in projects or in the Topic Working Groups. These policies and guidelines should be seen as a work in progress and will be updated as and when necessar

Targeting melanoma with immunoliposomes coupled to anti-MAGEAI TCR-like single-chain antibody

Therapy of melanoma using T-cells with genetically introduced T-cell receptors (TCRs) directed against a tumor-selective cancer testis antigen (CTA) NY-ESO1 demonstrated clear antitumor responses in patients without side effects. Here, we exploited the concept of TCR-mediated targeting through introduction of single-chain variable fragment (scFv) antibodies that mimic TCRs in binding major histocompatibility complex-restricted CTA. We produced scFv antibodies directed against Melanoma AntiGEn A1 (MAGE A1) presented by human leukocyte antigen A1 (HLA-A1), in short M1/A1, and coupled these TCR-like antibodies to liposomes to achieve specific melanoma targeting. Two anti-M1/A1 antibodies with different ligand-binding affinities were derived from a phage-display library and reformatted into scFvs with an added cysteine at their carboxyl termini. Protein production conditions, ie, bacterial strain, temperature, time, and compartments, were optimized, and following production, scFv proteins were purified by immobilized metal ion affinity chromatography. Batches of pure scFvs were validated for specific binding to M1/A1-positive B-cells by flow cytometry. Coupling of scFvs to liposomes was conducted by employing different conditions, and an optimized procedure was achieved. In vitro experiments with immunoliposomes demonstrated binding of M1/A1-positive B-cells as well as M1/A1-positive melanoma cells and internalization by these cells using flow cyt

White Paper: Shifting the goal post - from high impact journals to high impact data

The purpose of this white paper is to provide an overview of the ongoing initiatives at center level to respond to changing public expectations and to the challenge of improving the conduct of science by making research data widely available. We also attempt to provide a framework for implementing open access for research data to maximize CGIAR’s impact on development. The remainder of this paper proceeds as follows; firstly a summary of the diversity of research data produced by the centers is given, followed by an overview of the existing infrastructure for data management for each Center. Secondly, some of the limitations and barriers faced by the centers in their process to mainstream research data publishing are addressed. The paper concludes with recommendations for how these limitations and barriers can be tackled

Effects of Impurity Content on the Sintering Characteristics of Plasma-Sprayed Zirconia

Yttria-stabilized zirconia powders, containing different levels of SiO2 and Al2O3, have been plasma sprayed onto metallic substrates. The coatings were detached from their substrates and a dilatometer was used to monitor the dimensional changes they exhibited during prolonged heat treatments. It was found that specimens containing higher levels of silica and alumina exhibited higher rates of linear contraction, in both in-plane and through-thickness directions. The in-plane stiffness and the through-thickness thermal conductivity were also measured after different heat treatments and these were found to increase at a greater rate for specimens with higher impurity (silica and alumina) levels. Changes in the pore architecture during heat treatments were studied using Mercury Intrusion Porosimetry (MIP). Fine scale porosity (<_50 nm) was found to be sharply reduced even by relatively short heat treatments. This is correlated with improvements in inter-splat bonding and partial healing of intra-splat microcracks, which are responsible for the observed changes in stiffness and conductivity, as well as the dimensional changes

Effectiveness of single dose rifampicin in preventing leprosy in close contacts of patients with newly diagnosed leprosy

Objective To determine the effectiveness of chemoprophylaxis using a single dose of rifampicin to prevent leprosy in close contacts. Design Single centre, double blind, cluster randomised, placebo controlled trial. SettingLeprosy control programme in two districts of northwest Bangladesh with a population of more than four million. Participants28 092 close contacts of 1037 patients with newly diagnosed leprosy. 21 711 contacts fulfilled the study requirements. Interventions A single dose of rifampicin or placebo given to close contacts in the second month of starting the index patient’s treatment, with follow-up for four years. Main outcome measure Development of clinical leprosy. Results 18 869 of the 21 711 contacts (86.9%) were followed-up at four years. Ninety one of 9452 contacts in the placebo group and 59 of 9417 in the rifampicin group had developed leprosy. The overall reduction in incidence of leprosy using a single dose of rifampicin in the first two years was 57% (95% confidence interval 33% to 72%). The groups did not differ between two and four years. The overall number needed to treat (NNT) to prevent a single case of leprosy among contacts was 297 (95% confidence interval 176 to 537). Differences were found between subgroups at two years, both in reduction of incidence and in NNT. ConclusionA single dose of rifampicin given to contacts of patients with newly diagnosed leprosy is effective at preventing the development of clinical leprosy at two years. The effect was maintained, but no difference was seen between the placebo and rifampicin groups beyond two years. Trial registration Current Controlled Trials ISRCTN61223447